{"id":"https://openalex.org/W1983108555","doi":"https://doi.org/10.1016/s0014-5793(97)01416-6","title":"Glyoxalase II from A. thaliana requires Zn(II) for catalytic activity","display_name":"Glyoxalase II from A. thaliana requires Zn(II) for catalytic activity","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W1983108555","doi":"https://doi.org/10.1016/s0014-5793(97)01416-6","mag":"1983108555","pmid":"https://pubmed.ncbi.nlm.nih.gov/9428743"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-5793(97)01416-6","doi":"https://doi.org/10.1016/s0014-5793(97)01416-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(97)01416-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2897%2901416-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2897%2901416-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007268290","display_name":"Michael W. Crowder","orcid":"https://orcid.org/0000-0002-3138-0283","observed_orcids":["https://orcid.org/0000-0002-3138-0283"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael W. Crowder","raw_affiliation_strings":["Department of Chemistry, Miami University, Oxford, OH 45056, USA. crowdemw@muohio.edu","Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Miami University, Oxford, OH 45056, USA. crowdemw@muohio.edu","institution_ids":["https://openalex.org/I83328450"]},{"raw_affiliation_string":"Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031883283","display_name":"Mrinal Kumar Maiti","orcid":"https://orcid.org/0000-0001-7803-4356","observed_orcids":["https://orcid.org/0000-0001-7803-4356"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinal K. Maiti","raw_affiliation_strings":["Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066982612","display_name":"Linda Banovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Banovic","raw_affiliation_strings":["Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013459145","display_name":"Christopher A. Makaroff","orcid":"https://orcid.org/0000-0001-6237-1868","observed_orcids":["https://orcid.org/0000-0001-6237-1868"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Makaroff","raw_affiliation_strings":["Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Miami University, Hughes Hall, Oxford, OH 45056, USA","institution_ids":["https://openalex.org/I83328450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007268290"],"corresponding_institution_ids":["https://openalex.org/I83328450"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.8124,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.83864441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"418","issue":"3","first_page":"351","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyoxalase-ii","display_name":"glyoxalase II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9819999933242798},{"id":"https://openalex.org/keywords/zinc-binding","display_name":"zinc binding","score":0.6520000100135803},{"id":"https://openalex.org/keywords/metalloenzymes","display_name":"metalloenzymes","score":0.8059999942779541},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/metallo-beta-lactamase","display_name":"metallo-beta-lactamase","score":0.7929999828338623},{"id":"https://openalex.org/keywords/active-site","display_name":"active site","score":0.6439999938011169},{"id":"https://openalex.org/keywords/steady-state-kinetics","display_name":"steady-state kinetics","score":0.7319999933242798},{"id":"https://openalex.org/keywords/metal-ligands","display_name":"metal-binding ligands","score":0.47099998593330383},{"id":"https://openalex.org/keywords/cytoplasmic-enzymes","display_name":"cytosolic enzyme","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5803682804107666},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.5777047872543335},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.44092458486557007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38805487751960754},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099301","descriptor_name":"Hydroxyacylglutathione Hydrolase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013869","descriptor_name":"Thiolester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-5793(97)01416-6","doi":"https://doi.org/10.1016/s0014-5793(97)01416-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(97)01416-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2897%2901416-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:9428743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9428743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0014-5793(97)01416-6","doi":"https://doi.org/10.1016/s0014-5793(97)01416-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(97)01416-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2897%2901416-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2045160511","display_name":"Analysis of PHD-Domain Proteins Required For Meiosis","funder_award_id":"R15GM055956","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320308281","display_name":"Ohio Board of Regents","ror":"https://ror.org/00gj19047"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983108555.pdf","grobid_xml":"https://content.openalex.org/works/W1983108555.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W122218891","https://openalex.org/W1966901268","https://openalex.org/W1973924126","https://openalex.org/W1984929731","https://openalex.org/W2008158473","https://openalex.org/W2025451937","https://openalex.org/W2039149291","https://openalex.org/W2043338527","https://openalex.org/W2047546483","https://openalex.org/W2049291048","https://openalex.org/W2059039419","https://openalex.org/W2065668262","https://openalex.org/W2069986170","https://openalex.org/W2090133370","https://openalex.org/W2255950054","https://openalex.org/W2306899242","https://openalex.org/W2307065019","https://openalex.org/W2335801798","https://openalex.org/W2337672766","https://openalex.org/W2343847164","https://openalex.org/W2397884896","https://openalex.org/W2401061572","https://openalex.org/W2402553165","https://openalex.org/W2416627708","https://openalex.org/W2461924970","https://openalex.org/W4234084664"],"related_works":["https://openalex.org/W2597879927","https://openalex.org/W2034819233","https://openalex.org/W2088066159","https://openalex.org/W1966265281","https://openalex.org/W2164645645","https://openalex.org/W2028100835","https://openalex.org/W2076806894","https://openalex.org/W2071244442","https://openalex.org/W2003238390","https://openalex.org/W2154600206"],"abstract_inverted_index":{"Cytosolic":[0],"glyoxalase":[1,84,108,114,133,141],"II":[2,85,109,115,142],"from":[3,87],"Arabidopsis":[4],"thaliana,":[5,90],"GLX2-2,":[6],"was":[7],"overexpressed":[8],"and":[9,43,79,91,93,122,135],"purified":[10,33],"to":[11],"homogeneity":[12],"using":[13],"Q-sepharose":[14],"chromatography.":[15],"MALDI-TOF":[16],"mass":[17],"spectrometry":[18],"studies":[19,131],"indicated":[20],"a":[21,36,44],"molecular":[22],"weight":[23],"of":[24,38,46,66,72,83,102,129],"28":[25],"767":[26],"Da.":[27],"Using":[28],"steady-state":[29],"kinetics":[30],"studies,":[31],"the":[32,59,70,94,103,140],"enzyme":[34,60,77],"exhibited":[35],"Km":[37],"660":[39],"+/-":[40,48,63],"100":[41],"microM":[42],"kcat":[45],"484":[47],"92":[49],"s(-1)":[50],"at":[51],"37":[52],"degrees":[53],"C.":[54],"Metal":[55],"analyses":[56],"demonstrated":[57],"that":[58,97,112],"binds":[61],"2.1":[62],"0.5":[64],"moles":[65],"Zn(II)":[67,73,118],"per":[68],"monomer;":[69],"binding":[71,100],"is":[74,144],"essential":[75],"for":[76,139],"viability":[78],"activity.":[80],"Sequence":[81],"comparison":[82],"enzymes":[86,116,143],"human,":[88],"A.":[89],"yeast":[92],"metallo-beta-lactamases":[95,104],"reveal":[96],"all":[98,113],"metal":[99],"ligands":[101],"are":[105,117,125],"conserved":[106],"in":[107,127],"enzymes,":[110],"suggesting":[111],"metalloenzymes.":[119],"These":[120],"results":[121],"their":[123],"implications":[124],"discussed":[126],"light":[128],"previous":[130],"on":[132],"II,":[134],"an":[136],"active":[137],"site":[138],"proposed.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
