{"id":"https://openalex.org/W1983146273","doi":"https://doi.org/10.1016/s0304-3835(02)00241-0","title":"A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy","display_name":"A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W1983146273","doi":"https://doi.org/10.1016/s0304-3835(02)00241-0","mag":"1983146273","pmid":"https://pubmed.ncbi.nlm.nih.gov/12127690"},"language":"en","primary_location":{"id":"doi:10.1016/s0304-3835(02)00241-0","doi":"https://doi.org/10.1016/s0304-3835(02)00241-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3835(02)00241-0","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033234706","display_name":"Yujun Pan","orcid":"https://orcid.org/0000-0002-3727-0114","observed_orcids":["https://orcid.org/0000-0002-3727-0114"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yujun Pan","raw_affiliation_strings":["Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. yujun-pan@omrf.ouhsc.edu","Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. yujun-pan@omrf.ouhsc.edu","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101565828","display_name":"Peng Cheng Zhai","orcid":"https://orcid.org/0000-0001-6196-2658","observed_orcids":["https://orcid.org/0000-0001-6196-2658"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Zhai","raw_affiliation_strings":["Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111687586","display_name":"Azar Dashti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Azar M Dashti","raw_affiliation_strings":["Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017425857","display_name":"Shili Wu","orcid":"https://orcid.org/0009-0001-9266-0799","observed_orcids":["https://orcid.org/0009-0001-9266-0799"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shili Wu","raw_affiliation_strings":["Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090285339","display_name":"Xinli Lin","orcid":"https://orcid.org/0000-0002-5420-7264","observed_orcids":["https://orcid.org/0000-0002-5420-7264"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinli Lin","raw_affiliation_strings":["Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Proteomics Laboratory, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":null,"display_name":"Min Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Wu","raw_affiliation_strings":["University of Florida, College of Medicine, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033234706"],"corresponding_institution_ids":["https://openalex.org/I30558944"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":0.4472,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.60249265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"2","first_page":"179","last_page":"188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7200000286102295},{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cotransduction","display_name":"cotransduction","score":0.8220000267028809},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/herpes-simplex-virus-thymidine-kinase","display_name":"herpes simplex virus thymidine kinase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lacz-reporter","display_name":"lacZ reporter","score":0.578000009059906},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.8532075881958008},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8346469402313232},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.7370104789733887},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6691761016845703},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6421555280685425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.515310525894165},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5130337476730347},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.46518224477767944},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.4155226945877075},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4100008010864258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.330959677696228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2360457479953766},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07777523994445801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015750","descriptor_name":"Genes, gag","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015751","descriptor_name":"Genes, pol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0304-3835(02)00241-0","doi":"https://doi.org/10.1016/s0304-3835(02)00241-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0304-3835(02)00241-0","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:12127690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12127690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1565284380","https://openalex.org/W1812073825","https://openalex.org/W1821941363","https://openalex.org/W1913924834","https://openalex.org/W1965319333","https://openalex.org/W1968912221","https://openalex.org/W1975528602","https://openalex.org/W1977340788","https://openalex.org/W1977961016","https://openalex.org/W1981150156","https://openalex.org/W1983682307","https://openalex.org/W2011159084","https://openalex.org/W2016138321","https://openalex.org/W2031892291","https://openalex.org/W2038542456","https://openalex.org/W2040312561","https://openalex.org/W2058503719","https://openalex.org/W2065354528","https://openalex.org/W2071763225","https://openalex.org/W2073949850","https://openalex.org/W2093942071","https://openalex.org/W2108724455","https://openalex.org/W2141354154","https://openalex.org/W2143729842","https://openalex.org/W2161545291","https://openalex.org/W2330462257","https://openalex.org/W2413608033","https://openalex.org/W4255983032"],"related_works":["https://openalex.org/W1972920141","https://openalex.org/W2319106492","https://openalex.org/W2354418388","https://openalex.org/W2414987769","https://openalex.org/W2087133379","https://openalex.org/W1812073825","https://openalex.org/W2341926530","https://openalex.org/W2013868082","https://openalex.org/W1604073273","https://openalex.org/W2350238980"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}