{"id":"https://openalex.org/W1983003192","doi":"https://doi.org/10.1073/pnas.97.17.9759","title":"Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse","display_name":"Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse","publication_year":2000,"publication_date":"2000-08-15","ids":{"openalex":"https://openalex.org/W1983003192","doi":"https://doi.org/10.1073/pnas.97.17.9759","mag":"1983003192","pmid":"https://pubmed.ncbi.nlm.nih.gov/10944235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/16938"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.97.17.9759","doi":"https://doi.org/10.1073/pnas.97.17.9759","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.17.9759","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067574356","display_name":"Jeff Reese","orcid":"https://orcid.org/0000-0001-8751-6146","observed_orcids":["https://orcid.org/0000-0001-8751-6146"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Reese","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071299965","display_name":"Bibhash C. Paria","orcid":"https://orcid.org/0000-0002-1183-8648","observed_orcids":["https://orcid.org/0000-0002-1183-8648"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibhash C. Paria","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109279989","display_name":"Naoko Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoko Brown","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuemei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuemei Zhao","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","University of Missouri, Columbia, MO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I901861585"]},{"raw_affiliation_string":"University of Missouri, Columbia, MO,","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044445154","display_name":"Jason D. Morrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Morrow","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073799238","display_name":"Sudhansu K. Dey","orcid":"https://orcid.org/0000-0001-9159-186X","observed_orcids":["https://orcid.org/0000-0001-9159-186X"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhansu K. Dey","raw_affiliation_strings":["Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","University of Missouri, Columbia, MO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160-7338; and Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6602","institution_ids":["https://openalex.org/I4210128618","https://openalex.org/I901861585"]},{"raw_affiliation_string":"University of Missouri, Columbia, MO,","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8733,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95251234,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"97","issue":"17","first_page":"9759","last_page":"9764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.5249000191688538,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12272","display_name":"Cardiovascular Conditions and Treatments","score":0.24050000309944153,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/childbirth","display_name":"childbirth","score":0.9750000238418579},{"id":"https://openalex.org/keywords/uterine-epithelium","display_name":"uterine epithelium","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ductus-arteriosus-patency","display_name":"ductus arteriosus patency","score":0.9229999780654907},{"id":"https://openalex.org/keywords/maternal-fetal-interaction","display_name":"maternal-fetal interaction","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.4259999990463257},{"id":"https://openalex.org/keywords/postnatal-adaptation","display_name":"postnatal adaptation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/preterm-labor","display_name":"preterm labor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostaglandin-receptors","display_name":"prostaglandin receptors","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.826592206954956},{"id":"https://openalex.org/C2781236024","wikidata":"https://www.wikidata.org/wiki/Q1163923","display_name":"Ductus arteriosus","level":2,"score":0.6911536455154419},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6044362783432007},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.5607156753540039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5076714754104614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.502919614315033},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5002775192260742},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.49103808403015137},{"id":"https://openalex.org/C2779753670","wikidata":"https://www.wikidata.org/wiki/Q2657962","display_name":"Fetal circulation","level":5,"score":0.45522746443748474},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4320957064628601},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4205370843410492},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3759756088256836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32497158646583557},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.2512931823730469},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12359309196472168},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09479963779449463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004374","descriptor_name":"Ductus Arteriosus, Patent","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004374","descriptor_name":"Ductus Arteriosus, Patent","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004374","descriptor_name":"Ductus Arteriosus, Patent","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.97.17.9759","doi":"https://doi.org/10.1073/pnas.97.17.9759","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.17.9759","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1234722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:16938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10944235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10944235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"mag:3152312158","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/80012131772","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci USA","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1234722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2440397094","display_name":"Research