{"id":"https://openalex.org/W1983308408","doi":"https://doi.org/10.1042/bj20071033","title":"Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding","display_name":"Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding","publication_year":2008,"publication_date":"2008-01-29","ids":{"openalex":"https://openalex.org/W1983308408","doi":"https://doi.org/10.1042/bj20071033","mag":"1983308408","pmid":"https://pubmed.ncbi.nlm.nih.gov/17973628"},"language":"en","primary_location":{"id":"doi:10.1042/bj20071033","doi":"https://doi.org/10.1042/bj20071033","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20071033","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049948464","display_name":"Ingeborg Winge","orcid":"https://orcid.org/0000-0001-6139-5999","observed_orcids":["https://orcid.org/0000-0001-6139-5999"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Ingeborg Winge","raw_affiliation_strings":["Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078310916","display_name":"Jeffrey A. McKinney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jeffrey\u00a0A. Mckinney","raw_affiliation_strings":["Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101964050","display_name":"Ming Ying","orcid":"https://orcid.org/0000-0003-2653-4273","observed_orcids":["https://orcid.org/0000-0003-2653-4273"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Ming Ying","raw_affiliation_strings":["Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089597821","display_name":"Clive S. D\u2019Santos","orcid":"https://orcid.org/0000-0003-4592-0487","observed_orcids":["https://orcid.org/0000-0003-4592-0487","https://orcid.org/0000-0003-3425-7288"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Clive\u00a0S. D'Santos","raw_affiliation_strings":["PROBE Proteomic Unit, Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PROBE Proteomic Unit, Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081698578","display_name":"Rune Kleppe","orcid":"https://orcid.org/0000-0002-6086-755X","observed_orcids":["https://orcid.org/0000-0002-6086-755X"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Rune Kleppe","raw_affiliation_strings":["Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114004657","display_name":"Per Morten Knappskog","orcid":"https://orcid.org/0000-0002-8277-4530","observed_orcids":["https://orcid.org/0000-0002-8277-4530"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Per\u00a0M. Knappskog","raw_affiliation_strings":["Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway","Department of Clinical Medicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, 5021 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]},{"raw_affiliation_string":"Department of Clinical Medicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055442295","display_name":"Jan Haavik","orcid":"https://orcid.org/0000-0001-7865-2808","observed_orcids":["https://orcid.org/0000-0001-7865-2808"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Jan Haavik","raw_affiliation_strings":["Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","Department of Psychiatry, Haukeland University Hospital, 5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Jonas Liesv. 91,5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Psychiatry, Haukeland University Hospital, 5021 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049948464","https://openalex.org/A5055442295","https://openalex.org/A5081698578","https://openalex.org/A5101964050"],"corresponding_institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"],"apc_list":null,"apc_paid":null,"fwci":2.5984,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.90213567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"410","issue":"1","first_page":"195","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.2151000052690506,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.07010000199079514,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan-hydroxylase-2","display_name":"tryptophan hydroxylase 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/14-3-3-proteins","display_name":"14-3-3 proteins","score":0.9739999771118164},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8880000114440918},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/enzyme-stability","display_name":"enzyme stability","score":0.6940000057220459},{"id":"https://openalex.org/keywords/serotonin-synthesis","display_name":"serotonin synthesis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.7200000286102295},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.6700000166893005},{"id":"https://openalex.org/keywords/calcium-calmodulin-dependent-protein-kinase-ii","display_name":"calcium/calmodulin-dependent protein kinase