{"id":"https://openalex.org/W1983333243","doi":"https://doi.org/10.1111/j.1460-9568.2005.03977.x","title":"The novel cytosolic RING finger protein dactylidin is up\u2010regulated in brains of patients with Alzheimer's disease","display_name":"The novel cytosolic RING finger protein dactylidin is up\u2010regulated in brains of patients with Alzheimer's disease","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W1983333243","doi":"https://doi.org/10.1111/j.1460-9568.2005.03977.x","mag":"1983333243","pmid":"https://pubmed.ncbi.nlm.nih.gov/15813938"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.2005.03977.x","doi":"https://doi.org/10.1111/j.1460-9568.2005.03977.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2005.03977.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036499913","display_name":"Ruth C. von Rotz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ruth C. Von Rotz","raw_affiliation_strings":["Division of Psychiatry Research, University of Zurich, Switzerland. s.kins@zmbh.uni-heidelberg.de","Division of Psychiatry Research University of Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry Research, University of Zurich, Switzerland. s.kins@zmbh.uni-heidelberg.de","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Division of Psychiatry Research University of Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047845189","display_name":"Stefan Kins","orcid":"https://orcid.org/0000-0002-7231-4872","observed_orcids":["https://orcid.org/0000-0002-7231-4872"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Kins","raw_affiliation_strings":["Center of Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, D\u201069120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Biology (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, D\u201069120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076343799","display_name":"Rainer Hipfel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Hipfel","raw_affiliation_strings":["Evotec NeuroSciences GmbH, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec NeuroSciences GmbH, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113582408","display_name":"Heinz von der Kammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz Von Der Kammer","raw_affiliation_strings":["Evotec NeuroSciences GmbH, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec NeuroSciences GmbH, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109156775","display_name":"Roger M. Nitsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger M. Nitsch","raw_affiliation_strings":["Division of Psychiatry Research University of Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry Research University of Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":0.725,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.61240578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"5","first_page":"1289","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ring-finger-protein","display_name":"RING finger protein","score":0.7749999761581421},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7960000038146973},{"id":"https://openalex.org/keywords/selective-neuronal-vulnerability","display_name":"selective neuronal vulnerability","score":0.7260000109672546},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.7139999866485596},{"id":"https://openalex.org/keywords/inferior-temporal-cortex","display_name":"inferior temporal cortex","score":0.9900000095367432},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6430000066757202},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8209999799728394},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9419999718666077},{"id":"https://openalex.org/keywords/gene-upregulation","display_name":"gene upregulation","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.734659731388092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7017068862915039},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.6302803158760071},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5392528772354126},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40236896276474},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3888595998287201},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36519113183021545},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3086909055709839},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2559610605239868},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23555752635002136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18888279795646667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17724651098251343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10788601636886597}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1460-9568.2005.03977.x","doi":"https://doi.org/10.1111/j.1460-9568.2005.03977.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2005.03977.