{"id":"https://openalex.org/W1983012121","doi":"https://doi.org/10.1021/ac052020v","title":"High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry Analyzers","display_name":"High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry Analyzers","publication_year":2006,"publication_date":"2006-05-06","ids":{"openalex":"https://openalex.org/W1983012121","doi":"https://doi.org/10.1021/ac052020v","mag":"1983012121","pmid":"https://pubmed.ncbi.nlm.nih.gov/16737227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1785295"},"language":"en","primary_location":{"id":"doi:10.1021/ac052020v","doi":"https://doi.org/10.1021/ac052020v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac052020v","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1785295","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029979758","display_name":"Alexandre A. Shvartsburg","orcid":"https://orcid.org/0000-0003-4004-481X","observed_orcids":["https://orcid.org/0000-0003-4004-481X"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre A. Shvartsburg","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352","Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011089626","display_name":"Fumin Li","orcid":"https://orcid.org/0000-0002-3388-8929","observed_orcids":["https://orcid.org/0000-0002-3388-8929"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fumin Li","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027769343","display_name":"Keqi Tang","orcid":"https://orcid.org/0000-0003-0316-6850","observed_orcids":["https://orcid.org/0000-0003-0316-6850"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keqi Tang","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023982706","display_name":"Richard D. Smith","orcid":"https://orcid.org/0000-0002-2381-2349","observed_orcids":["https://orcid.org/0000-0002-2381-2349"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Smith","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, MS K8-98, 3335 Q Avenue, Richland, Washington 99352","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.888,"has_fulltext":false,"cited_by_count":193,"citation_normalized_percentile":{"value":0.94865575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"78","issue":"11","first_page":"3706","last_page":"3714"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resolving-power","display_name":"resolving power","score":0.7250000238418579},{"id":"https://openalex.org/keywords/ion-mobility","display_name":"ion mobility","score":0.5049999952316284},{"id":"https://openalex.org/keywords/protonated-amino-acids","display_name":"protonated amino acids","score":0.7210000157356262},{"id":"https://openalex.org/keywords/protein-conformers","display_name":"protein conformers","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9148877859115601},{"id":"https://openalex.org/C15213710","wikidata":"https://www.wikidata.org/wiki/Q904207","display_name":"Ion-mobility spectrometry","level":3,"score":0.9131091833114624},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.665303111076355},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.5734339356422424},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5725029110908508},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.49368223547935486},{"id":"https://openalex.org/C134786449","wikidata":"https://www.wikidata.org/wiki/Q3391255","display_name":"Planar","level":2,"score":0.489581435918808},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2927303612232208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ac052020v","doi":"https://doi.org/10.1021/ac052020v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac052020v","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:16737227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16737227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1785295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1785295","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1785295","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1785295","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3875803176","display_name":"A Proteomics Research Resource for Integrative Biology","funder_award_id":"P41RR018522","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338354","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1597678601","https://openalex.org/W1963780497","https://openalex.org/W1965678263","https://openalex.org/W1968518360","https://openalex.org/W1969416735","https://openalex.org/W1970696723","https://openalex.org/W1972198759","https://openalex.org/W1974263191","https://openalex.org/W1975022146","https://openalex.org/W1977690909","https://openalex.org/W1980868151","https://openalex.org/W1985854842","https://openalex.org/W1986249771","https://openalex.org/W1987363356","https://openalex.org/W1988008969","https://openalex.org/W1993443994","https://openalex.org/W1998161543","https://openalex.org/W2000021673","https://openalex.org/W2002072789","https://openalex.org/W2003250682","https://openalex.org/W2004856704","https://openalex.org/W2007216521","https://openalex.org/W2007220030","https://openalex.org/W2008021715","https://openalex.org/W2011145336","https://openalex.org/W2013313370","https://openalex.org/W2016360410","https://openalex.org/W2023096047","https://openalex.org/W2024072498","https://openalex.org/W2025034281","https://openalex.org/W2025045144","https://openalex.org/W2032322811","https://openalex.org/W2038790579","https://openalex.org/W2044031477","https://openalex.org/W2044466034","https://openalex.org/W2044970750","https://openalex.org/W2047374213","https://openalex.org/W2048933572","https://openalex.org/W2050668513","https://openalex.org/W2051185298","https://openalex.org/W2051332673","https://openalex.org/W2052271448","https://openalex.org/W2056544504","https://openalex.org/W2058476226","https://openalex.org/W2059438574","https://openalex.org/W2060805965","https://openalex.org/W2061802503","https://openalex.org/W2062727375","https://openalex.org/W2065482248","https://openalex.org/W2066424400","https://openalex.org/W2076376894","https://openalex.org/W2078594804","https://openalex.org/W2079115619","https://openalex.org/W2081651427","https://openalex.org/W2082333780","https://openalex.org/W2085730038","https://openalex.org/W2086616699","https://openalex.org/W2089009468","https://openalex.org/W2091571161","https://openalex.org/W2091795411","https://openalex.org/W2092983480","https://openalex.org/W2097229040","https://openalex.org/W2102985062","https://openalex.org/W2125394339","https://openalex.org/W2135757571","https://openalex.org/W2136960621","https://openalex.org/W2149558839","https://openalex.org/W2151481337","https://openalex.org/W2167714733","https://openalex.org/W2172024272","https://openalex.org/W4244582831","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2051332673","https://openalex.org/W2101216641","https://openalex.org/W2159811810","https://openalex.org/W4398199280","https://openalex.org/W2347992072","https://openalex.org/W2065327542","https://openalex.org/W2286112380","https://openalex.org/W4393102091","https://openalex.org/W2164840971","https://openalex.org/W2065482248"],"abstract_inverted_index":{"Field":[0],"asymmetric":[1],"waveform":[2],"ion":[3,126,149,158],"mobility":[4,39],"spectrometry":[5,28],"(FAIMS)":[6],"has":[7],"emerged":[8],"as":[9],"a":[10,91,119,134,139,162],"powerful":[11],"tool":[12],"of":[13,20,38,56,70,73,80,111,115,121,187,216],"broad":[14],"utility":[15],"for":[16,143,206],"separation":[17,186],"and":[18,128,151,198],"characterization":[19],"gas-phase":[21],"ions,":[22],"especially":[23],"in":[24,88,191],"conjunction":[25],"with":[26,146,161],"mass":[27],"(MS).":[29],"In":[30,106],"FAIMS,":[31],"ions":[32],"are":[33],"filtered":[34],"by":[35,46,118],"the":[36,50,78,81,97,108,125,177],"dependence":[37],"on":[40,124],"electric":[41],"field":[42],"while":[43],"being":[44],"carried":[45],"gas":[47],"flow":[48],"through":[49],"analytical":[51],"gap":[52],"between":[53],"two":[54,82],"electrodes":[55],"either":[57],"planar":[58,136],"(p-)":[59],"or":[60,200],"cylindrical":[61],"(c-)":[62],"geometry.":[63],"Most":[64],"FAIMS/MS":[65],"systems":[66],"employ":[67],"c-FAIMS":[68],"because":[69,215],"its":[71],"ease":[72],"coupling":[74],"to":[75,153,170],"MS,":[76],"yet":[77],"merits":[79],"geometries":[83],"have":[84,132],"not":[85,189],"been":[86],"compared":[87],"detail.":[89],"Here,":[90],"priori":[92],"simulations":[93],"reveal":[94],"that":[95,114],"reducing":[96],"FAIMS":[98,137,193],"curvature":[99],"always":[100],"improves":[101],"resolution":[102,167],"at":[103],"equal":[104],"sensitivity.":[105],"particular,":[107],"resolving":[109],"power":[110],"p-FAIMS":[112],"exceeds":[113],"c-FAIMS,":[116,174],"typically":[117],"factor":[120],"2-4":[122],"depending":[123],"species":[127,188],"carrier":[129],"gas.":[130],"We":[131],"constructed":[133],"new":[135,201],"incorporating":[138],"curtain":[140],"plate":[141],"interface":[142,160],"effective":[144],"operation":[145],"an":[147,154,157],"ESI":[148],"source":[150],"joined":[152],"MS":[155],"using":[156],"funnel":[159],"novel":[163],"slit":[164],"aperture.":[165],"The":[166,204],"increases":[168],"up":[169],"4-fold":[171],"over":[172],"existing":[173],"even":[175],"though":[176],"analysis":[178],"is":[179,211],"approximately":[180],"2":[181],"times":[182],"faster.":[183],"This":[184],"allows":[185],"feasible":[190],"previous":[192],"studies,":[194],"e.g.,":[195],"protonated":[196],"leucine":[197],"isoleucine":[199],"bradykinin":[202],"isomers.":[203],"improvement":[205],"protein":[207],"conformers":[208],"(of":[209],"ubiquitin)":[210],"less":[212],"significant,":[213],"possibly":[214],"multiple":[217],"unresolved":[218],"geometries.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}