{"id":"https://openalex.org/W1982999222","doi":"https://doi.org/10.1172/jci78371","title":"Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight","display_name":"Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight","publication_year":2014,"publication_date":"2014-09-08","ids":{"openalex":"https://openalex.org/W1982999222","doi":"https://doi.org/10.1172/jci78371","mag":"1982999222","pmid":"https://pubmed.ncbi.nlm.nih.gov/25202976","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4191040"},"language":"en","primary_location":{"id":"doi:10.1172/jci78371","doi":"https://doi.org/10.1172/jci78371","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci78371","pdf_url":"http://www.jci.org/articles/view/78371/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/78371/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078676914","display_name":"Laurie L. Baggio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie L. Baggio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057472647","display_name":"Daniel J. Drucker","orcid":"https://orcid.org/0000-0001-6688-8127","observed_orcids":["https://orcid.org/0000-0001-6688-8127"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel J. Drucker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057472647"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":6.0491,"has_fulltext":true,"cited_by_count":262,"citation_normalized_percentile":{"value":0.9761952,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"124","issue":"10","first_page":"4223","last_page":"4226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9800000190734863},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.7250000238418579},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.9269999861717224},{"id":"https://openalex.org/keywords/body-weight-regulation","display_name":"body weight regulation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.8209999799728394},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8289999961853027},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9279999732971191},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5260000228881836},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.6990000009536743},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7383795380592346},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7340515851974487},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.7040234208106995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7033610939979553},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6153887510299683},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6132112145423889},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5750770568847656},{"id":"https://openalex.org/C185280430","wikidata":"https://www.wikidata.org/wiki/Q14909910","display_name":"Glucagon-like peptide 1 receptor","level":4,"score":0.5332180261611938},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.480092316865921},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47094571590423584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43711239099502563},{"id":"https://openalex.org/C3020479747","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Gastric emptying","level":3,"score":0.429138720035553},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42209935188293457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.401516854763031},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.30700305104255676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26513803005218506},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.24058708548545837},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1172/jci78371","doi":"https://doi.org/10.1172/jci78371","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci78371","pdf_url":"http://www.jci.org/articles/view/78371/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4191040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4191040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:25202976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25202976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci78371","doi":"https://doi.org/10.1172/jci78371","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci78371","pdf_url":"http://www.jci.org/articles/view/78371/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320334604","display_name":"Banting and Best Diabetes Centre, University of Toronto","ror":"https://ror.org/03dbr7087"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982999222.pdf","grobid_xml":"https://content.openalex.org/works/W1982999222.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1543470256","https://openalex.org/W1967442749","https://openalex.org/W1990192942","https://openalex.org/W2013082477","https://openalex.org/W2014156217","https://openalex.org/W2018940614","https://openalex.org/W2021673611","https://openalex.org/W2028637607","https://openalex.org/W2043889992","https://openalex.org/W2054981500","https://openalex.org/W2077449634","https://openalex.org/W2089592096","https://openalex.org/W2111482319","https://openalex.org/W2128825255","https://openalex.org/W2128939426","https://openalex.org/W2138077952","https://openalex.org/W2144288812","https://openalex.org/W2146849752","https://openalex.org/W2163229244","https://openalex.org/W2168899316"],"related_works":["https://openalex.org/W4404800980","https://openalex.org/W2017810555","https://openalex.org/W4409951953","https://openalex.org/W7133519366","https://openalex.org/W2168899316","https://openalex.org/W2014156217","https://openalex.org/W2803591279","https://openalex.org/W7124291437","https://openalex.org/W2330887677","https://openalex.org/W3211052978"],"abstract_inverted_index":{"The":[0],"peptide":[1,88],"hormone":[2],"glucagon-like":[3],"peptide-1":[4],"(GLP-1)":[5],"enhances":[6],"glucose-induced":[7],"insulin":[8],"secretion":[9],"and":[10,15,29,35,41,94],"inhibits":[11],"both":[12],"gastric":[13],"emptying":[14],"glucagon":[16],"secretion.":[17],"GLP-1":[18],"receptor":[19],"(GLP-1R)":[20],"agonists":[21],"control":[22,122],"glycemia":[23],"via":[24],"glucose-dependent":[25],"mechanisms":[26,40],"of":[27,98,123],"action":[28],"promote":[30],"weight":[31,46,73,107,125],"loss":[32,47,74],"in":[33,54,77,101,126],"obese":[34],"diabetic":[36],"individuals.":[37],"Nevertheless,":[38],"the":[39,45,55,60,78,92,102],"cellular":[42],"targets":[43],"transducing":[44],"effects":[48],"remain":[49],"unclear.":[50],"Two":[51],"recent":[52],"studies":[53,112],"JCI":[56],"provide":[57],"insight":[58],"into":[59],"neurons":[61,100],"responsible":[62],"for":[63],"this":[64],"effect.":[65],"Sisley":[66],"et":[67,82],"al.":[68,83],"reveal":[69,84],"that":[70,85,115],"GLP-1R":[71,89,119],"agonist-induced":[72],"requires":[75],"GLP-1Rs":[76],"CNS,":[79],"while":[80],"Secher":[81],"a":[86,96],"small":[87],"agonist":[90],"penetrates":[91],"brain":[93],"activates":[95],"subset":[97],"GLP-1R-expressing":[99],"arcuate":[103],"nucleus":[104],"to":[105,121],"produce":[106],"loss.":[108],"Together,":[109],"these":[110],"two":[111],"elucidate":[113],"pathways":[114],"inform":[116],"strategies":[117],"coupling":[118],"signaling":[120],"body":[124],"patients":[127],"with":[128],"diabetes":[129],"or":[130],"obesity.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":47},{"year":2025,"cited_by_count":50},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}