Center for Pharmacology and Drug Toxicology","funder_award_id":"P50GM015431","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G387269973","display_name":"SUSTAINED DEVELOPMENT OF CLINICIAN RESEARCHERS","funder_award_id":"P20RR011825","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4052891390","display_name":"ASPECTS OF BLASTOCYST IMPLANTATION","funder_award_id":"R37HD012304","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4455488328","display_name":"Research Center for Pharmacology & Drug Toxicology","funder_award_id":"P01GM015431","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4911894574","display_name":"NEUREGULIN-MEDIATED CELL SIGNALING DURING IMPLANTATION","funder_award_id":"R03HD037677","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G510208870","display_name":null,"funder_award_id":"HD 02528","funder_id":"https://openalex.org/F4320337364","funder_display_name":"National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7452238844","display_name":"Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC)","funder_award_id":"P30HD002528","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8255882378","display_name":"Biochemistry and Pharmacology of D2/E2 Isoprostanes","funder_award_id":"R01DK048831","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000057978","display_name":null,"funder_award_id":"HD12304","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000076365","display_name":null,"funder_award_id":"HD02528","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000137775","display_name":null,"funder_award_id":"GM 15431","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W136243719","https://openalex.org/W163151552","https://openalex.org/W1666619344","https://openalex.org/W1978314017","https://openalex.org/W1981292116","https://openalex.org/W1985844039","https://openalex.org/W1987530541","https://openalex.org/W1990030459","https://openalex.org/W2001782282","https://openalex.org/W2002312231","https://openalex.org/W2003594973","https://openalex.org/W2011071587","https://openalex.org/W2014420864","https://openalex.org/W2014553384","https://openalex.org/W2017674756","https://openalex.org/W2020049673","https://openalex.org/W2020341395","https://openalex.org/W2021030634","https://openalex.org/W2023507758","https://openalex.org/W2024408058","https://openalex.org/W2032720625","https://openalex.org/W2035810647","https://openalex.org/W2040040765","https://openalex.org/W2047137383","https://openalex.org/W2065246734","https://openalex.org/W2068900843","https://openalex.org/W2069381296","https://openalex.org/W2077608143","https://openalex.org/W2085052924","https://openalex.org/W2099443926","https://openalex.org/W2102368544","https://openalex.org/W2104130176","https://openalex.org/W2107833029","https://openalex.org/W2117598587","https://openalex.org/W2124302318","https://openalex.org/W2145205612","https://openalex.org/W2153643012","https://openalex.org/W2160630886","https://openalex.org/W2161935332","https://openalex.org/W2169279216","https://openalex.org/W2313220264","https://openalex.org/W2403572081","https://openalex.org/W2405821925","https://openalex.org/W2429747078","https://openalex.org/W2490372353","https://openalex.org/W2800526221","https://openalex.org/W2926273414"],"related_works":["https://openalex.org/W2077608143","https://openalex.org/W4239127512","https://openalex.org/W2014553384","https://openalex.org/W2759334075","https://openalex.org/W3152312158","https://openalex.org/W1991534857","https://openalex.org/W2129378740","https://openalex.org/W7097241138","https://openalex.org/W2003594973","https://openalex.org/W2973275707"],"abstract_inverted_index":{"Cyclooxygenase":[0],"(COX)-derived":[1],"prostaglandins":[2],"(PGs)":[3],"regulate":[4],"numerous":[5],"maternal-fetal":[6],"interactions":[7],"during":[8,93],"pregnancy.":[9],"PGs":[10,24,54,92,131,178,198],"stimulate":[11],"uterine":[12,85],"contractions":[13],"and":[14,48,95,155,196],"prepare":[15],"the":[16,22,28,41,46,84,88,127,137,150,185,191,200,208,215],"cervix":[17],"for":[18,132,214],"parturition,":[19],"whereas":[20],"in":[21,83,119,149],"fetus,":[23],"maintain":[25],"patency":[26,135,174],"of":[27,50,52,91,129,136,194,202,210,217],"ductus":[29],"arteriosus":[30],"(DA),":[31],"a":[32,74,158],"vascular":[33],"shunt":[34],"that":[35,81,96,102,115,172],"transmits":[36],"oxygenated":[37],"placental":[38],"blood":[39],"to":[40],"fetal":[42,130,151,195],"systemic":[43],"circulation.":[44],"However,":[45],"origin":[47],"site":[49],"action":[51],"these":[53,188],"remain":[55],"undefined.":[56],"To":[57],"address":[58],"this,":[59],"we":[60,112],"analyzed":[61],"mice":[62],"lacking":[63],"COX-1":[64,82,143],"(null":[65],"mutation)":[66],"or":[67,71,152],"COX-2":[68,145],"(pharmacologic":[69],"inhibition)":[70],"pups":[72],"with":[73,157,166],"double":[75,159],"null":[76,160],"mutation.":[77],"Our":[78],"results":[79,170],"show":[80,114],"epithelium":[86],"is":[87,103,139],"major":[89],"source":[90],"labor":[94],"COX-1(-/-)":[97,120],"females":[98],"experience":[99],"parturition":[100],"failure":[101],"reversible":[104],"by":[105],"exogenous":[106],"PGs.":[107],"Using":[108],"embryo":[109],"transfer":[110],"experiments,":[111],"also":[113],"successful":[116],"delivery":[117],"occurs":[118],"recipient":[121],"mothers":[122],"carrying":[123],"wild-type":[124],"pups,":[125],"establishing":[126],"sufficiency":[128],"parturition.":[133],"Although":[134],"DA":[138,173],"PG":[140,182],"dependent,":[141],"neither":[142],"nor":[144],"expression":[146],"was":[147],"detected":[148],"postnatal":[153],"DA,":[154],"offspring":[156],"mutation":[161],"died":[162],"shortly":[163],"after":[164],"birth":[165,203],"open":[167],"DAs.":[168],"These":[169],"suggest":[171],"depends":[175],"on":[176,180],"circulating":[177],"acting":[179],"specific":[181],"receptors":[183],"within":[184],"DA.":[186],"Collectively,":[187],"findings":[189],"demonstrate":[190],"coordinated":[192],"regulation":[193],"maternal":[197],"at":[199],"time":[201],"but":[204],"raise":[205],"concern":[206],"regarding":[207],"use":[209],"selective":[211],"COX":[212],"inhibitors":[213],"management":[216],"preterm":[218],"labor.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}