{"id":"https://openalex.org/W1983249155","doi":"https://doi.org/10.1117/12.274344","title":"Factors to be considered for robust high-throughput automated DNA sequencing using a multiple-capillary array instrument","display_name":"Factors to be considered for robust high-throughput automated DNA sequencing using a multiple-capillary array instrument","publication_year":1997,"publication_date":"1997-05-22","ids":{"openalex":"https://openalex.org/W1983249155","doi":"https://doi.org/10.1117/12.274344","mag":"1983249155"},"language":"en","primary_location":{"id":"doi:10.1117/12.274344","doi":"https://doi.org/10.1117/12.274344","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.274344","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052993181","display_name":"Emanuel Carrilho","orcid":"https://orcid.org/0000-0001-7351-8220","observed_orcids":["https://orcid.org/0000-0001-7351-8220"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emanuel Carrilho","raw_affiliation_strings":["Northeastern Univ. and Univ. of Sao Paulo (Brazil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ. and Univ. of Sao Paulo (Brazil)","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000482958","display_name":"Arthur W. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur W. Miller","raw_affiliation_strings":["Northeastern Univ. (United States)","Northeastern University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ. (United States)","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001047095","display_name":"Marie C. Ruiz\u2010Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie C. Ruiz-Martinez","raw_affiliation_strings":["Northeastern Univ. (United States)","Northeastern University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ. (United States)","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039536510","display_name":"Lev Kotler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lev Kotler","raw_affiliation_strings":["Northeastern Univ. (United States)","Northeastern University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ. (United States)","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072339639","display_name":"Jeffrey Kesilman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Kesilman","raw_affiliation_strings":["Northeastern Univ. (United States)","Northeastern University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ. (United States)","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020025505","display_name":"Barry L. Karger","orcid":"https://orcid.org/0000-0002-9786-0036","observed_orcids":["https://orcid.org/0000-0002-9786-0036","https://orcid.org/0000-0001-9899-6317"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry L. Karger","raw_affiliation_strings":["Northeastern Univ. (United States)","Northeastern University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern Univ. (United States)","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, USA","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0722,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68164794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2985","issue":null,"first_page":"4","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/automated-dna-sequencing","display_name":"automated DNA sequencing","score":0.9409999847412109},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.7950000166893005},{"id":"https://openalex.org/keywords/air-bubble-trapping","display_name":"air bubble trapping","score":0.5450000166893005},{"id":"https://openalex.org/keywords/sample-injection","display_name":"sample injection","score":0.6179999709129333},{"id":"https://openalex.org/keywords/crosstalk-reduction","display_name":"crosstalk reduction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/instrument-design","display_name":"instrument design","score":0.5410000085830688},{"id":"https://openalex.org/keywords/data-processing-software","display_name":"data processing software","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6385865807533264},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.6081541776657104},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.5924068689346313},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5860007405281067},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5648301839828491},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.4984583854675293},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49008071422576904},{"id":"https://openalex.org/C97562148","wikidata":"https://www.wikidata.org/wiki/Q5357989","display_name":"Electrode array","level":3,"score":0.45462632179260254},{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.43604737520217896},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.42948219180107117},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.42659544944763184},{"id":"https://openalex.org/C2780551164","wikidata":"https://www.wikidata.org/wiki/Q2306599","display_name":"Column (typography)","level":3,"score":0.41966792941093445},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.4188554584980011},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.41197165846824646},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3952789306640625},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3006938695907593},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28623276948928833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2477257251739502},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24028366804122925},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.16453754901885986},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09758225083351135},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.274344","doi":"https://doi.org/10.1117/12.274344","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.274344","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W119028027","https://openalex.org/W2090388952","https://openalex.org/W2439293745","https://openalex.org/W2179624807","https://openalex.org/W1984388971","https://openalex.org/W2040266948","https://openalex.org/W2092849045","https://openalex.org/W2320448700","https://openalex.org/W97005966","https://openalex.org/W2014454097"],"abstract_inverted_index":{"The":[0],"overall":[1],"goal":[2],"of":[3,77,82,117,127,153],"our":[4],"program":[5],"is":[6,111],"to":[7,33,40,113],"develop":[8],"a":[9,24,128,163],"robust,":[10],"high":[11],"throughput,":[12],"fully":[13],"automated":[14],"DNA":[15],"sequencing":[16],"instrument":[17,59,67],"based":[18,69],"on":[19,56,70,107,131],"replaceable":[20],"polymer":[21,36,92],"solutions":[22],"using":[23],"multicapillary":[25],"array.":[26],"Significant":[27],"effort":[28],"has":[29],"already":[30],"been":[31],"devoted":[32],"column":[34],"and":[35,61,80,104],"chemistry":[37],"in":[38,47,58,166],"order":[39],"obtain":[41],"long":[42],"read":[43],"lengths":[44],"per":[45],"run":[46],"fast":[48],"analysis":[49],"time.":[50],"In":[51],"this":[52,89],"paper":[53],"we":[54],"report":[55],"progress":[57],"considerations":[60],"data":[62],"processing":[63],"software.":[64],"A":[65,124],"simple":[66],"design,":[68],"no":[71],"moving":[72],"parts":[73],"for":[74,88],"continuous":[75],"illumination":[76],"the":[78,83,97,101,108,115,132,150,154],"capillaries":[79],"detection":[81],"fluorescent":[84],"light":[85],"was":[86],"used":[87],"study.":[90],"Our":[91,145],"solution":[93,122],"replacement":[94],"system":[95],"with":[96],"permanent":[98],"connection":[99],"between":[100],"buffer/chamber":[102],"manifold":[103],"capillary":[105,170],"columns":[106],"detector":[109],"side":[110,134],"designed":[112],"prevent":[114],"trapping":[116,137],"air":[118,136],"bubbles":[119],"during":[120,138],"matrix":[121],"replacement.":[123],"special":[125],"construction":[126],"column-electrode":[129],"couple":[130],"injection":[133,140],"precludes":[135],"sample":[139,143],"from":[141,157],"small":[142],"volumes.":[144],"in-house":[146],"software":[147],"now":[148],"features":[149],"significant":[151],"reduction":[152],"crosstalk":[155],"signal":[156],"neighbor":[158],"columns,":[159],"which":[160],"may":[161],"be":[162],"potential":[164],"problem":[165],"densely":[167],"packed":[168],"large":[169],"array":[171],"sequencers.":[172]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
