{"id":"https://openalex.org/W1983199304","doi":"https://doi.org/10.1016/j.febslet.2007.06.018","title":"Oxygen, a source of life and stress","display_name":"Oxygen, a source of life and stress","publication_year":2007,"publication_date":"2007-06-19","ids":{"openalex":"https://openalex.org/W1983199304","doi":"https://doi.org/10.1016/j.febslet.2007.06.018","mag":"1983199304","pmid":"https://pubmed.ncbi.nlm.nih.gov/17586500"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2007.06.018","doi":"https://doi.org/10.1016/j.febslet.2007.06.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.06.018","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112905087","display_name":"M. Christiane Brahimi-Horn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210151846","display_name":"Centre Antoine Lacassagne","ror":"https://ror.org/05hmfw828","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210151846"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M. Christiane Brahimi-Horn","raw_affiliation_strings":["Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France. brahimi@unice.fr","Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France. brahimi@unice.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210151846"]},{"raw_affiliation_string":"Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210151846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091254505","display_name":"Jacques Pouyss\u00e9gur","orcid":"https://orcid.org/0000-0003-2779-6902","observed_orcids":["https://orcid.org/0000-0003-2779-6902"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210151846","display_name":"Centre Antoine Lacassagne","ror":"https://ror.org/05hmfw828","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210151846"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Pouyss\u00e9gur","raw_affiliation_strings":["Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210151846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112905087"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210151846"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":2.1771,"has_fulltext":false,"cited_by_count":410,"citation_normalized_percentile":{"value":0.89257294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"581","issue":"19","first_page":"3582","last_page":"3591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxygen","display_name":"oxygen","score":0.6629999876022339},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.984000027179718},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oxygen-sensing","display_name":"oxygen sensing","score":0.9879999756813049},{"id":"https://openalex.org/keywords/oxygen-partial-pressure","display_name":"oxygen partial pressure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.7070000171661377},{"id":"https://openalex.org/keywords/ph-control","display_name":"pH control","score":0.9210000038146973},{"id":"https://openalex.org/keywords/retinopathy-of-prematurity","display_name":"retinopathy of prematurity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ischemic-disorders","display_name":"ischemic disorders","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vascular-homeostasis","display_name":"vascular homeostasis","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5960547924041748},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.5039555430412292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4270251989364624},{"id":"https://openalex.org/C2993032594","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Oxygen metabolism","level":3,"score":0.4132651090621948},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.08423677086830139},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07228848338127136},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010313","descriptor_name":"Partial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.febslet.2007.06.018","doi":"https://doi.org/10.1016/j.febslet.2007.06.