{"id":"https://openalex.org/W1982988855","doi":"https://doi.org/10.3109/07435800.2014.895377","title":"3\u03b2HSD and CYB5A double positive adrenocortical cells during adrenal development/aging","display_name":"3\u03b2HSD and CYB5A double positive adrenocortical cells during adrenal development/aging","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W1982988855","doi":"https://doi.org/10.3109/07435800.2014.895377","mag":"1982988855","pmid":"https://pubmed.ncbi.nlm.nih.gov/24832628"},"language":"en","primary_location":{"id":"doi:10.3109/07435800.2014.895377","doi":"https://doi.org/10.3109/07435800.2014.895377","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07435800.2014.895377","pdf_url":null,"source":{"id":"https://openalex.org/S9543412","display_name":"Endocrine Research","issn_l":"0743-5800","issn":["0743-5800","1532-4206"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4242803","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045498023","display_name":"Yasuhiro Nakamura","orcid":"https://orcid.org/0000-0003-2167-9182","observed_orcids":["https://orcid.org/0000-0003-2167-9182"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuhiro Nakamura","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine , Sendai , Japan and","Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine , Sendai , Japan and","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035337577","display_name":"Fumiyoshi Fujishima","orcid":"https://orcid.org/0000-0001-8400-5551","observed_orcids":["https://orcid.org/0000-0001-8400-5551"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiyoshi Fujishima","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102083397","display_name":"Xiao-Gang Hui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xiao-Gang Hui","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030679758","display_name":"Saulo J.A. Felizola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saulo J. A. Felizola","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028637130","display_name":"Yukiko Shibahara","orcid":"https://orcid.org/0000-0001-5929-4670","observed_orcids":["https://orcid.org/0000-0001-5929-4670"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Shibahara","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057123160","display_name":"Jun\u2010ichi Akahira","orcid":"https://orcid.org/0000-0002-3486-5374","observed_orcids":["https://orcid.org/0000-0002-3486-5374"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Akahira","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078893804","display_name":"Keely May McNamara","orcid":"https://orcid.org/0000-0002-1982-5737","observed_orcids":["https://orcid.org/0000-0002-1982-5737"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keely M. McNamara","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085226848","display_name":"William E. Rainey","orcid":"https://orcid.org/0000-0001-5557-8406","observed_orcids":["https://orcid.org/0000-0001-5557-8406"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Rainey","raw_affiliation_strings":["Department of Physiology and Medicine, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Medicine, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015575554","display_name":"Hironobu Sasano","orcid":"https://orcid.org/0000-0002-6600-8641","observed_orcids":["https://orcid.org/0000-0002-6600-8641"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironobu Sasano","raw_affiliation_strings":["Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan and","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045498023"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":null,"apc_paid":null,"fwci":0.4786,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.6800055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"40","issue":"1","first_page":"8","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.053199999034404755,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3beta-hydroxysteroid-dehydrogenase","display_name":"3\u03b2-hydroxysteroid dehydrogenase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytochrome-b5","display_name":"cytochrome b5","score":0.9509999752044678},{"id":"https://openalex.org/keywords/androstenedione","display_name":"androstenedione","score":0.8299999833106995},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.7850000262260437},{"id":"https://openalex.org/keywords/zona-fasciculata","display_name":"zona fasciculata","score":0.8930000066757202},{"id":"https://openalex.org/keywords/zona-reticularis","display_name":"zona reticularis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adrenal-gland-development","display_name":"adrenal development","score":0.7390000224113464},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.734000027179718},{"id":"https://openalex.org/keywords/cyp17","display_name":"CYP17","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2777784954","wikidata":"https://www.wikidata.org/wiki/Q3549771","display_name":"Zona reticularis","level":5,"score":0.9264081716537476},{"id":"https://openalex.org/C2778736161","wikidata":"https://www.wikidata.org/wiki/Q3301573","display_name":"Zona fasciculata","level":3,"score":0.9100452661514282},{"id":"https://openalex.org/C2780178468","wikidata":"https://www.wikidata.org/wiki/Q3551060","display_name":"Zona glomerulosa","level":4,"score":0.8720972537994385},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.8536038398742676},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.8135726451873779},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6907848119735718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6772374510765076},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.6147685050964355},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4512074887752533},{"id":"https://openalex.org/C2780321258","wikidata":"https://www.wikidata.org/wiki/Q21110736","display_name":"21-Hydroxylase","level":3,"score":0.4483906626701355},{"id":"https://openalex.org/C155392382","wikidata":"https://www.wikidata.org/wiki/Q904925","display_name":"Steroid 