{"id":"https://openalex.org/W1983015752","doi":"https://doi.org/10.1371/journal.pone.0011712","title":"Clinically Relevant Characterization of Lung Adenocarcinoma Subtypes Based on Cellular Pathways: An International Validation Study","display_name":"Clinically Relevant Characterization of Lung Adenocarcinoma Subtypes Based on Cellular Pathways: An International Validation Study","publication_year":2010,"publication_date":"2010-07-22","ids":{"openalex":"https://openalex.org/W1983015752","doi":"https://doi.org/10.1371/journal.pone.0011712","mag":"1983015752","pmid":"https://pubmed.ncbi.nlm.nih.gov/20661423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908611"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0011712","doi":"https://doi.org/10.1371/journal.pone.0011712","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011712","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011712&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011712&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079049023","display_name":"Christopher M. Bryant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Bryant","raw_affiliation_strings":["Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082978446","display_name":"Daniel L. Albertus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. Albertus","raw_affiliation_strings":["Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103224796","display_name":"Sinae Kim","orcid":"https://orcid.org/0000-0002-9900-492X","observed_orcids":["https://orcid.org/0000-0002-9900-492X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sinae Kim","raw_affiliation_strings":["Department of Biostatistics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001276721","display_name":"Guoan Chen","orcid":"https://orcid.org/0000-0001-5608-6761","observed_orcids":["https://orcid.org/0000-0001-5608-6761"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoan Chen","raw_affiliation_strings":["Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084934419","display_name":"Christian Brambilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christian Brambilla","raw_affiliation_strings":["Ligue Nationale Contre le Cancer, Programme Cartes d'Identit\u00e9 des Tumeurs, Universit\u00e9 Joseph Fourier, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ligue Nationale Contre le Cancer, Programme Cartes d'Identit\u00e9 des Tumeurs, Universit\u00e9 Joseph Fourier, Grenoble, France","institution_ids":["https://openalex.org/I177483745","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075313108","display_name":"Micka\u00ebl Guedj","orcid":"https://orcid.org/0000-0002-9742-957X","observed_orcids":["https://orcid.org/0000-0002-9742-957X"]},"institutions":[{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mickael Guedj","raw_affiliation_strings":["Ligue Nationale Contre le Cancer, Programme Cartes d'Identit\u00e9 des Tumeurs, Universit\u00e9 Joseph Fourier, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ligue Nationale Contre le Cancer, Programme Cartes d'Identit\u00e9 des Tumeurs, Universit\u00e9 Joseph Fourier, Grenoble, France","institution_ids":["https://openalex.org/I177483745","https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046868090","display_name":"Chinatsu Arima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chinatsu Arima","raw_affiliation_strings":["Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044483075","display_name":"William David Travis","orcid":"https://orcid.org/0000-0003-3160-6729","observed_orcids":["https://orcid.org/0000-0003-3160-6729"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Travis","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065196329","display_name":"Yasushi Yatabe","orcid":"https://orcid.org/0000-0003-1788-559X","observed_orcids":["https://orcid.org/0000-0003-1788-559X"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286927","display_name":"Aichi Cancer Center Hospital","ror":"https://ror.org/03kh0z432","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Yatabe","raw_affiliation_strings":["Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090236371","display_name":"Takashi Takahashi","orcid":"https://orcid.org/0000-0003-0615-7001","observed_orcids":["https://orcid.org/0000-0003-0615-7001"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takahashi","raw_affiliation_strings":["Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023993622","display_name":"Elisabeth M. Brambilla","orcid":"https://orcid.org/0000-0001-7559-2141","observed_orcids":["https://orcid.org/0000-0001-7559-2141"]},"institutions":[{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabeth Brambilla","raw_affiliation_strings":["D\u00e9partement d'Anatomie et Cytologie Pathologiques, Universit\u00e9 Joseph Fourier, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'Anatomie et Cytologie Pathologiques, Universit\u00e9 Joseph Fourier, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057943415","display_name":"David G. Beer","orcid":"https://orcid.org/0000-0002-2662-9507","observed_orcids":["https://orcid.org/0000-0002-2662-9507"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David G. Beer","raw_affiliation_strings":["Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5057943415"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I4390039285"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.7172,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95739638,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"5","issue":"7","first_page":"e11712","last_page":"e11712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.1746000051498413,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.12240000069141388,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cell-proliferation-pathways","display_name":"cell proliferation pathways","score":0.6570000052452087},{"id":"https://openalex.org/keywords/solid-component","display_name":"solid component","score":0.5210000276565552},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cancer-pathways","display_name":"cancer pathways","score":0.7020000219345093},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.628000020980835},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/targeted-therapy-sensitivity","display_name":"targeted