{"id":"https://openalex.org/W1983452048","doi":"https://doi.org/10.1002/lary.5540940111","title":"ANTIMICROBIAL PROPHYLAXIS FOR CONTAMINATED HEAD AND NECK SURGERY","display_name":"ANTIMICROBIAL PROPHYLAXIS FOR CONTAMINATED HEAD AND NECK SURGERY","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W1983452048","doi":"https://doi.org/10.1002/lary.5540940111","mag":"1983452048","pmid":"https://pubmed.ncbi.nlm.nih.gov/6361430"},"language":"en","primary_location":{"id":"doi:10.1002/lary.5540940111","doi":"https://doi.org/10.1002/lary.5540940111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.5540940111","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002839107","display_name":"Jonas Talmadge Johnson","orcid":"https://orcid.org/0000-0002-2376-4594","observed_orcids":["https://orcid.org/0000-0002-2376-4594"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonas T. Johnson","raw_affiliation_strings":["Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108209817","display_name":"Eugene N. Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene N. Myers","raw_affiliation_strings":["Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112279010","display_name":"Barbara A. Sigler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara A. Sigler","raw_affiliation_strings":["Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039095128","display_name":"P. B. Thearle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia B. Thearle","raw_affiliation_strings":["Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh, PA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109944826","display_name":"Victor L. Schramm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor L. Schramm","raw_affiliation_strings":["Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh, PA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002839107"],"corresponding_institution_ids":[],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":12.1624,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.98833573,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"94","issue":"1","first_page":"46","last_page":"46???50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-prophylaxis","display_name":"antibiotic prophylaxis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/head-and-neck-surgery","display_name":"head and neck surgery","score":0.9549999833106995},{"id":"https://openalex.org/keywords/wound-contamination","display_name":"wound contamination","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cefazolin","display_name":"cefazolin","score":0.921999990940094},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/clindamycin","display_name":"clindamycin","score":1.0},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.9520000219345093},{"id":"https://openalex.org/keywords/laryngectomy","display_name":"laryngectomy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5870000123977661},{"id":"https://openalex.org/keywords/tracheotomy","display_name":"tracheotomy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cancer-surgery","display_name":"cancer surgery","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9395496249198914},{"id":"https://openalex.org/C2778353156","wikidata":"https://www.wikidata.org/wiki/Q415739","display_name":"Cefazolin","level":3,"score":0.8824321627616882},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6825255751609802},{"id":"https://openalex.org/C2778602436","wikidata":"https://www.wikidata.org/wiki/Q4774943","display_name":"Antibiotic prophylaxis","level":3,"score":0.6309611797332764},{"id":"https://openalex.org/C2777458120","wikidata":"https://www.wikidata.org/wiki/Q422273","display_name":"Clindamycin","level":3,"score":0.6016881465911865},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5902093648910522},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.5855955481529236},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5158223509788513},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47993403673171997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002437","descriptor_name":"Cefazolin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002981","descriptor_name":"Clindamycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011292","descriptor_name":"Premedication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013524","descriptor_name":"Surgical Flaps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013530","descriptor_name":"Surgical Wound Infection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014140","descriptor_name":"Tracheotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037981","descriptor_name":"Neck