{"id":"https://openalex.org/W1983328443","doi":"https://doi.org/10.1016/s0014-2999(00)00235-1","title":"Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine","display_name":"Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W1983328443","doi":"https://doi.org/10.1016/s0014-2999(00)00235-1","mag":"1983328443","pmid":"https://pubmed.ncbi.nlm.nih.gov/10856442"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(00)00235-1","doi":"https://doi.org/10.1016/s0014-2999(00)00235-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(00)00235-1","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102781597","display_name":"Masatake Fujimura","orcid":"https://orcid.org/0000-0001-5532-3577","observed_orcids":["https://orcid.org/0000-0001-5532-3577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masatake Fujimura","raw_affiliation_strings":["Tokyo Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd, Saitama, Iruma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd, Saitama, Iruma, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032453300","display_name":"Kenji Hashimoto","orcid":"https://orcid.org/0000-0002-8892-0439","observed_orcids":["https://orcid.org/0000-0002-8892-0439"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kenji Hashimoto","raw_affiliation_strings":["Tokyo Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd, Iruma, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd, Iruma, Saitama, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040311211","display_name":"Keiji Yamagami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiji Yamagami","raw_affiliation_strings":["Tokyo Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd, Iruma, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Laboratories, Pharmaceutical Research Division, Yoshitomi Pharmaceutical Industries, Ltd, Iruma, Saitama, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032453300"],"corresponding_institution_ids":[],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":1.6808,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82902681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"398","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.9779999852180481},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.8140000104904175},{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":1.0},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":1.0},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/c-fos-mrna","display_name":"c-fos mRNA","score":0.9789999723434448},{"id":"https://openalex.org/keywords/retrosplenial-cortex","display_name":"retrosplenial cortex","score":0.9909999966621399},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.5590000152587891},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2777836312","wikidata":"https://www.wikidata.org/wiki/Q4386371","display_name":"Dizocilpine","level":4,"score":0.8769533634185791},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.7333205938339233},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.6975328922271729},{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.68984454870224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6744453310966492},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.5108417868614197},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5022265911102295},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.4566667377948761},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.45047861337661743},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.44549325108528137},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.42814069986343384},{"id":"https://openalex.org/C2780200011","wikidata":"https://www.wikidata.org/wiki/Q7317081","display_name":"Retrosplenial cortex","level":3,"score":0.4174901843070984},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3689610958099365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3177946209907532},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3101166784763336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28471776843070984},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2584943473339081},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.23598402738571167},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.18416407704353333},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.17288702726364136},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.16463395953178406},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12534919381141663},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07300963997840881}],"mesh":[{"descriptor_ui":"D000077152","descriptor_name":"Olanzapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(00)00235-1","doi":"https://doi.org/10.1016/s0014-2999(00)00235-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(00)00235-1","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:10856442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10856442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332178","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W51778931","https://openalex.org/W249845531","https://openalex.org/W595934729","https://openalex.org/W1722979865","https://openalex.org/W1797972710","https://openalex.org/W1847132166","https://openalex.org/W1938004598","https://openalex.org/W1954888178","https://openalex.org/W1958815412","https://openalex.org/W1972253384","https://openalex.org/W1974696185","https://openalex.org/W1975146184","https://openalex.org/W1975323099","https://openalex.org/W1981234599","https://openalex.org/W1992747195","https://openalex.org/W1994287251","https://openalex.org/W1994320523","https://openalex.org/W1996110202","https://openalex.org/W1998691777","https://openalex.org/W2006369614","https://openalex.org/W2020995685","https://openalex.org/W2023321720","https://openalex.org/W2026621438","https://openalex.org/W2028884770","https://openalex.org/W2034444431","https://openalex.org/W2040936201","https://openalex.org/W2041483782","https://openalex.org/W2049527932","https://openalex.org/W2057145321","https://openalex.org/W2058601367","https://openalex.org/W2059807892","https://openalex.org/W2064939199","https://openalex.org/W2069656785","https://openalex.org/W2070241900","https://openalex.org/W2070960646","https://openalex.org/W2081662762","https://openalex.org/W2084223366","https://openalex.org/W2090891380","https://openalex.org/W2093248761","https://openalex.org/W2138368199","https://openalex.org/W2150117416","https://openalex.org/W2158137297","https://openalex.org/W2163589408","https://openalex.org/W2163815564","https://openalex.org/W2164674870","https://openalex.org/W2323525879","https://openalex.org/W2477416481","https://openalex.org/W6641067975"],"related_works":["https://openalex.org/W1972249792","https://openalex.org/W1964920667","https://openalex.org/W2062610641","https://openalex.org/W2085147949","https://openalex.org/W2145455946","https://openalex.org/W6963721162","https://openalex.org/W2084596811","https://openalex.org/W184831226","https://openalex.org/W2001083430","https://openalex.org/W2058155339"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}