{"id":"https://openalex.org/W1983191024","doi":"https://doi.org/10.5352/jls.2011.21.3.400","title":"The Autophagic Response to Exercise Training of the Skeletal Muscle Fibers in Young and Old Mice","display_name":"The Autophagic Response to Exercise Training of the Skeletal Muscle Fibers in Young and Old Mice","publication_year":2011,"publication_date":"2011-03-30","ids":{"openalex":"https://openalex.org/W1983191024","doi":"https://doi.org/10.5352/jls.2011.21.3.400","mag":"1983191024"},"language":"en","primary_location":{"id":"doi:10.5352/jls.2011.21.3.400","doi":"https://doi.org/10.5352/jls.2011.21.3.400","is_oa":true,"landing_page_url":"https://doi.org/10.5352/jls.2011.21.3.400","pdf_url":"http://koreascience.or.kr:80/article/JAKO201122852777776.pdf","source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Life Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO201122852777776.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103174479","display_name":"Yong-An Kim","orcid":"https://orcid.org/0000-0001-5019-1536","observed_orcids":["https://orcid.org/0000-0001-5019-1536"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-An Kim","raw_affiliation_strings":["Department of Biochemistry , College of Natural Sciences , Chungnam Nat'l University , Daejon 305-764 , korea","Intitute of Biotechnology, Chungnam Nat'l Univertisy, Daejon 305-764, korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , College of Natural Sciences , Chungnam Nat'l University , Daejon 305-764 , korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Intitute of Biotechnology, Chungnam Nat'l Univertisy, Daejon 305-764, korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100713608","display_name":"Young\u2010Sang Kim","orcid":"https://orcid.org/0000-0002-7397-5410","observed_orcids":["https://orcid.org/0000-0002-7397-5410"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Sang Kim","raw_affiliation_strings":["Department of Biochemistry , College of Natural Sciences , Chungnam Nat'l University , Daejon 305-764 , korea","Intitute of Biotechnology , Chungnam Nat'l Univertisy , Daejon 305-764 , korea","Chungnam national university"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , College of Natural Sciences , Chungnam Nat'l University , Daejon 305-764 , korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Intitute of Biotechnology , Chungnam Nat'l Univertisy , Daejon 305-764 , korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Chungnam national university","institution_ids":["https://openalex.org/I196345858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I196345858"],"apc_list":null,"apc_paid":null,"fwci":0.7341,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64396999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"3","first_page":"400","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.03229999914765358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.9660000205039978},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9150000214576721},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9649999737739563},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atg7","display_name":"ATG7","score":0.9959999918937683},{"id":"https://openalex.org/keywords/autophagy-related-proteins","display_name":"autophagy-related proteins","score":0.7979999780654907},{"id":"https://openalex.org/keywords/treadmill-running","display_name":"treadmill running","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8679999709129333},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.5490000247955322},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.5350000262260437},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.3140000104904175},{"id":"https://openalex.org/keywords/cellular-homeostasis","display_name":"cellular