{"id":"https://openalex.org/W1983153105","doi":"https://doi.org/10.1111/j.1530-0277.1986.tb05087.x","title":"Human Aldehyde Dehydrogenase: Kinetic Identification of the Isozyme for Which Biogenic Aldehydes and Acetaldehyde Compete","display_name":"Human Aldehyde Dehydrogenase: Kinetic Identification of the Isozyme for Which Biogenic Aldehydes and Acetaldehyde Compete","publication_year":1986,"publication_date":"1986-05-01","ids":{"openalex":"https://openalex.org/W1983153105","doi":"https://doi.org/10.1111/j.1530-0277.1986.tb05087.x","mag":"1983153105","pmid":"https://pubmed.ncbi.nlm.nih.gov/3526948"},"language":"en","primary_location":{"id":"doi:10.1111/j.1530-0277.1986.tb05087.x","doi":"https://doi.org/10.1111/j.1530-0277.1986.tb05087.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1986.tb05087.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056944006","display_name":"Alexander D. MacKerell","orcid":"https://orcid.org/0000-0001-8287-6804","observed_orcids":["https://orcid.org/0000-0001-8287-6804","https://orcid.org/0000-0003-4290-182X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander D. MacKerell","raw_affiliation_strings":["Center of Alcohol Studies, Rutgers University, Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Alcohol Studies, Rutgers University, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026853013","display_name":"Erich E. Blatter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erich E. Blatter","raw_affiliation_strings":["Center of Alcohol Studies, Rutgers University , Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Alcohol Studies, Rutgers University , Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088006458","display_name":"Regina Pietruszko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Regina Pietruszko","raw_affiliation_strings":["Center of Alcohol Studies, Rutgers University, Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Alcohol Studies, Rutgers University, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088006458"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":4.356,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.94257356,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"3","first_page":"266","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/michaelis-constant","display_name":"Michaelis constant","score":0.6209999918937683},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/phenylacetaldehyde","display_name":"phenylacetaldehyde","score":0.8479999899864197},{"id":"https://openalex.org/keywords/3-4-dihydroxyphenylacetaldehyde","display_name":"DOPAL","score":0.9829999804496765},{"id":"https://openalex.org/keywords/acetaldehyde","display_name":"acetaldehyde","score":0.6930000185966492},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.6629999876022339},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5910000205039978},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777595113","wikidata":"https://www.wikidata.org/wiki/Q61457","display_name":"Acetaldehyde","level":3,"score":0.9226129651069641},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8340249061584473},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.817612886428833},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.7041122317314148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5636329650878906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5437941551208496},{"id":"https://openalex.org/C2777934754","wikidata":"https://www.wikidata.org/wiki/Q424998","display_name":"Phenylacetaldehyde","level":2,"score":0.510347306728363},{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.4964507222175598},{"id":"https://openalex.org/C2779825165","wikidata":"https://www.wikidata.org/wiki/Q101497","display_name":"Aldehyde","level":3,"score":0.455557644367218},{"id":"https://openalex.org/C3175096","wikidata":"https://www.wikidata.org/wiki/Q2640417","display_name":"ALDH2","level":4,"score":0.41056010127067566},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34049975872039795},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3043816089630127},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.16423481702804565},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.10452994704246521}],"mesh":[{"descriptor_ui":"D000079","descriptor_name":"Acetaldehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1530-0277.1986.tb05087.x","doi":"https://doi.org/10.1111/j.1530-0277.1986.tb05087.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1986.tb05087.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:3526948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3526948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4565035239","display_name":null,"funder_award_id":"K02-AA00046","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G468927466","display_name":"HUMAN ALDEHYDE DEHYDROGENASE:  RELEVANCE TO ALCOHOLISM","funder_award_id":"5k02aa000046-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G964278560","display_name":null,"funder_award_id":"AA 00186","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1480651372","https://openalex.org/W1514312266","https://openalex.org/W1563874445","https://openalex.org/W1589027452","https://openalex.org/W1775749144","https://openalex.org/W1965158345","https://openalex.org/W1970883066","https://openalex.org/W1972816445","https://openalex.org/W1982656652","https://openalex.org/W1995928877","https://openalex.org/W2006270354","https://openalex.org/W2017203180","https://openalex.org/W2022446050","https://openalex.org/W2026635928","https://openalex.org/W2043969745","https://openalex.org/W2044240568","https://openalex.org/W2054979333","https://openalex.org/W2056449173","https://openalex.org/W2057430568","https://openalex.org/W2064852077","https://openalex.org/W2085872902","https://openalex.org/W2201784617","https://openalex.org/W2226650945","https://openalex.org/W2338215092","https://openalex.org/W2397588468","https://openalex.org/W2397861637","https://openalex.org/W2417122939","https://openalex.org/W2417944988","https://openalex.org/W4289965571"],"related_works":["https://openalex.org/W2051964656","https://openalex.org/W1565629087","https://openalex.org/W2070001837","https://openalex.org/W2049584032","https://openalex.org/W2421495306","https://openalex.org/W2052774926","https://openalex.org/W2024226038","https://openalex.org/W105085748","https://openalex.org/W2082697400","https://openalex.org/W69932396"],"abstract_inverted_index":{"Michaelis":[0],"constants":[1,49,72],"and":[2,22,28,37,91],"maximal":[3],"velocities":[4],"for":[5,33,58],"phenylacetaldehyde":[6],"(a":[7,12,18,24],"metabolite":[8,13,19,25],"of":[9,14,20,26,41,62,70,85,96],"phenylethylamine),":[10],"3,4-dihydroxyphenylacetaldehyde":[11],"dopamine),":[15],"5-hydroxyindole":[16],"acetaldehyde":[17,77],"serotonin),":[21],"3,4-dihydroxyphenylglycolaldehyde":[23],"epinephrine":[27],"norepinephrine)":[29],"have":[30,53],"been":[31,55],"determined":[32,57],"both":[34],"cytoplasmic":[35,94],"(E1)":[36],"mitochondrial":[38,90],"(E2)":[39],"isozymes":[40,61],"human":[42,97],"liver":[43,98],"aldehyde":[44,63,99],"dehydrogenase":[45,64],"(EC":[46],"1.2.1.3).":[47],"Kinetic":[48],"with":[50,76,88],"biogenic":[51,86],"aldehydes":[52,87],"never":[54],"previously":[56],"individual":[59],"homogeneous":[60],"from":[65],"any":[66],"species.":[67],"Mathematical":[68],"treatment":[69],"these":[71],"suggests":[73],"that":[74],"competition":[75],"during":[78],"alcohol":[79],"metabolism":[80],"would":[81],"severely":[82],"inhibit":[83],"dehydrogenation":[84],"the":[89,93],"not":[92],"isozyme":[95],"dehydrogenase.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