II","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2779999352","wikidata":"https://www.wikidata.org/wiki/Q18049432","display_name":"TPH2","level":5,"score":0.9547597169876099},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7905428409576416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6377169489860535},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5836713314056396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5510910749435425},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.5424798727035522},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5075229406356812},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4873522222042084},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.47552230954170227},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4423045516014099},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.4141526520252228},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.12753868103027344},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09079799056053162},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/bj20071033","doi":"https://doi.org/10.1042/bj20071033","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20071033","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:17973628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17973628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1504478980","https://openalex.org/W1507452489","https://openalex.org/W1536745609","https://openalex.org/W1683282950","https://openalex.org/W1965726341","https://openalex.org/W1970777073","https://openalex.org/W1970952147","https://openalex.org/W1971669558","https://openalex.org/W1976114760","https://openalex.org/W1976590570","https://openalex.org/W1983848757","https://openalex.org/W1984807839","https://openalex.org/W1988107743","https://openalex.org/W1988370141","https://openalex.org/W1988758124","https://openalex.org/W1991518845","https://openalex.org/W1997040758","https://openalex.org/W1997221253","https://openalex.org/W1998035590","https://openalex.org/W1999951243","https://openalex.org/W2006067437","https://openalex.org/W2012243761","https://openalex.org/W2030822689","https://openalex.org/W2031167586","https://openalex.org/W2033497490","https://openalex.org/W2033889320","https://openalex.org/W2035663126","https://openalex.org/W2040851812","https://openalex.org/W2043299288","https://openalex.org/W2044694582","https://openalex.org/W2047082750","https://openalex.org/W2068183862","https://openalex.org/W2068624303","https://openalex.org/W2071075259","https://openalex.org/W2073558017","https://openalex.org/W2077726906","https://openalex.org/W2082020876","https://openalex.org/W2094823700","https://openalex.org/W2099255819","https://openalex.org/W2104080537","https://openalex.org/W2104244040","https://openalex.org/W2112995156","https://openalex.org/W2114431124","https://openalex.org/W2130060410","https://openalex.org/W2136387223","https://openalex.org/W2158714788","https://openalex.org/W2161084332","https://openalex.org/W2411130778"],"related_works":["https://openalex.org/W2040851812","https://openalex.org/W2026255106","https://openalex.org/W1982959965","https://openalex.org/W1984807839","https://openalex.org/W2039360378","https://openalex.org/W1988107743","https://openalex.org/W1507452489","https://openalex.org/W1970777073","https://openalex.org/W20086726","https://openalex.org/W2163512235"],"abstract_inverted_index":{"TPH":[0],"(tryptophan":[1],"hydroxylase)":[2],"catalyses":[3],"the":[4,8,24,33,135,166,184,216,229,235],"rate-limiting":[5],"step":[6],"in":[7,14,20,40,44,160,198,212,234],"synthesis":[9],"of":[10,65,68,70,82,108,134,156,218,231],"serotonin,":[11],"and":[12,23,27,43,50,105,117,132,165,169,189,201,214,222],"exists":[13],"two":[15],"isoforms:":[16],"TPH1,":[17],"mainly":[18,143],"found":[19],"peripheral":[21],"tissues":[22],"pineal":[25],"body,":[26],"TPH2,":[28,164],"a":[29,63,80,154,195,210],"neuronal":[30],"form.":[31],"In":[32],"present":[34],"study":[35],"human":[36],"TPH2":[37,58,122,181,221],"was":[38,59,125,142,151,172],"expressed":[39],"Escherichia":[41],"coli":[42],"HEK":[45],"(human":[46],"embryonic":[47],"kidney)-293":[48],"cells":[49,162],"phosphorylated":[51,61,92,97,152],"using":[52],"several":[53,109],"different":[54],"mammalian":[55],"protein":[56,87],"kinases.":[57],"rapidly":[60],"to":[62,79,145,153,158,183],"stoichiometry":[64,81,155,171],"2":[66],"mol":[67],"phosphate/mol":[69],"subunit":[71],"by":[72,84,101,127],"PKA":[73,95,130],"(protein":[74],"kinase":[75,88],"A),":[76],"but":[77,94],"only":[78],"0.2":[83],"Ca(2+)/calmodulin":[85],"dependent":[86],"II.":[89],"Both":[90],"kinases":[91],"Ser(19),":[93,114],"also":[96],"Ser(104),":[98],"as":[99],"determined":[100],"MS,":[102],"phosphospecific":[103],"antibodies":[104],"site-directed":[106],"mutagenesis":[107],"possible":[110],"phosphorylation":[111,131,146,170,219],"sites,":[112],"i.e.":[113],"Ser(99),":[115],"Ser(104)":[116],"Ser(306).":[118],"On":[119],"average,":[120],"purified":[121],"WT":[123],"(wild-type)":[124],"activated":[126],"30%":[128],"after":[129],"studies":[133],"mutant":[136],"enzymes":[137],"showed":[138],"that":[139,205,223],"enzyme":[140,167,199],"activation":[141],"due":[144],"at":[147],"Ser(19).":[148],"This":[149,203],"site":[150],"up":[157],"50%":[159],"HEK-293":[161],"expressing":[163],"activity":[168],"further":[173,196],"increased":[174],"upon":[175],"treatment":[176],"with":[177,191],"forskolin.":[178],"Purified":[179],"PKA-phosphorylated":[180],"bound":[182],"14-3-3":[185,206],"proteins":[186,207],"gamma,":[187],"epsilon":[188],"BMH1":[190],"high":[192],"affinity,":[193],"causing":[194],"increase":[197],"stability":[200],"activity.":[202],"indicates":[204],"could":[208],"play":[209],"role":[211],"consolidating":[213],"strengthening":[215],"effects":[217],"on":[220],"they":[224],"may":[225],"be":[226],"important":[227],"for":[228],"regulation":[230],"serotonin":[232],"function":[233],"nervous":[236],"system.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}