therapy sensitivity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/international-validation","display_name":"international validation","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7411938905715942},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6867901086807251},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5549396872520447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4982337951660156},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45822063088417053},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4495030641555786},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4429767429828644},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4042072296142578},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38778454065322876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3711591064929962},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3679795265197754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3602288067340851},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33887726068496704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3198661804199219},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17715764045715332}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0011712","doi":"https://doi.org/10.1371/journal.pone.0011712","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011712","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011712&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2908611","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2908611","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20661423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20661423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.353.7328","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.353.7328","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c8/7b/PLoS_One_2010_Jul_22_5(7)_e11712.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ba78ce948c7a4f06b2e20da12c7ea872","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba78ce948c7a4f06b2e20da12c7ea872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 7, p e11712 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/142564","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Clinically_Relevant_Characterization_of_Lung_Adenocarcinoma_Subtypes_Based_on_Cellular_Pathways_An_International_Validation_Study/142564","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0011712","doi":"https://doi.org/10.1371/journal.pone.0011712","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0011712","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0011712&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","score":0.6899999976158142,"display_name":"No poverty"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2335950590","display_name":"MRM\u30fbMS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics","funder_award_id":"21249037","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983015752.pdf","grobid_xml":"https://content.openalex.org/works/W1983015752.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1988078905","https://openalex.org/W2000771269","https://openalex.org/W2017214085","https://openalex.org/W2025383700","https://openalex.org/W2036287744","https://openalex.org/W2073759231","https://openalex.org/W2076734146","https://openalex.org/W2095635764","https://openalex.org/W2104224322","https://openalex.org/W2125080028","https://openalex.org/W2132165198","https://openalex.org/W2150926065","https://openalex.org/W2158180864","https://openalex.org/W2163798887"],"related_works":["https://openalex.org/W4281638278","https://openalex.org/W4388525527","https://openalex.org/W1988078905","https://openalex.org/W2921528821","https://openalex.org/W4414129760","https://openalex.org/W4312388136","https://openalex.org/W4200379385","https://openalex.org/W7160303427","https://openalex.org/W4205115378","https://openalex.org/W2767345575"],"abstract_inverted_index":{"Lung":[0],"adenocarcinoma":[1],"(AD)":[2],"represents":[3],"a":[4,104,115,121,140,145],"predominant":[5],"type":[6],"of":[7,27,50,120,156],"lung":[8],"cancer":[9],"demonstrating":[10],"significant":[11],"morphologic":[12],"and":[13,31,39,45,52,80,129,169],"molecular":[14],"heterogeneity.":[15],"We":[16,151],"sought":[17],"to":[18,101,110,113,125,138,143,148],"understand":[19],"this":[20],"heterogeneity":[21],"by":[22],"utilizing":[23],"gene":[24,53],"expression":[25,54],"analyses":[26],"432":[28],"AD":[29,41,51,71,84,162],"samples":[30],"examining":[32],"associations":[33],"between":[34],"27":[35],"known":[36],"cancer-related":[37],"pathways":[38],"the":[40,62,111,130,136,154,175],"subtype,":[42],"clinical":[43],"characteristics":[44],"patient":[46],"survival.":[47],"Unsupervised":[48],"clustering":[49],"enrichment":[55],"analysis":[56],"reveals":[57],"that":[58,90],"cell":[59,74],"proliferation":[60,75],"is":[61],"most":[63],"important":[64],"pathway":[65],"separating":[66],"tumors":[67,91,102],"into":[68],"subgroups.":[69],"Further,":[70],"with":[72,92],"increased":[73,82],"demonstrate":[76],"significantly":[77],"poorer":[78],"outcome":[79],"an":[81],"solid":[83,94,105],"subtype":[85],"component.":[86,106],"Additionally,":[87],"we":[88],"find":[89],"any":[93],"component":[95],"have":[96],"decreased":[97],"survival":[98],"as":[99],"compared":[100],"without":[103],"These":[107],"results":[108,134],"lead":[109],"potential":[112],"use":[114,139],"relatively":[116],"simple":[117],"pathological":[118],"examination":[119],"tumor":[122],"in":[123],"order":[124],"determine":[126,144],"its":[127],"aggressiveness":[128],"patient's":[131,146],"prognosis.":[132],"Additional":[133],"suggest":[135],"ability":[137],"similar":[141],"approach":[142],"sensitivity":[147],"targeted":[149],"treatment.":[150],"then":[152],"demonstrated":[153],"consistency":[155],"these":[157],"findings":[158],"using":[159,174],"two":[160],"independent":[161],"cohorts":[163],"from":[164],"Asia":[165],"(N":[166,171],"=":[167,172],"87)":[168],"Europe":[170],"89)":[173],"identical":[176],"analytic":[177],"procedures.":[178]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