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.06.018","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:17586500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17586500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00319870v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00319870","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"FEBS Letters, 2007, 581 (19), pp.3582-91. ⟨10.1016/j.febslet.2007.06.018⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1482076735","https://openalex.org/W1568216467","https://openalex.org/W1613477746","https://openalex.org/W1842875237","https://openalex.org/W1963545628","https://openalex.org/W1964312498","https://openalex.org/W1966483924","https://openalex.org/W1977767943","https://openalex.org/W1980475208","https://openalex.org/W1983075687","https://openalex.org/W1987141359","https://openalex.org/W1989673862","https://openalex.org/W1990923495","https://openalex.org/W1992325204","https://openalex.org/W1996497770","https://openalex.org/W2005917601","https://openalex.org/W2007287727","https://openalex.org/W2010967562","https://openalex.org/W2011810742","https://openalex.org/W2019602861","https://openalex.org/W2019789647","https://openalex.org/W2027705428","https://openalex.org/W2031364590","https://openalex.org/W2033958147","https://openalex.org/W2041024692","https://openalex.org/W2041596211","https://openalex.org/W2044190493","https://openalex.org/W2044597300","https://openalex.org/W2046871515","https://openalex.org/W2049676133","https://openalex.org/W2052553321","https://openalex.org/W2054633892","https://openalex.org/W2054987125","https://openalex.org/W2058540317","https://openalex.org/W2058610977","https://openalex.org/W2060315853","https://openalex.org/W2060525294","https://openalex.org/W2061184351","https://openalex.org/W2062515127","https://openalex.org/W2066807386","https://openalex.org/W2069939390","https://openalex.org/W2071264542","https://openalex.org/W2082483448","https://openalex.org/W2084740377","https://openalex.org/W2090627731","https://openalex.org/W2098902167","https://openalex.org/W2099616702","https://openalex.org/W2102799140","https://openalex.org/W2104233141","https://openalex.org/W2109920630","https://openalex.org/W2110090322","https://openalex.org/W2113790366","https://openalex.org/W2115772647","https://openalex.org/W2116766412","https://openalex.org/W2118484233","https://openalex.org/W2119239003","https://openalex.org/W2122826701","https://openalex.org/W2130503287","https://openalex.org/W2130757625","https://openalex.org/W2131964237","https://openalex.org/W2136212424","https://openalex.org/W2142622000","https://openalex.org/W2144323242","https://openalex.org/W2148812205","https://openalex.org/W2153512434","https://openalex.org/W2153948449","https://openalex.org/W2163471981","https://openalex.org/W2165235603","https://openalex.org/W2166932492","https://openalex.org/W4293255619"],"related_works":["https://openalex.org/W2041970102","https://openalex.org/W4245652763","https://openalex.org/W2139439558","https://openalex.org/W1974682192","https://openalex.org/W1602845909","https://openalex.org/W4387669521","https://openalex.org/W4285058656","https://openalex.org/W112730726","https://openalex.org/W3037604111","https://openalex.org/W3009721059"],"abstract_inverted_index":{"Oxygen":[0],"is":[1,77],"an":[2],"essential":[3],"element":[4],"in":[5,34,79,107,121,144],"the":[6,12,27,39,94,103,113,118,126],"survival":[7],"of":[8,14,23,32,41,44,61,93,98,117,124],"complex":[9],"organisms,":[10],"however":[11],"level":[13],"oxygen,":[15],"low":[16],"or":[17],"high,":[18],"can":[19,37,57],"be":[20,38],"a":[21,42],"source":[22],"stress":[24],"depending":[25],"on":[26,136,141],"biological":[28],"context.":[29],"Low":[30],"levels":[31,55],"oxygen":[33,65,68,99,108],"tissues":[35],"(hypoxia)":[36],"consequence":[40],"number":[43],"pathophysiological":[45],"conditions":[46],"including":[47],"ischemic":[48],"disorders":[49],"and":[50,67,74,96,102,115,140,150],"cancer":[51,137],"while":[52],"relative,":[53],"higher":[54],"(hyperoxia)":[56],"lead":[58],"to":[59],"retinopathy":[60],"prematurity.":[62],"The":[63],"local":[64],"environment":[66],"consumption":[69],"dictate":[70],"vascular":[71],"homeostasis,":[72],"vaso-proliferation":[73],"vaso-cessation,":[75],"which":[76],"deregulated":[78],"these":[80],"diseases":[81],"through":[82],"oxygen-dependent":[83],"growth":[84],"factors.":[85],"In":[86,131],"this":[87],"review,":[88],"we":[89,133],"will":[90,111,134],"introduce":[91],"aspects":[92],"physiology":[95],"biology":[97],"partial":[100],"pressure":[101],"molecular":[104],"mechanisms":[105],"implicated":[106],"sensing.":[109],"We":[110],"outline":[112],"regulation":[114,149],"function":[116],"key":[119],"operator":[120],"cellular":[122],"signalling":[123],"hypoxia,":[125],"transcription":[127],"factor,":[128],"hypoxia-inducible":[129],"factor.":[130],"addition,":[132],"focus":[135],"cell":[138,146],"hypoxia":[139],"its":[142],"role":[143],"driving":[145],"metabolism,":[147],"pH":[148],"survival.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":38},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}