{"id":"https://openalex.org/W1983348978","doi":"https://doi.org/10.1097/00007890-198610000-00011","title":"IMMUNOLOGICAL CHARACTERISTICS OF PURIFIED PANCREATIC ISLET GRAFTS","display_name":"IMMUNOLOGICAL CHARACTERISTICS OF PURIFIED PANCREATIC ISLET GRAFTS","publication_year":1986,"publication_date":"1986-10-01","ids":{"openalex":"https://openalex.org/W1983348978","doi":"https://doi.org/10.1097/00007890-198610000-00011","mag":"1983348978","pmid":"https://pubmed.ncbi.nlm.nih.gov/3094210"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-198610000-00011","doi":"https://doi.org/10.1097/00007890-198610000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-198610000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101841964","display_name":"Mitsukazu Gotoh","orcid":"https://orcid.org/0000-0001-9147-5711","observed_orcids":["https://orcid.org/0000-0001-9147-5711"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitsukazu Gotoh","raw_affiliation_strings":["The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047141592","display_name":"Takashi Maki","orcid":"https://orcid.org/0000-0002-2143-3783","observed_orcids":["https://orcid.org/0000-0002-2143-3783"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Maki","raw_affiliation_strings":["The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109288344","display_name":"Susumu Satomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susumu Satomi","raw_affiliation_strings":["The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","Leadership"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Leadership","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112192875","display_name":"J Porter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janis Porter","raw_affiliation_strings":["The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038938677","display_name":"Anthony P. Monaco","orcid":"https://orcid.org/0000-0001-7480-3197","observed_orcids":["https://orcid.org/0000-0001-7480-3197"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony P. Monaco","raw_affiliation_strings":["The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Departments of Surgery and Pathology, Harvard Medical School at the Cancer Research Institute, New England Deaconess Hospital Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":1.7891,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.82901921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"42","issue":"4","first_page":"387","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-islet-allograft","display_name":"pancreatic islet allograft","score":0.9150000214576721},{"id":"https://openalex.org/keywords/islet-purification","display_name":"islet purification","score":0.8140000104904175},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7609999775886536},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/islet-graft-survival","display_name":"islet graft survival","score":0.6150000095367432},{"id":"https://openalex.org/keywords/donor-spleen-cells","display_name":"donor spleen cells","score":0.6830000281333923},{"id":"https://openalex.org/keywords/collagenase-digestion","display_name":"collagenase digestion","score":0.699999988079071},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/h-2-compatibility","display_name":"H-2 compatibility","score":0.6349999904632568},{"id":"https://openalex.org/keywords/renal-subcapsular-transplantation","display_name":"renal subcapsular transplantation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/immunostimulation","display_name":"immunostimulation","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7458952069282532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4830777943134308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30702316761016846},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28030478954315186},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.19072207808494568}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-198610000-00011","doi":"https://doi.org/10.1097/00007890-198610000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-198610000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:3094210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3094210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6725584388","display_name":"SUPPRESSOR LYMPHOKINE INVOLVED IN GRAFT UNRESPONSIVENESS","funder_award_id":"R01AI020686","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7001082392","display_name":null,"funder_award_id":"AI 14551-09","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967588804","https://openalex.org/W2162176303","https://openalex.org/W2021961375","https://openalex.org/W2036477457","https://openalex.org/W2527861383","https://openalex.org/W808845302","https://openalex.org/W2128804840","https://openalex.org/W1517171082","https://openalex.org/W1985324706","https://openalex.org/W2027718089"],"abstract_inverted_index":{"In":[0,87,147],"a":[1,77,111,191],"DBA/2":[2],"(H-2d)":[3],"pancreatic":[4],"islet-to-B6AF1":[5],"(H-2b/k.d)":[6],"recipient":[7],"combination,":[8],"the":[9,50,63,92,133,149,153,161,185],"graft":[10,113],"survival":[11,79,114],"of":[12,19,54,82,91,103,116,135,152,163,196,204],"hand-picked":[13],"islets":[14,22,105],"was":[15,60,157],"compared":[16],"with":[17,37,76,160],"that":[18,23,171],"\"crude":[20],"digested\"":[21],"were":[24,35,47,68,129,141],"prepared":[25],"simply":[26],"by":[27],"collagenase":[28],"digestion":[29],"and":[30,34,40,42,74,106,180],"Ficoll":[31],"gradient":[32],"separation":[33],"contaminated":[36],"lymph":[38,176],"nodes":[39],"vascular":[41,178],"ductal":[43,181],"tissue.":[44],"Islet":[45],"allografts":[46,67,95,156,189],"transplanted":[48],"into":[49],"renal":[51],"subcapsular":[52],"space":[53],"streptozotocin-induced":[55],"diabetic":[56],"recipients.":[57],"No":[58],"immunosuppression":[59],"used.":[61],"All":[62],"crude":[64,186],"digested":[65,187],"islet":[66,94,139,155,188,205],"acutely":[69,142],"rejected":[70,143],"between":[71],"days":[72],"7":[73],"18":[75],"median":[78],"time":[80,134,151],"(MST)":[81],"10.2":[83],"+/-":[84,118],"2.5":[85],"days.":[86,100,146],"contrast,":[88],"33%":[89],"(3/9)":[90],"purified":[93,104,138,154],"survived":[96],"more":[97],"than":[98],"100":[99],"Simultaneous":[101],"transplantation":[102],"contaminating":[107,172],"tissue":[108],"resulted":[109],"in":[110,184,201],"shorter":[112],"(MST":[115],"15.6":[117],"3.7":[119],"days).":[120],"When":[121],"5":[122],"X":[123],"10(7)":[124],"donor":[125,164],"strain":[126],"spleen":[127,165],"cells":[128,166],"injected":[130],"i.v.":[131],"at":[132],"transplantation,":[136],"all":[137],"grafts":[140],"within":[144],"9":[145],"addition,":[148],"rejection":[150,203],"inversely":[158],"correlated":[159],"number":[162],"injected.":[167],"These":[168],"results":[169],"indicate":[170],"tissues":[173],"such":[174],"as":[175],"nodes,":[177],"tissue,":[179],"fragments":[182],"present":[183],"are":[190],"major":[192],"stimulus":[193],"for":[194],"induction":[195],"an":[197],"immune":[198],"response":[199],"resulting":[200],"acute":[202],"allografts.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}