{"id":"https://openalex.org/W1983118346","doi":"https://doi.org/10.1016/j.ceca.2003.10.018","title":"Structure\u2013function relationship of the extracellular calcium-sensing receptor","display_name":"Structure\u2013function relationship of the extracellular calcium-sensing receptor","publication_year":2004,"publication_date":"2004-01-22","ids":{"openalex":"https://openalex.org/W1983118346","doi":"https://doi.org/10.1016/j.ceca.2003.10.018","mag":"1983118346","pmid":"https://pubmed.ncbi.nlm.nih.gov/15200143"},"language":"en","primary_location":{"id":"doi:10.1016/j.ceca.2003.10.018","doi":"https://doi.org/10.1016/j.ceca.2003.10.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ceca.2003.10.018","pdf_url":null,"source":{"id":"https://openalex.org/S80202938","display_name":"Cell Calcium","issn_l":"0143-4160","issn":["0143-4160","1532-1991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Calcium","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113058252","display_name":"Mei Bai","orcid":"https://orcid.org/0000-0003-1960-2071","observed_orcids":["https://orcid.org/0000-0003-1960-2071"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mei Bai","raw_affiliation_strings":["Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, USA. mbai@rics.bwh.harvard.edu","Brigham and Women's Hospital Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, USA. mbai@rics.bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital Harvard Medical School","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113058252"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":null,"fwci":0.8786,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"3","first_page":"197","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-sensing-receptor","display_name":"calcium-sensing receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.8429999947547913},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/extracellular-calcium-sensing","display_name":"extracellular calcium sensing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.7620000243186951},{"id":"https://openalex.org/keywords/familial-hypocalciuric-hypercalcemia","display_name":"familial hypocalciuric hypercalcemia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neonatal-severe-hyperparathyroidism","display_name":"neonatal severe hyperparathyroidism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parathyroid-hormone-regulation","display_name":"parathyroid hormone regulation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.5529999732971191},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C142590548","wikidata":"https://www.wikidata.org/wiki/Q417801","display_name":"Calcium-sensing receptor","level":4,"score":0.9197761416435242},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.8262686729431152},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6166337728500366},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5112261772155762},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5071296691894531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5049267411231995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4948517680168152},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4722763001918793},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4528542160987854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3496875762939453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30691927671432495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28243327140808105},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.2030983865261078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1569913923740387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12784376740455627}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003553","descriptor_name":"Cystine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044169","descriptor_name":"Receptors, Calcium-Sensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044169","descriptor_name":"Receptors, Calcium-Sensing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044169","descriptor_name":"Receptors, Calcium-Sensing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ceca.2003.10.018","doi":"https://doi.org/10.1016/j.ceca.2003.10.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ceca.2003.10.018","pdf_url":null,"source":{"id":"https://openalex.org/S80202938","display_name":"Cell Calcium","issn_l":"0143-4160","issn":["0143-4160","1532-1991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Calcium","raw_type":"journal-article"},{"id":"pmid:15200143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15200143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell calcium","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W85141871","https://openalex.org/W188200808","https://openalex.org/W192047470","https://openalex.org/W263812101","https://openalex.org/W1552563052","https://openalex.org/W1571586310","https://openalex.org/W1577482132","https://openalex.org/W1586082476","https://openalex.org/W1601632182","https://openalex.org/W1654156243","https://openalex.org/W1860030011","https://openalex.org/W1880336884","https://openalex.org/W1893612865","https://openalex.org/W1945680072","https://openalex.org/W1951351840","https://openalex.org/W1964661661","https://openalex.org/W1966949090","https://openalex.org/W1969201146","https://openalex.org/W1969762570","https://openalex.org/W1970549384","https://openalex.org/W1971284998","https://openalex.org/W1972065681","https://openalex.org/W1972183007","https://openalex.org/W1972864808","https://openalex.org/W1974152360","https://openalex.org/W1975608515","https://openalex.org/W1980823413","https://openalex.org/W1982799552","https://openalex.org/W1984875786","https://openalex.org/W1985243710","https://openalex.org/W1986702099","https://openalex.org/W1987798906","https://openalex.org/W1988182516","https://openalex.org/W1989400255","https://openalex.org/W1991481111","https://openalex.org/W1993320200","https://openalex.org/W1994494042","https://openalex.org/W1994723791","https://openalex.org/W1998850010","https://openalex.org/W2005637545","https://openalex.org/W2005913521","https://openalex.org/W2006103051","https://openalex.org/W2007051067","https://openalex.org/W2009181911","https://openalex.org/W2009441758","https://openalex.org/W2010599278","https://openalex.org/W2011683638","https://openalex.org/W2011700237","https://openalex.org/W2016770664","https://openalex.org/W2020237534","https://openalex.org/W2020780052","https://openalex.org/W2027250517","https://openalex.org/W2027466826","https://openalex.org/W2029054871","https://openalex.org/W2029291782","https://openalex.org/W2033252391","https://openalex.org/W2034819530","https://openalex.org/W2035995595","https://openalex.org/W2043166209","https://openalex.org/W2046161078","https://openalex.org/W2049914524","https://openalex.org/W2056403651","https://openalex.org/W2059313753","https://openalex.org/W2061281426","https://openalex.org/W2061798540","https://openalex.org/W2063079988","https://openalex.org/W2065390805","https://openalex.org/W2066439205","https://openalex.org/W2067466593","https://openalex.org/W2067622424","https://openalex.org/W2067889691","https://openalex.org/W2068168873","https://openalex.org/W2068645665","https://openalex.org/W2070372666","https://openalex.org/W2074422382","https://openalex.org/W2075307506","https://openalex.org/W2077973233","https://openalex.org/W2079230562","https://openalex.org/W2080191250","https://openalex.org/W2081227689","https://openalex.org/W2083763646","https://openalex.org/W2086766564","https://openalex.org/W2092134780","https://openalex.org/W2095441352","https://openalex.org/W2098661969","https://openalex.org/W2100443187","https://openalex.org/W2103871176","https://openalex.org/W2106856165","https://openalex.org/W2109206081","https://openalex.org/W2110469184","https://openalex.org/W2111616246","https://openalex.org/W2134579109","https://openalex.org/W2140585727","https://openalex.org/W2141696128","https://openalex.org/W2142120402","https://openalex.org/W2145930493","https://openalex.org/W2150335133","https://openalex.org/W2153170303","https://openalex.org/W2155565935","https://openalex.org/W2157138210","https://openalex.org/W2167767264","https://openalex.org/W2170949021","https://openalex.org/W2171206143","https://openalex.org/W2171485972","https://openalex.org/W2311039579","https://openalex.org/W2317261631","https://openalex.org/W2326971455","https://openalex.org/W2401617433","https://openalex.org/W2412383159","https://openalex.org/W2503230560","https://openalex.org/W2905105757","https://openalex.org/W6634459202","https://openalex.org/W6634850517","https://openalex.org/W6712697974"],"related_works":["https://openalex.org/W1984372830","https://openalex.org/W2152616913","https://openalex.org/W1972065681","https://openalex.org/W1963580328","https://openalex.org/W2371101931","https://openalex.org/W2125348048","https://openalex.org/W1971284998","https://openalex.org/W11883326","https://openalex.org/W2950645245","https://openalex.org/W1967937313"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}