{"id":"https://openalex.org/W19829832","doi":null,"title":"Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine.","display_name":"Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with n-butyl-n-(4-hydroxybutyl)nitrosamine.","publication_year":1980,"publication_date":"1980-08-01","ids":{"openalex":"https://openalex.org/W19829832","mag":"19829832","pmid":"https://pubmed.ncbi.nlm.nih.gov/7429086"},"language":"en","primary_location":{"id":"pmid:7429086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7429086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076174112","display_name":"\u656c\u4ecb \u4e2d\u897f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K Nakanishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Hirose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Hirose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Ogiso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ogiso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Hasegawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Arai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Arai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"N Ito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Ito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076174112"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8343,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.93411037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"71","issue":"4","first_page":"490","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-saccharin","display_name":"sodium saccharin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urinary-bladder-carcinogenesis","display_name":"urinary bladder carcinogenesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/n-butyl-n-4-hydroxybutyl-nitrosamine","display_name":"N-butyl-N-(4-hydroxybutyl)nitrosamine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bladder-hyperplasia","display_name":"bladder hyperplasia","score":0.7580000162124634},{"id":"https://openalex.org/keywords/bladder-papilloma","display_name":"bladder papilloma","score":0.7940000295639038},{"id":"https://openalex.org/keywords/chemical-carcinogenesis","display_name":"chemical carcinogenesis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/urothelium","display_name":"urothelium","score":0.8299999833106995},{"id":"https://openalex.org/keywords/food-additives","display_name":"food additives","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C2777395278","wikidata":"https://www.wikidata.org/wiki/Q413779","display_name":"Nitrosamine","level":3,"score":0.9071634411811829},{"id":"https://openalex.org/C2779147919","wikidata":"https://www.wikidata.org/wiki/Q191381","display_name":"Saccharin","level":2,"score":0.7948250770568848},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.7233611941337585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7116591334342957},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5188523530960083},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4731256365776062},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.420663982629776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33958548307418823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22062090039253235},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.17447715997695923},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16976401209831238},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1616421639919281}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002085","descriptor_name":"Butylhydroxybutylnitrosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003043","descriptor_name":"Cocarcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012439","descriptor_name":"Saccharin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7429086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7429086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan","raw_type":"Journal Article"},{"id":"mag:1481875778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7429086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:19829832","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/naid/40000529509","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Gann","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2026515218","https://openalex.org/W2315554044"],"related_works":["https://openalex.org/W429759776","https://openalex.org/W7036801474","https://openalex.org/W2304744447","https://openalex.org/W1977767802","https://openalex.org/W2044327148","https://openalex.org/W2006647195","https://openalex.org/W1883051139","https://openalex.org/W2049692059","https://openalex.org/W2415197339","https://openalex.org/W2045398568"],"abstract_inverted_index":{"The":[0,61],"effects":[1],"of":[2,76,85,90,98,107,119,126,153,161],"sodium":[3,34,52,77,99,130],"saccharin":[4,35,53,78,100,131],"and":[5,32,67,71,95,109,147],"caffeine":[6,37,55,154],"on":[7,141],"urinary":[8,62,124,144],"bladder":[9,125,145],"carcinogenesis":[10,162],"in":[11,122,133,163],"Wistar":[12],"strain":[13],"rats":[14,127],"treated":[15,47,128],"with":[16,49,88,101,112,129,155],"N-butyl-N-(4-hydroxybutyl)nitrosamine":[17],"(BBN)":[18],"were":[19,22,46,64],"studied.":[20],"Animals":[21],"given":[23],"0.01%":[24],"BBN":[25,80,91,102,113,156],"as":[26,38],"an":[27],"initiator":[28],"for":[29,40,56],"4":[30],"weeks":[31,42,58],"then":[33,65],"and/or":[36,54],"promoters":[39],"32":[41],"(Experiment":[43,59,93,115],"I),":[44,94],"or":[45,150],"simultaneously":[48],"0.001%":[50],"BBN,":[51],"40":[57],"II).":[60,116],"bladders":[63],"removed":[66],"examined":[68],"by":[69],"light":[70],"electron":[72],"microscopy.":[73],"Sequential":[74],"administration":[75,89,97,152],"after":[79],"significantly":[81,103],"enhanced":[82,104],"the":[83,105,123,142],"induction":[84,106],"hyperplasias":[86,120],"compared":[87,111],"alone":[92,114,132,137],"simultaneous":[96,151],"hyperplasia":[108],"papillomas":[110],"Two":[117],"types":[118],"developed":[121],"both":[134],"experiments.":[135,165],"Caffeine":[136],"had":[138],"no":[139,158],"effect":[140],"rat":[143],"epithelium,":[146],"either":[148],"sequential":[149],"caused":[157],"marked":[159],"enhancement":[160],"these":[164]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
