{"id":"https://openalex.org/W1982990246","doi":"https://doi.org/10.1016/j.tim.2005.02.004","title":"Hepatitis C virus, ER stress, and oxidative stress","display_name":"Hepatitis C virus, ER stress, and oxidative stress","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W1982990246","doi":"https://doi.org/10.1016/j.tim.2005.02.004","mag":"1982990246","pmid":"https://pubmed.ncbi.nlm.nih.gov/15817385"},"language":"en","primary_location":{"id":"doi:10.1016/j.tim.2005.02.004","doi":"https://doi.org/10.1016/j.tim.2005.02.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tim.2005.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S587692","display_name":"Trends in Microbiology","issn_l":"0966-842X","issn":["0966-842X","1878-4380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065412493","display_name":"Keith D. Tardif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith D. Tardif","raw_affiliation_strings":["Department of Microbiology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA","Present Address: Myriad Pharmaceuticals, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Present Address: Myriad Pharmaceuticals, Inc., 320 Wakara Way, Salt Lake City, UT 84108, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034822377","display_name":"Gulam Waris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gulam Waris","raw_affiliation_strings":["Department of Microbiology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005340343","display_name":"Aleem Siddiqui","orcid":"https://orcid.org/0000-0001-5970-7535","observed_orcids":["https://orcid.org/0000-0001-5970-7535"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aleem Siddiqui","raw_affiliation_strings":["Department of Microbiology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Program in Molecular Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005340343"],"corresponding_institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.2217,"has_fulltext":false,"cited_by_count":239,"citation_normalized_percentile":{"value":0.77171717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"13","issue":"4","first_page":"159","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/er-calcium-homeostasis","display_name":"ER calcium homeostasis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.8460000157356262},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6380000114440918},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.6190000176429749},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.75}],"concepts":[{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.9396778345108032},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.9220229387283325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6498939394950867},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5289300084114075},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5053315758705139},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5001869201660156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4567185640335083},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3870265483856201},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3773181438446045},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3619237542152405},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12439268827438354}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tim.2005.02.004","doi":"https://doi.org/10.1016/j.tim.2005.02.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tim.2005.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S587692","display_name":"Trends in Microbiology","issn_l":"0966-842X","issn":["0966-842X","1878-4380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Microbiology","raw_type":"journal-article"},{"id":"pmid:15817385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15817385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6800000071525574,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1867491726","display_name":null,"funder_award_id":"T3-DK07038","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6471001570","display_name":"Hepatitis C Virus NS5a Protein and Oxidative Stress","funder_award_id":"R01DK061566","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7226503062","display_name":"Gastrointestinal Diseases Training Grant","funder_award_id":"T32DK007038","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G786685984","display_name":null,"funder_award_id":"DK061566","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1219460262","https://openalex.org/W1546139069","https://openalex.org/W1836032532","https://openalex.org/W1914838920","https://openalex.org/W1968426124","https://openalex.org/W1970090817","https://openalex.org/W1986737010","https://openalex.org/W1986987167","https://openalex.org/W1988482079","https://openalex.org/W2008734149","https://openalex.org/W2009080092","https://openalex.org/W2010330364","https://openalex.org/W2017290665","https://openalex.org/W2020004919","https://openalex.org/W2024282024","https://openalex.org/W2027545702","https://openalex.org/W2029642537","https://openalex.org/W2038481055","https://openalex.org/W2059332843","https://openalex.org/W2059457521","https://openalex.org/W2062918974","https://openalex.org/W2069531923","https://openalex.org/W2071273959","https://openalex.org/W2080543752","https://openalex.org/W2082933842","https://openalex.org/W2094558573","https://openalex.org/W2104085655","https://openalex.org/W2106314483","https://openalex.org/W2109884870","https://openalex.org/W2112876622","https://openalex.org/W2120736516","https://openalex.org/W2125701478","https://openalex.org/W2127639686","https://openalex.org/W2127906377","https://openalex.org/W2132444008","https://openalex.org/W2133590872","https://openalex.org/W2137230586","https://openalex.org/W2140187466","https://openalex.org/W2160425277","https://openalex.org/W2161083011","https://openalex.org/W2163568031","https://openalex.org/W2169757199","https://openalex.org/W4238261567"],"related_works":["https://openalex.org/W1974968790","https://openalex.org/W2089077392","https://openalex.org/W6962521605","https://openalex.org/W2084564033","https://openalex.org/W7097004761","https://openalex.org/W2908300493","https://openalex.org/W2068367627","https://openalex.org/W2406786241","https://openalex.org/W3142891965","https://openalex.org/W4310215594"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":21}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
