{"id":"https://openalex.org/W1983183071","doi":"https://doi.org/10.1021/bi00007a030","title":"Molecular Interactions of 3',5'-Cyclic Purine Analogs with the Binding Site of Retinal Rod Ion Channels","display_name":"Molecular Interactions of 3',5'-Cyclic Purine Analogs with the Binding Site of Retinal Rod Ion Channels","publication_year":1995,"publication_date":"1995-02-12","ids":{"openalex":"https://openalex.org/W1983183071","doi":"https://doi.org/10.1021/bi00007a030","mag":"1983183071","pmid":"https://pubmed.ncbi.nlm.nih.gov/7532007"},"language":"en","primary_location":{"id":"doi:10.1021/bi00007a030","doi":"https://doi.org/10.1021/bi00007a030","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00007a030","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030546377","display_name":"Sean\u2010Patrick Scott","orcid":"https://orcid.org/0000-0002-8480-1547","observed_orcids":["https://orcid.org/0000-0002-8480-1547"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean-Patrick Scott","raw_affiliation_strings":["Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108693784","display_name":"Jacqueline C. Tanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline C. Tanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8671,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.70870871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"7","first_page":"2338","last_page":"2347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6791999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclic-amp-analogues","display_name":"cyclic AMP analogs","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.7110000252723694},{"id":"https://openalex.org/keywords/camp-binding-sites","display_name":"cAMP binding sites","score":0.32199999690055847},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.48399999737739563},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6510000228881836},{"id":"https://openalex.org/keywords/phototransduction","display_name":"phototransduction","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.6719036102294922},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6200639009475708},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5352030396461487},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5284138917922974},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4941296875476837},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4799509346485138},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.47643929719924927},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42621150612831116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29164737462997437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1569039225578308},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08549651503562927},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07731953263282776},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06707599759101868}],"mesh":[{"descriptor_ui":"D000557","descriptor_name":"Ambystoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054815","descriptor_name":"Cyclic Nucleotide-Gated Cation Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00007a030","doi":"https://doi.org/10.1021/bi00007a030","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00007a030","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7532007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7532007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G589194517","display_name":null,"funder_award_id":"EY06640","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079129494","https://openalex.org/W4393973293","https://openalex.org/W2020305917","https://openalex.org/W1986393620","https://openalex.org/W1966616037","https://openalex.org/W1967380684","https://openalex.org/W2065644272","https://openalex.org/W2016688851","https://openalex.org/W2089091257","https://openalex.org/W2030943487"],"abstract_inverted_index":{"Photoreceptor":[0],"outer":[1],"segments":[2],"transduce":[3],"information":[4],"about":[5],"incoming":[6],"light":[7],"levels":[8],"through":[9],"a":[10,84,146,221],"class":[11],"of":[12,28,80,117,149,211,224,230,251,280,310,315,327],"ion":[13],"channels":[14],"that":[15,181,261],"respond":[16],"directly":[17],"to":[18,43,107,177,195,207,254,295],"changes":[19,199],"in":[20,60,83,105,186,200,312],"cytosolic":[21],"3',5'-cyclic":[22,29],"guanosine":[23],"monophosphate":[24],"levels.":[25],"A":[26],"series":[27],"purine":[30,278],"analogues":[31,59,91,159,214,263],"with":[32,99,154,160,183,300],"alterations":[33,161],"at":[34,162,331],"N1,":[35],"C2,":[36],"C6,":[37],"or":[38,164,333],"C8":[39],"positions":[40,166],"was":[41,64,86,104,126,245,293],"used":[42],"examine":[44],"molecular":[45,209,222],"interactions":[46,182,299],"between":[47,276],"the":[48,51,67,73,75,81,96,150,178,184,198,212,225,231,248,262,268,277,283,289,316,323],"nucleotide":[49,227],"and":[50,72,143,172,203,217,239,282,306],"channel.":[52,233],"The":[53,114,308],"maximal":[54,201],"current":[55,68,82,94,153,202],"activated":[56,69,92,145],"by":[57,70,237,322],"C2-altered":[58],"excised":[61],"membrane":[62],"patches":[63],"less":[65],"than":[66,95],"cGMP,":[71,208],"K0.5,":[74],"concentration":[76],"which":[77,109,328],"activates":[78],"50%":[79],"patch,":[85],"increased.":[87],"Nonpolar":[88],"C8-substituted":[89],"cAMP":[90,98,135,252,281,305],"more":[93],"parent":[97],"lower":[100],"K0.5":[101,121,156,204],"values.":[102,157],"This":[103,234],"contrast":[106],"8-amino-cAMP,":[108],"exhibited":[110],"greatly":[111],"reduced":[112],"activity.":[113],"rank":[115],"order":[116,194],"activity,":[118],"based":[119,246],"on":[120,247,288,303],"values,":[122],"for":[123,191],"C8-cAMP":[124],"substituents":[125,302],"as":[127],"follows:":[128],"8-azido-":[129],">":[130,132,134,136,138],"8-methylamino-":[131],"8-benzylamino-":[133],"8-bromo-":[137],"8-hydroxy-":[139],">>":[140],"8-amino-cAMP.":[141],"1,N6-Etheno-cAMP":[142],"N6-monobutyryl-cAMP":[144],"small":[147],"fraction":[148],"total":[151],"possible":[152],"high":[155],"Other":[158],"N1":[163,332],"C6":[165,301],"including":[167],"N1-oxide-cAMP,":[168],"2-aminopurine":[169],"riboside":[170],"3',5'-monophosphate,":[171],"N6-monosuccinyl-cAMP":[173],"do":[174],"not":[175],"bind":[176],"channel,":[179],"suggesting":[180],"channel":[185],"this":[187,313],"region":[188,314],"are":[189,329],"essential":[190],"binding.":[192],"In":[193],"help":[196],"interpret":[197],"values":[205],"compared":[206],"models":[210],"active":[213],"were":[215,264,274],"constructed":[216],"then":[218],"docked":[219],"into":[220],"model":[223],"cyclic":[226],"binding":[228,269,317],"site":[229],"retinal":[232],"model,":[235],"proposed":[236],"Kumar":[238],"Weber":[240],"[(1992)":[241],"Biochemistry":[242],"31,":[243],"4643-4649],":[244],"crystal":[249],"structure":[250],"bound":[253],"catabolite":[255],"activator":[256],"protein.":[257],"Our":[258],"modeling":[259],"showed":[260],"sterically":[265],"accommodated":[266],"within":[267],"site.":[270],"No":[271],"hydrogen":[272],"bonds":[273],"predicted":[275,294],"rings":[279],"pocket;":[284],"however,":[285],"Phe":[286],"533":[287],"beta":[290],"5":[291],"strand":[292],"form":[296],"weak":[297],"electrostatic":[298],"both":[304],"cGMP.":[307],"importance":[309],"contacts":[311],"pocket":[318],"is":[319],"further":[320],"emphasized":[321],"inactive":[324],"analogues,":[325],"all":[326],"altered":[330],"C6.":[334]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}