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:15813938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15813938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Comparative Study"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/62114","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/62114","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"von Rotz, R. C., Kins, S., Hipfel, R., von der Kammer, H., & Nitsch, R. M. (2005). The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer\u2019s disease. European Journal of Neuroscience, 21, 1289\u20131298. https://doi.org/10.1111/j.1460-9568.2005.03977.x","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:49372","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/49372","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"von Rotz, R C; Kins, S; Hipfel, R; von der Kammer, H; Nitsch, R M (2005). The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. European Journal of Neuroscience, 21(5):1289-1298.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W74077904","https://openalex.org/W1480987708","https://openalex.org/W1482580692","https://openalex.org/W1525734429","https://openalex.org/W1550876205","https://openalex.org/W1588279803","https://openalex.org/W1832030339","https://openalex.org/W1917787745","https://openalex.org/W1971389338","https://openalex.org/W1972939055","https://openalex.org/W1986188355","https://openalex.org/W1997369314","https://openalex.org/W2004620083","https://openalex.org/W2022376508","https://openalex.org/W2023578962","https://openalex.org/W2027533965","https://openalex.org/W2029923284","https://openalex.org/W2041685210","https://openalex.org/W2042716629","https://openalex.org/W2058147620","https://openalex.org/W2073936529","https://openalex.org/W2075191006","https://openalex.org/W2076606883","https://openalex.org/W2077965454","https://openalex.org/W2084453905","https://openalex.org/W2088619528","https://openalex.org/W2089865526","https://openalex.org/W2091673419","https://openalex.org/W2095750495","https://openalex.org/W2100120613","https://openalex.org/W2111417422","https://openalex.org/W2128408334","https://openalex.org/W2138878035","https://openalex.org/W2143528416","https://openalex.org/W2159838014","https://openalex.org/W2166987747","https://openalex.org/W2240030476","https://openalex.org/W2412700355","https://openalex.org/W4252368281"],"related_works":["https://openalex.org/W2041140379","https://openalex.org/W2020430435","https://openalex.org/W2066451962","https://openalex.org/W2096770796","https://openalex.org/W2034947823","https://openalex.org/W2036814685","https://openalex.org/W2145707863","https://openalex.org/W2097632269","https://openalex.org/W1975907995","https://openalex.org/W3120777691"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,77,121,170],"characterized":[4],"by":[5,187],"a":[6,28,102,108,146,188],"progressive":[7],"degeneration":[8],"of":[9,14,20,31,37,55,67,71,86,132,149,168,175,182,201],"neurons":[10],"along":[11],"with":[12,47],"deposition":[13],"amyloid":[15],"plaques":[16],"and":[17,34,81,128,151],"the":[18,72,84,173,199],"formation":[19],"neurofibrillary":[21],"tangles.":[22],"Neurodegeneration":[23],"in":[24,64,83,124,129,139,177,198],"AD":[25,183],"follows":[26],"both":[27,79],"spatial":[29],"pattern":[30],"selective":[32,49],"vulnerability":[33],"temporal":[35,74],"staging":[36],"affected":[38,78],"neurons.":[39,140],"In":[40],"order":[41],"to":[42,92],"address":[43],"transcriptional":[44],"changes":[45],"associated":[46],"this":[48],"vulnerability,":[50],"we":[51,89],"used":[52],"subtractive":[53],"hybridization":[54,131],"transcripts":[56,70],"derived":[57],"from":[58,96],"human":[59],"frontal":[60],"cortex,":[61,75],"which":[62,76],"degenerates":[63],"late":[65],"stages":[66],"AD,":[68],"against":[69],"inferior":[73],"heavily":[80],"early":[82,197],"course":[85],"AD.":[87],"Moreover,":[88],"compared":[90],"these":[91],"brain":[93,134,180],"sections":[94,135],"obtained":[95],"age-matched":[97],"control":[98],"subjects.":[99],"We":[100],"isolated":[101],"differentially":[103],"expressed":[104,123],"novel":[105],"gene":[106],"encoding":[107],"polypeptide":[109],"that":[110,193],"contained":[111],"an":[112,164],"amino-terminal":[113],"C3HC4":[114],"RING":[115,156],"finger":[116,157],"domain,":[117],"called":[118],"dactylidin.":[119],"It":[120],"ubiquitously":[122],"all":[125,153],"tissues":[126,181],"examined":[127],"situ":[130],"mouse":[133],"revealed":[136,145],"specific":[137],"expression":[138,143],"Further,":[141],"heterologous":[142],"studies":[144],"cytoplasmic":[147,155],"localization":[148],"dactylidin":[150,169,176,194],"as":[152,160],"known":[154],"proteins":[158],"function":[159,167,196],"ubiquitin":[161],"protein":[162],"ligases,":[163],"E3-like":[165],"ligase":[166],"probable.":[171],"However,":[172],"up-regulation":[174],"highly":[178],"vulnerable":[179],"patients":[184],"was":[185],"confirmed":[186],"quantitative":[189],"PCR":[190],"approach,":[191],"suggesting":[192],"may":[195],"progression":[200],"neurodegenerative":[202],"diseases.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}