homeostasis","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8798300623893738},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7141678333282471},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.6555263996124268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5376777052879333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5239301323890686},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.47014549374580383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46824586391448975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3251914978027344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1254306435585022},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1231553852558136}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5352/jls.2011.21.3.400","doi":"https://doi.org/10.5352/jls.2011.21.3.400","is_oa":true,"landing_page_url":"https://doi.org/10.5352/jls.2011.21.3.400","pdf_url":"http://koreascience.or.kr:80/article/JAKO201122852777776.pdf","source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Life Science","raw_type":"journal-article"},{"id":"mag:2143528770","doi":null,"is_oa":false,"landing_page_url":"http://www.dbpia.co.kr/Journal/ArticleDetail/NODE01622433?q=%5Bproduct%20sound%C2%A7coldb%C2%A72%C2%A751%C2%A73%5D&Multimedia=0&isFullText=1&specificParam=0&SearchMethod=0","pdf_url":null,"source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\uc0dd\uba85\uacfc\ud559\ud68c\uc9c0","raw_type":null}],"best_oa_location":{"id":"doi:10.5352/jls.2011.21.3.400","doi":"https://doi.org/10.5352/jls.2011.21.3.400","is_oa":true,"landing_page_url":"https://doi.org/10.5352/jls.2011.21.3.400","pdf_url":"http://koreascience.or.kr:80/article/JAKO201122852777776.pdf","source":{"id":"https://openalex.org/S4210184715","display_name":"Journal of Life Science","issn_l":"1225-9918","issn":["1225-9918","2287-3406"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Life Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983191024.pdf","grobid_xml":"https://content.openalex.org/works/W1983191024.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W202319641","https://openalex.org/W1965470471","https://openalex.org/W1992357172","https://openalex.org/W1995873922","https://openalex.org/W2001591494","https://openalex.org/W2022812113","https://openalex.org/W2027984907","https://openalex.org/W2029783488","https://openalex.org/W2034132952","https://openalex.org/W2036787961","https://openalex.org/W2060792177","https://openalex.org/W2076953907","https://openalex.org/W2080366094","https://openalex.org/W2105504231","https://openalex.org/W2107045511","https://openalex.org/W2115742671","https://openalex.org/W2140664473","https://openalex.org/W2141165347","https://openalex.org/W2143542604","https://openalex.org/W2168212241"],"related_works":["https://openalex.org/W2143528770","https://openalex.org/W3034247192","https://openalex.org/W2041198637","https://openalex.org/W2270064673","https://openalex.org/W2344221796","https://openalex.org/W2330761876","https://openalex.org/W2362033623","https://openalex.org/W6910350333","https://openalex.org/W4225411390","https://openalex.org/W2255039686"],"abstract_inverted_index":{"Autophagy\ub294":[0],"\ud56d\uc0c1\uc131":[1],"\uc720\uc9c0\uc640":[2],"\uc2a4\ud2b8\ub808\uc2a4\ubc18\uc751\uc744":[3],"\ud6a8\uc728\uc801\uc73c\ub85c":[4],"\uc870\uc815\ud558\uae30":[5],"\uc704\ud574":[6,45],"\ud544\uc218\uc801\uc778":[7],"\uc138\ud3ec":[8,22],"\ub0b4":[9,23],"\uc9c8\uc801":[10],"\uc870\uc808\uc791\uc6a9\uc774\ub2e4.":[11],"\ub178\ud654\uac00":[12],"\uc9c4\ud589\ub418\ub294":[13],"\ub3d9\uc548":[14],"autopahgy\uc5d0":[15],"\uc758\ud55c":[16,37],"degradation":[17,148],"\ud6a8\uc728\uc131":[18],"\uc800\ud558\uc640":[19],"\uadf8\ub85c":[20],"\uc778\ud55c":[21],"\ubd80\uc0b0\ubb3c\uc758":[24],"\ucd95\uc801\uc774":[25],"\uc99d\uac00\ud558\uc5ec":[26],"\uacb0\uad6d,":[27],"\uadfc\uc721\uc758":[28],"\uc57d\ud654\ub97c":[29],"\ucd08\ub798\ud55c\ub2e4.":[30],"\uadf8\ub7ec\ubbc0\ub85c":[31],"\ubcf8":[32],"\uc5f0\uad6c\uc758":[33],"\ubaa9\uc801\uc740":[34],"\uace8\uaca9\uadfc\uc5d0\uc11c":[35],"\uc6b4\ub3d9\uc5d0":[36,92,107],"autopahgy":[38,72,104],"\uad00\ub828":[39,73,95],"\ub2e8\ubc31\uc9c8\uc758":[40],"\ubcc0\ud654\ub97c":[41],"\uaddc\uba85\ud558\ub294\ub370":[42],"\uc788\ub2e4.":[43],"\uc774\ub97c":[44],"24\ub9c8\ub9ac\uc758":[46],"Young":[47,78,175],"\uadf8\ub8f9\uacfc":[48,79],"Old":[49,81,179,264,288,303,325],"\uadf8\ub8f9\uc744":[50],"\ub098\ub204\uc5b4":[51],"\uac01\uac01":[52],"\ub300\uc870\uad70(n=6)\uacfc":[53],"\uc6b4\ub3d9\uad70(n=6)\uc73c\ub85c":[54],"\ubc30\uc815\ud558\uc600\ub2e4.":[55],"\uc6b4\ub3d9\uc740":[56],"8\uc8fc\uac04":[57],"\uc8fc":[58],"5\ud68c":[59],"\uc2e4\uc2dc\ud558\uc600\uace0,":[60],"\ud2b8\ub808\ub4dc\ubc00":[61],"\uc18d\ub3c4":[62],"16.4":[63,213],"m/min\uc640":[64],"\uacbd\uc0ac\ub3c4":[65],"4%\ub85c":[66],"\uc124\uc815\ud558\uc5ec":[67],"40\ubd84\uac04":[68],"\uc9c0\uc18d\uc801\uc778":[69],"\uc6b4\ub3d9\uc744":[70],"\uc2e4\uc2dc\ud558\uc600\ub2e4.":[71],"\ub2e8\ubc31\uc9c8\uc5d0":[74],"\ub300\ud55c":[75],"\uac80\uc99d":[76],"\uacb0\uacfc":[77],"\ube44\uad50\ud558\uc5ec":[80],"\uadf8\ub8f9\uc5d0\uc11c":[82],"LC3-1,":[83],"Beclin-1,":[84],"Atg7\uc740":[85],"\ubaa8\ub450":[86],"\uc720\uc758\ud558\uac8c":[87],"\uac10\uc18c\ud558\uc600\ub2e4.":[88],"\uadf8\ub7ec\ub098":[89],"8\uc8fc\uac04\uc758":[90],"\uaddc\uce59\uc801\uc778":[91,106],"\uc758\ud558\uc5ec":[93],"autophagy":[94,253,318],"\ub2e8\ubc31\uc9c8\uc740":[96],"\uc99d\uac00\ud558\ub294":[97],"\uac83\uc73c\ub85c":[98,112],"\ub098\ud0c0\ub0ac\ub2e4.":[99],"\ub530\ub77c\uc11c":[100],"\ub178\ud654\uc5d0":[101],"\uc758\ud574":[102,108],"\uc57d\ud654\ub41c":[103],"\uae30\ub2a5\uc740":[105],"\uac1c\uc120\ub420":[109],"\uc218":[110],"\uc788\uc744":[111],"\uc0ac\ub8cc\ub41c\ub2e4.":[113],"Autophagy,":[114],"a":[115,189,216],"highly":[116],"conserved":[117],"mechanism":[118],"of":[119,128,135,146,158,166,204,209,238,251],"internal":[120],"quality":[121],"control,":[122],"is":[123,161],"essential":[124],"for":[125,132,224],"the":[126,133,144,156,164,235,242,257,263,268,277,287,292,301,322],"maintenance":[127],"cellular":[129,138],"homeostasis":[130],"and":[131,150,178,194,221,282],"orchestration":[134],"an":[136,201],"efficient":[137],"response":[139,170],"to":[140,162,267,291],"stress.":[141],"During":[142],"aging,":[143],"efficiency":[145],"autophagic":[147,169],"declines":[149],"intracellular":[151],"waste":[152],"products":[153],"accumulate.":[154],"Therefore,":[155],"aim":[157],"this":[159],"study":[160],"investigate":[163],"effects":[165],"exercise":[167,195,274,333],"on":[168,312],"in":[171,262,276,286,300,324],"skeletal":[172,244],"muscle.":[173],"Twenty-four":[174],"(4":[176],"month)":[177,181],"(12":[180],"ICR-type":[182],"white":[183],"male":[184],"mice":[185,265,289,304],"were":[186,246,284],"divided":[187],"into":[188],"control":[190],"group":[191,197],"(CON:":[192],"n=6)":[193,199],"training":[196,275],"(Tr:":[198],"after":[200,234,240],"adaptation":[202],"period":[203],"1":[205],"week.":[206],"Exercise":[207],"consisted":[208],"treadmill":[210],"running":[211],"at":[212,231],"m/min":[214],"with":[215,273,332],"4%":[217],"incline,":[218],"40":[219],"min/day":[220],"5":[222],"days/week":[223],"8":[225],"weeks.":[226],"Cervical":[227],"dislocation":[228],"was":[229,260,297],"performed":[230],"48":[232],"hours":[233],"last":[236],"round":[237],"exercise,":[239],"which":[241],"gastrocnemius":[243],"muscle":[245],"immediately":[247],"collected.":[248],"The":[249],"results":[250],"verifying":[252],"formation":[254],"showed":[255],"that":[256,317,328],"Sarcopenia":[258],"index":[259],"decreased":[261,285],"compared":[266,290],"Young.":[269,293],"However,":[270,294],"it":[271],"increased":[272,299],"Old.":[278],"Lipidation":[279,295],"LC3-II,":[280],"Becline-1,":[281],"Atg7":[283],"LC3-II":[296],"significantly":[298],"trained":[302],"(Young:1":[305],"Vs":[306],"Old:":[307],"$1.32{\\pm}0.042$":[308],",":[309],"p<0.05).":[310],"Based":[311],"these":[313],"data,":[314],"we":[315],"suggest":[316],"regulatory":[319],"events":[320],"are":[321,330],"attenuated":[323],"mice,":[326],"but":[327],"they":[329],"enhanced":[331],"training.":[334]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}