11-beta-hydroxylase","level":4,"score":0.44266992807388306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44082915782928467},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3475412428379059},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.24601060152053833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19294920563697815},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.1276085078716278},{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.09264302253723145},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06970596313476562},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015067","descriptor_name":"17-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015067","descriptor_name":"17-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015067","descriptor_name":"17-Hydroxysteroid Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015786","descriptor_name":"Cytochromes b5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015786","descriptor_name":"Cytochromes b5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015786","descriptor_name":"Cytochromes b5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/07435800.2014.895377","doi":"https://doi.org/10.3109/07435800.2014.895377","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07435800.2014.895377","pdf_url":null,"source":{"id":"https://openalex.org/S9543412","display_name":"Endocrine Research","issn_l":"0743-5800","issn":["0743-5800","1532-4206"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Research","raw_type":"journal-article"},{"id":"pmid:24832628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24832628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4242803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4242803","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocr Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4242803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4242803","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocr Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5099999904632568}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4170207473","display_name":null,"funder_award_id":"DK069950","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6670969109","display_name":"Molecular Mechanisms of Adrenarche","funder_award_id":"R01DK069950","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W57983311","https://openalex.org/W1534713573","https://openalex.org/W1587076945","https://openalex.org/W1971769968","https://openalex.org/W1972918513","https://openalex.org/W1974686091","https://openalex.org/W1979060893","https://openalex.org/W1980553256","https://openalex.org/W1987417597","https://openalex.org/W1989300914","https://openalex.org/W1993992055","https://openalex.org/W2009110883","https://openalex.org/W2012856076","https://openalex.org/W2030809745","https://openalex.org/W2040341856","https://openalex.org/W2043040454","https://openalex.org/W2058350561","https://openalex.org/W2063095930","https://openalex.org/W2069043902","https://openalex.org/W2080498417","https://openalex.org/W2081975982","https://openalex.org/W2094544572","https://openalex.org/W2104720541","https://openalex.org/W2106559777","https://openalex.org/W2109280142","https://openalex.org/W2121590414","https://openalex.org/W2126406725","https://openalex.org/W2126733133","https://openalex.org/W2137714495","https://openalex.org/W2143399308","https://openalex.org/W2157586615","https://openalex.org/W2160644239","https://openalex.org/W2178183120"],"related_works":["https://openalex.org/W4245965665","https://openalex.org/W2152402859","https://openalex.org/W2415146231","https://openalex.org/W560993557","https://openalex.org/W2406922064","https://openalex.org/W2146284557","https://openalex.org/W3003577990","https://openalex.org/W162027227","https://openalex.org/W2769026301","https://openalex.org/W75534264"],"abstract_inverted_index":{"Androstenedione":[0],"is":[1,29],"a":[2],"common":[3],"precursor":[4],"of":[5,58,69,98,147,215,228],"sex":[6],"steroids":[7],"produced":[8,17],"and":[9,16,24,36,43,47,64,72,78,136,141,156,172,177,213,217,230,238],"secreted":[10],"in":[11,31,40,49,74,88,91,108,125,162,174,182],"the":[12,32,41,50,56,129,145,151,163,183,189,199,225],"human":[13,75,92,112,235],"adrenal":[14,76,93,113,143,236],"gland":[15],"by":[18],"3\u03b2-hydroxysteroid":[19],"dehydrogenase":[20],"(3\u03b2HSD),":[21],"17\u03b2-hydroxylase/17,20-lyase":[22],"(CYP17)":[23],"cytochrome":[25],"b5":[26],"(CYB5A).":[27],"3\u03b2HSD":[28,63,171,216],"expressed":[30],"zona":[33,44],"glomerulosa":[34],"(ZG)":[35],"fasciculata":[37],"(ZF),":[38],"CYP17":[39],"ZF":[42,71,229],"reticularis":[45],"(ZR)":[46],"CYB5A":[48,65,155,173,218],"ZR,":[51,231],"respectively.":[52],"We":[53],"previously":[54],"demonstrated":[55],"presence":[57],"cortical":[59],"parenchymal":[60],"cells":[61,82,101,227],"co-expressing":[62],"with":[66,234],"hybrid":[67,100,133,226],"features":[68],"both":[70,139,175,211],"ZR":[73],"cortex":[77],"hypothesized":[79],"that":[80,210],"these":[81,99],"may":[83],"play":[84],"an":[85],"important":[86],"role":[87],"androstenedione":[89,244],"production":[90],"gland.":[94],"Age-related":[95],"morphologic":[96],"development":[97,237],"has,":[102],"however,":[103],"not":[104],"been":[105],"studied.":[106],"Therefore,":[107],"this":[109,132],"study,":[110],"48":[111],"specimens":[114],"from":[115],"various":[116],"age":[117,201],"groups":[118,202],"were":[119,123,196],"retrieved.":[120],"Double-immunohistochemical":[121],"analyses":[122],"used":[124],"order":[126],"to":[127],"study":[128],"correlation":[130],"between":[131,170],"cell":[134],"type":[135],"age.":[137],"In":[138],"male":[140],"female":[142],"cortex,":[144],"means":[146],"total":[148,176],"adrenocortical":[149],"area,":[150],"area":[152,179,212],"positive":[153,220],"for":[154],"its":[157],"ratio":[158,214],"reached":[159],"highest":[160],"peak":[161],"21-40-year-old":[164],"(y.o.)":[165],"group.":[166,186],"The":[167],"greatest":[168],"overlap":[169],"relative":[178],"was":[180],"present":[181],"13-20":[184],"y.o.":[185],"For":[187],"all":[188],"markers":[190],"mentioned":[191],"above,":[192],"statistically":[193],"significant":[194],"differences":[195],"detected":[197],"among":[198],"different":[200],"examined":[203],"(p":[204],"<":[205],"0.05).":[206],"These":[207],"findings":[208],"indicated":[209],"double":[219],"cells,":[221],"which":[222],"could":[223,239],"represent":[224],"are":[232],"correlated":[233],"subsequently":[240],"influence":[241],"age-related":[242],"serum":[243],"levels.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}