{"id":"https://openalex.org/W1983092829","doi":"https://doi.org/10.1016/j.cccn.2005.03.049","title":"Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition","display_name":"Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition","publication_year":2005,"publication_date":"2005-06-03","ids":{"openalex":"https://openalex.org/W1983092829","doi":"https://doi.org/10.1016/j.cccn.2005.03.049","mag":"1983092829","pmid":"https://pubmed.ncbi.nlm.nih.gov/15935339"},"language":"en","primary_location":{"id":"doi:10.1016/j.cccn.2005.03.049","doi":"https://doi.org/10.1016/j.cccn.2005.03.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cccn.2005.03.049","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103965228","display_name":"Ra\u00fal Omar Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ra\u00fal O. Dom\u00ednguez","raw_affiliation_strings":["Facultad de Medicina, Hospital Sirio-Liban\u00e9s-UBA, FACENE, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina, Hospital Sirio-Liban\u00e9s-UBA, FACENE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105466514","display_name":"Enrique R. Marschoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Enrique R. Marschoff","raw_affiliation_strings":["Facultad de Ciencias Exactas y Naturales, UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Exactas y Naturales, UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057014066","display_name":"Eduardo M. Guareschi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo M. Guareschi","raw_affiliation_strings":["Laboratorio Especializado para las Investigaciones, Cl\u00ednicas (LEPLIC), Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Especializado para las Investigaciones, Cl\u00ednicas (LEPLIC), Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088005291","display_name":"Arturo L. Famulari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Arturo L. Famulari","raw_affiliation_strings":["Facultad de Medicina, Hospital Sirio-Liban\u00e9s-UBA, FACENE, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina, Hospital Sirio-Liban\u00e9s-UBA, FACENE, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103956120","display_name":"Miguel Angel Pagano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210096133","display_name":"Hospital Fern\u00e1ndez","ror":"https://ror.org/00tdzhd41","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210096133"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Miguel A. Pagano","raw_affiliation_strings":["Facultad de Medicina, Hospital Juan A. Fern\u00e1ndez, UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina, Hospital Juan A. Fern\u00e1ndez, UBA, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210096133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087876045","display_name":"Jorge A. Serra","orcid":"https://orcid.org/0000-0002-0368-7640","observed_orcids":["https://orcid.org/0000-0002-0368-7640"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Jorge A. Serra","raw_affiliation_strings":["Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)-PRALIB, Facultad de Farmacia y Bioqu\u00edmica, UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)-PRALIB, Facultad de Farmacia y Bioqu\u00edmica, UBA, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087876045"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":1.0704,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75892916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"359","issue":"1-2","first_page":"163","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.9800000190734863},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/risk-factors-for-dementia","display_name":"dementia risk factors","score":0.5730000138282776},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.6069999933242798},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7934043407440186},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.7651826739311218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7540783882141113},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6151865124702454},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.5540449619293213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5516428351402283},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5457595586776733},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5146785378456116},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.501816987991333},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.48107290267944336},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.4519226551055908},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4209277927875519},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15459460020065308}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cccn.2005.03.049","doi":"https://doi.org/10.1016/j.cccn.2005.03.049","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cccn.2005.03.049","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:15935339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15935339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320333618","display_name":"Abbott Diagnostics","ror":null},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W609049029","https://openalex.org/W1792012223","https://openalex.org/W1858259598","https://openalex.org/W1937693126","https://openalex.org/W1960505070","https://openalex.org/W1985999186","https://openalex.org/W2001311361","https://openalex.org/W2016809841","https://openalex.org/W2019523275","https://openalex.org/W2025774809","https://openalex.org/W2038456752","https://openalex.org/W2043134943","https://openalex.org/W2052588755","https://openalex.org/W2054508440","https://openalex.org/W2061402259","https://openalex.org/W2075416870","https://openalex.org/W2079217524","https://openalex.org/W2093100094","https://openalex.org/W2102493638","https://openalex.org/W2112150247","https://openalex.org/W2114613490","https://openalex.org/W2116950438","https://openalex.org/W2118576335","https://openalex.org/W2136250824","https://openalex.org/W2142207144","https://openalex.org/W2146648547","https://openalex.org/W2153875735","https://openalex.org/W2156220037","https://openalex.org/W2159495338","https://openalex.org/W2334048454","https://openalex.org/W2345903479","https://openalex.org/W3022868799","https://openalex.org/W4241388204"],"related_works":["https://openalex.org/W2108167362","https://openalex.org/W2029470970","https://openalex.org/W2099614709","https://openalex.org/W4244812838","https://openalex.org/W2384200734","https://openalex.org/W2370256652","https://openalex.org/W2150509537","https://openalex.org/W2103535459","https://openalex.org/W2082413002","https://openalex.org/W2057394773"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}