Dissection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/lary.5540940111","doi":"https://doi.org/10.1002/lary.5540940111","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.5540940111","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},{"id":"doi:10.1288/00005537-198401000-00010","doi":"https://doi.org/10.1288/00005537-198401000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1288/00005537-198401000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},{"id":"pmid:6361430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6361430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W131420864","https://openalex.org/W1985495546","https://openalex.org/W1987114356","https://openalex.org/W2036925308","https://openalex.org/W2056684015","https://openalex.org/W2088913007","https://openalex.org/W2146340881","https://openalex.org/W2268919569","https://openalex.org/W2328532586","https://openalex.org/W2329315288","https://openalex.org/W2334676005","https://openalex.org/W2339184230","https://openalex.org/W2408040893","https://openalex.org/W2410365421"],"related_works":["https://openalex.org/W2089131784","https://openalex.org/W2400190016","https://openalex.org/W1994410626","https://openalex.org/W2094681943","https://openalex.org/W2039149191","https://openalex.org/W1026877156","https://openalex.org/W2044101459","https://openalex.org/W2036213089","https://openalex.org/W2409613606","https://openalex.org/W1580538919"],"abstract_inverted_index":{"The":[0,335],"use":[1,59],"of":[2,56,64,96,137,144,159,244,278,302,323,338,351],"antibiotic":[3,34,53],"prophylaxis":[4,35],"in":[5,41,78,103,242,275,355],"head":[6,114],"and":[7,33,98,115,141,183,195,209,227,262],"neck":[8,116,317],"surgery":[9,17,117,226,288],"is":[10,29,36,40,46],"controversial.":[11],"Most":[12],"surgeons":[13],"agree":[14],"that":[15,285],"when":[16],"requires":[18],"entry":[19,119,132],"into":[20,108,120],"the":[21,25,27,62,109,121,126,135,142,217,276,349],"aerodigestive":[22,123],"tract":[23,124],"through":[24,125],"skin":[26],"wound":[28,239,280,305,352],"by":[30,234],"definition":[31],"contaminated":[32,43],"indicated":[37],"as":[38,50],"it":[39],"other":[42],"wounds.":[44],"There":[45],"no":[47,345],"general":[48],"agreement":[49],"to":[51,58,71,76,88,134,157,171,178,190,199,216],"which":[52],"or":[54,60,93,148,315,340],"combination":[55,95],"antibiotics":[57],"what":[61],"schedule":[63],"dosage":[65],"administration":[66],"should":[67],"be.":[68],"In":[69,259],"order":[70],"obtain":[72],"a":[73,81,94,145,231,267,292,297],"meaningful":[74],"data":[75],"help":[77],"decision":[79],"making,":[80],"double":[82],"blind,":[83],"randomized":[84],"study":[85,110],"was":[86,100,266],"performed":[87],"investigate":[89],"whether":[90],"cefazolin":[91],"alone":[92],"gentamicin":[97],"clindamycin":[99,184,196],"more":[101],"effective":[102],"prophylaxis.":[104],"All":[105,220],"patients":[106,153,286,327],"entered":[107],"underwent":[111],"major":[112],"oncologic":[113],"requiring":[118],"upper":[122],"skin.":[127],"Patients":[128,311],"were":[129,154,202,222,228,319],"stratified":[130],"at":[131,320],"according":[133,215],"stage":[136],"disease,":[138],"surgical":[139],"procedure,":[140],"existence":[143,337],"prior":[146,149,341],"tracheotomy":[147,339],"radiation":[150,342],"therapy.":[151],"Subsequently,":[152],"randomly":[155],"assigned":[156,218],"1":[158,166,177,185,198],"4":[160],"treatment":[161],"groups.":[162],"Group":[163,173,180,192,247,250,253,256,260,263],"I:":[164],"Cefazolin":[165,175],"day,":[167,186],"placebo":[168,187],"day":[169],"2":[170,189],"5.":[172,191,200],"II:":[174],"days":[176,188,197],"5,":[179],"III:":[181],"Gentamicin":[182,194],"IV:":[193],"Drugs":[201],"given":[203],"intravenously":[204],"beginning":[205],"3":[206,235],"hours":[207],"preoperatively":[208],"continued":[210],"postoperatively":[211,354],"every":[212],"8":[213],"hours,":[214],"schedule.":[219],"wounds":[221],"observed":[223],"daily":[224],"following":[225],"graded":[229],"on":[230,348],"predetermined":[232],"scale":[233],"unbiased":[236],"observers.":[237],"Significantly":[238],"infections":[240],"occurred":[241],"15%":[243],"all":[245],"patients.":[246],"I,":[248],"33%;":[249],"II,":[251],"20%;":[252],"III,":[254],"7%;":[255],"IV,":[257],"4%.":[258],"III":[261],"IV":[264],"there":[265],"statistically":[268,298],"significant":[269,299],"(P":[270,307,331],"less":[271,308,321,332],"than":[272,309,333],".05)":[273],"reduction":[274],"rate":[277],"postoperative":[279,304,324],"infection.":[281],"Multifactorial":[282],"analysis":[283],"demonstrated":[284],"whose":[287],"included":[289],"repair":[290],"with":[291,314],"regional":[293],"pectoral":[294],"flap":[295],"had":[296,344],"increased":[300],"chance":[301],"developing":[303],"infection":[306,325,353],".05).":[310,334],"undergoing":[312,328],"laryngectomy,":[313],"without":[316],"dissection,":[318],"risk":[322],"tham":[326],"oropharyngeal":[329],"resection":[330],"preoperative":[336],"therapy":[343],"demonstrable":[346],"effect":[347],"incidence":[350],"this":[356],"study.":[357]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}