{"id":"https://openalex.org/W1983407126","doi":"https://doi.org/10.1016/0028-3908(94)90153-8","title":"Rapid desensitization determines the pharmacology of glutamate neurotoxicity","display_name":"Rapid desensitization determines the pharmacology of glutamate neurotoxicity","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W1983407126","doi":"https://doi.org/10.1016/0028-3908(94)90153-8","mag":"1983407126","pmid":"https://pubmed.ncbi.nlm.nih.gov/7845551"},"language":"en","primary_location":{"id":"doi:10.1016/0028-3908(94)90153-8","doi":"https://doi.org/10.1016/0028-3908(94)90153-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0028-3908(94)90153-8","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035366534","display_name":"Anna M. Moudy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324021844","display_name":"St. Louis Children's Hospital","ror":"https://ror.org/00qw1qw03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324021844","https://openalex.org/I1328499231"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A MOUDY","raw_affiliation_strings":["Department of Neurology, Washington University School of Medicine, St Louis, MO","Departments of Neurology and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO 63110, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University School of Medicine, St Louis, MO","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Departments of Neurology and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO 63110, U.S.A","institution_ids":["https://openalex.org/I1324021844","https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111453720","display_name":"K A Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324021844","display_name":"St. Louis Children's Hospital","ror":"https://ror.org/00qw1qw03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324021844","https://openalex.org/I1328499231"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K YAMADA","raw_affiliation_strings":["Departments of Neurology and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO 63110, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO 63110, U.S.A","institution_ids":["https://openalex.org/I1324021844","https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028642431","display_name":"Shlomo Rothman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324021844","display_name":"St. Louis Children's Hospital","ror":"https://ror.org/00qw1qw03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324021844","https://openalex.org/I1328499231"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S ROTHMAN","raw_affiliation_strings":["Departments of Neurology and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO 63110, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO 63110, U.S.A","institution_ids":["https://openalex.org/I1324021844","https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":3.2231,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.93414815,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"8","first_page":"953","last_page":"962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rapid-desensitization","display_name":"rapid desensitization","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/non-nmda-receptors","display_name":"non-NMDA receptors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cnqx","display_name":"CNQX","score":0.824999988079071},{"id":"https://openalex.org/keywords/diazoxide","display_name":"diazoxide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cyclothiazide","display_name":"cyclothiazide","score":0.996999979019165},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.925000011920929},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.7979999780654907},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8636758327484131},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.722618818283081},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.658119261264801},{"id":"https://openalex.org/C2779803574","wikidata":"https://www.wikidata.org/wiki/Q4386534","display_name":"CNQX","level":5,"score":0.645480751991272},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6292098760604858},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6124368906021118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5928608775138855},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.5791975259780884},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43779486417770386},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.41213569045066833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33915847539901733},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.3030525743961334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23905950784683228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16516104340553284},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.09302148222923279},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001581","descriptor_name":"Benzothiadiazines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D016257","descriptor_name":"Fura-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018750","descriptor_name":"6-Cyano-7-nitroquinoxaline-2,3-dione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049993","descriptor_name":"Sodium Chloride Symporter Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0028-3908(94)90153-8","doi":"https://doi.org/10.1016/0028-3908(94)90153-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0028-3908(94)90153-8","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:7845551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7845551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4073722947","display_name":null,"funder_award_id":"K08 01443","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G765946927","display_name":null,"funder_award_id":"R01 19988","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W21559756","https://openalex.org/W1480873606","https://openalex.org/W1564080580","https://openalex.org/W1588361932","https://openalex.org/W1617042306","https://openalex.org/W1636225847","https://openalex.org/W1639407471","https://openalex.org/W1774281578","https://openalex.org/W1842711843","https://openalex.org/W1890775238","https://openalex.org/W1896045165","https://openalex.org/W1920015810","https://openalex.org/W1979668799","https://openalex.org/W1984628432","https://openalex.org/W2002360249","https://openalex.org/W2009667219","https://openalex.org/W2012762150","https://openalex.org/W2016759315","https://openalex.org/W2028536221","https://openalex.org/W2028700420","https://openalex.org/W2037772094","https://openalex.org/W2042826370","https://openalex.org/W2048011585","https://openalex.org/W2063261415","https://openalex.org/W2063685774","https://openalex.org/W2063792561","https://openalex.org/W2066168019","https://openalex.org/W2068649586","https://openalex.org/W2093325915","https://openalex.org/W2094557223","https://openalex.org/W2094890765","https://openalex.org/W2095358033","https://openalex.org/W2128904157","https://openalex.org/W2135389271","https://openalex.org/W2139748951","https://openalex.org/W2141260882","https://openalex.org/W2174668858","https://openalex.org/W2236386217","https://openalex.org/W2400840652"],"related_works":["https://openalex.org/W2139748951","https://openalex.org/W2094890765","https://openalex.org/W2008706843","https://openalex.org/W2089892818","https://openalex.org/W31441367","https://openalex.org/W1989202699","https://openalex.org/W1998670757","https://openalex.org/W1850793716","https://openalex.org/W1978507389","https://openalex.org/W2048435545"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}