{"id":"https://openalex.org/W1983241965","doi":"https://doi.org/10.1007/s11060-007-9417-0","title":"Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells","display_name":"Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells","publication_year":2007,"publication_date":"2007-06-14","ids":{"openalex":"https://openalex.org/W1983241965","doi":"https://doi.org/10.1007/s11060-007-9417-0","mag":"1983241965","pmid":"https://pubmed.ncbi.nlm.nih.gov/17568996"},"language":"en","primary_location":{"id":"doi:10.1007/s11060-007-9417-0","doi":"https://doi.org/10.1007/s11060-007-9417-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11060-007-9417-0","pdf_url":null,"source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mia Carapancea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mia Carapancea","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081460197","display_name":"Daria Cosaceanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daria Cosaceanu","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079588345","display_name":"Raluca A. Budiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Raluca Budiu","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000108573","display_name":"Anna Kwieci\u0144ska","orcid":"https://orcid.org/0000-0001-7218-1566","observed_orcids":["https://orcid.org/0000-0001-7218-1566"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Kwiecinska","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030933704","display_name":"Ligia Gabriela T\u0103t\u0103ranu","orcid":"https://orcid.org/0000-0001-6788-5833","observed_orcids":["https://orcid.org/0000-0001-6788-5833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ligia Tataranu","raw_affiliation_strings":["Department of Neurosurgery, Bagdasar-Arseni Hospital, Bucharest, Romania","Bagdasar-Arseni Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Bagdasar-Arseni Hospital, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"Bagdasar-Arseni Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113465601","display_name":"Vasile Gheorghe Ciubotaru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vasile Ciubotaru","raw_affiliation_strings":["Department of Neurosurgery, Bagdasar-Arseni Hospital, Bucharest, Romania","Bagdasar-Arseni Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Bagdasar-Arseni Hospital, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"Bagdasar-Arseni Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143367","display_name":"Oana Alexandru","orcid":"https://orcid.org/0000-0003-3868-5378","observed_orcids":["https://orcid.org/0000-0003-3868-5378"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Oana Alexandru","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081779459","display_name":"Monica Bani\u0163\u0103","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28109999","display_name":"University of Medicine and Pharmacy of Craiova","ror":"https://ror.org/031d5vw30","country_code":"RO","type":"education","lineage":["https://openalex.org/I28109999"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Monica Banita","raw_affiliation_strings":["University of Medicine and Pharmacy, Craiova, Romania","University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Pharmacy, Craiova, Romania","institution_ids":["https://openalex.org/I28109999"]},{"raw_affiliation_string":"University of Medicine and Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108349457","display_name":"C\u0103t\u0103lina Gabriela Pisoschi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28109999","display_name":"University of Medicine and Pharmacy of Craiova","ror":"https://ror.org/031d5vw30","country_code":"RO","type":"education","lineage":["https://openalex.org/I28109999"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Catalina Pisoschi","raw_affiliation_strings":["University of Medicine and Pharmacy, Craiova, Romania","University of Medicine and Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Medicine and Pharmacy, Craiova, Romania","institution_ids":["https://openalex.org/I28109999"]},{"raw_affiliation_string":"University of Medicine and Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025791635","display_name":"L. Magnus B\u00e4cklund","orcid":"https://orcid.org/0000-0003-0397-6538","observed_orcids":["https://orcid.org/0000-0003-0397-6538"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Magnus L. B\u00e4cklund","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087206674","display_name":"Rolf Lewensohn","orcid":"https://orcid.org/0000-0002-9941-9172","observed_orcids":["https://orcid.org/0000-0002-9941-9172"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rolf Lewensohn","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090024509","display_name":"Anica Dricu","orcid":"https://orcid.org/0000-0002-3039-857X","observed_orcids":["https://orcid.org/0000-0002-3039-857X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anica Dricu","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital, R8:00, Stockholm, 171 76, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Cancer Center Karolinska and Radiumhemmet Karolinska Institute/University Hospital","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090024509"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.8937,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.75304588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"85","issue":"3","first_page":"245","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pdgfr","display_name":"PDGFR","score":0.9440000057220459},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9629999995231628},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8050000071525574},{"id":"https://openalex.org/keywords/jnk1","display_name":"JNK1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.722000002861023},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.8306900262832642},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.6635969877243042},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5628364682197571},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.5415804982185364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.540706217288971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5257316827774048},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5219278335571289},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4892139434814453},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4735355079174042},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45476678013801575},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.426751047372818},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4260895252227783},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3955041766166687},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37441736459732056},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3247529864311218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22212734818458557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13507163524627686},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.13228031992912292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048055","descriptor_name":"Mitogen-Activated Protein Kinase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11060-007-9417-0","doi":"https://doi.org/10.1007/s11060-007-9417-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11060-007-9417-0","pdf_url":null,"source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},{"id":"pmid:17568996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17568996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuro-oncology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W164445532","https://openalex.org/W1555073840","https://openalex.org/W1610128693","https://openalex.org/W1843891279","https://openalex.org/W1916093870","https://openalex.org/W1972279606","https://openalex.org/W2023777764","https://openalex.org/W2024977477","https://openalex.org/W2029320277","https://openalex.org/W2031436850","https://openalex.org/W2031749466","https://openalex.org/W2050585969","https://openalex.org/W2054101759","https://openalex.org/W2058707578","https://openalex.org/W2064325114","https://openalex.org/W2071699271","https://openalex.org/W2071791445","https://openalex.org/W2075004606","https://openalex.org/W2075338210","https://openalex.org/W2076515532","https://openalex.org/W2080664885","https://openalex.org/W2085850984","https://openalex.org/W2086310101","https://openalex.org/W2094825902","https://openalex.org/W2098341282","https://openalex.org/W2100937050","https://openalex.org/W2116032190","https://openalex.org/W2118364944","https://openalex.org/W2122528173","https://openalex.org/W2131862721","https://openalex.org/W2141977548","https://openalex.org/W2143973559","https://openalex.org/W2163890769","https://openalex.org/W2171074230","https://openalex.org/W2417086263","https://openalex.org/W4244344354"],"related_works":["https://openalex.org/W1489631572","https://openalex.org/W1553290483","https://openalex.org/W2974686203","https://openalex.org/W2982623693","https://openalex.org/W2161279318","https://openalex.org/W2582705071","https://openalex.org/W1972624341","https://openalex.org/W2094825902","https://openalex.org/W1964572311","https://openalex.org/W1128580846"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}