{"id":"https://openalex.org/W1982979779","doi":"https://doi.org/10.1111/cas.12309","title":"Downregulation of miR\u2010106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2","display_name":"Downregulation of miR\u2010106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2","publication_year":2013,"publication_date":"2013-10-25","ids":{"openalex":"https://openalex.org/W1982979779","doi":"https://doi.org/10.1111/cas.12309","mag":"1982979779","pmid":"https://pubmed.ncbi.nlm.nih.gov/24164962"},"language":"en","primary_location":{"id":"doi:10.1111/cas.12309","doi":"https://doi.org/10.1111/cas.12309","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.12309","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/cas.12309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102879336","display_name":"Xiaojian Ni","orcid":"https://orcid.org/0000-0003-0081-4162","observed_orcids":["https://orcid.org/0000-0003-0081-4162"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I4391767661","display_name":"State Key Laboratory of Reproductive Medicine","ror":"https://ror.org/00cagf561","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojian Ni","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","State Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003246573","display_name":"Tiansong Xia","orcid":"https://orcid.org/0000-0002-2039-3820","observed_orcids":["https://orcid.org/0000-0002-2039-3820","https://orcid.org/0009-0002-7896-665X"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiansong Xia","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007947547","display_name":"Yingchun Zhao","orcid":"https://orcid.org/0000-0002-8958-4406","observed_orcids":["https://orcid.org/0000-0002-8958-4406"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingchun Zhao","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037285225","display_name":"Wenbin Zhou","orcid":"https://orcid.org/0000-0003-1220-6797","observed_orcids":["https://orcid.org/0000-0003-1220-6797"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbin Zhou","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057150173","display_name":"Naping Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Naping Wu","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000288893","display_name":"Xiaoan Liu","orcid":"https://orcid.org/0000-0001-5716-0740","observed_orcids":["https://orcid.org/0000-0001-5716-0740"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoan Liu","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075256301","display_name":"Qiang Ding","orcid":"https://orcid.org/0000-0003-1499-6200","observed_orcids":["https://orcid.org/0000-0003-1499-6200"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Ding","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085196722","display_name":"Xiaoming Zha","orcid":"https://orcid.org/0000-0003-2604-811X","observed_orcids":["https://orcid.org/0000-0003-2604-811X"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoming Zha","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101801773","display_name":"Jiahao Sha","orcid":"https://orcid.org/0000-0002-4807-7547","observed_orcids":["https://orcid.org/0000-0002-4807-7547"]},"institutions":[{"id":"https://openalex.org/I4391767661","display_name":"State Key Laboratory of Reproductive Medicine","ror":"https://ror.org/00cagf561","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahao Sha","raw_affiliation_strings":["State Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing China","State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031110963","display_name":"Shui Wang","orcid":"https://orcid.org/0000-0001-8878-9162","observed_orcids":["https://orcid.org/0000-0001-8878-9162"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shui Wang","raw_affiliation_strings":["Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","Shui Wang, Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China","Tel: 0086-25-8371-8836 ext. 6456"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]},{"raw_affiliation_string":"Shui Wang, Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Tel: 0086-25-8371-8836 ext. 6456","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031110963"],"corresponding_institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":1.6582,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.82600262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"105","issue":"1","first_page":"18","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7149999737739563},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mir-106b","display_name":"miR-106b","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.953000009059906},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/bone-microenvironment","display_name":"bone microenvironment","score":0.8349999785423279},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.9587509632110596},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.7050763368606567},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6693204641342163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5907086133956909},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5870627760887146},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5005550384521484},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4776495695114136},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.45711493492126465},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4207567274570465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4016456604003906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37119361758232117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3308188319206238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2575005888938904},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24027115106582642},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20377960801124573},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1984230875968933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cas.12309","doi":"https://doi.org/10.1111/cas.12309","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.12309","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmid:24164962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24164962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3570583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4317878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317878","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/cas.12309","doi":"https://doi.org/10.1111/cas.12309","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.12309","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1965371218","https://openalex.org/W1976970049","https://openalex.org/W1978944350","https://openalex.org/W1986428743","https://openalex.org/W2038183997","https://openalex.org/W2043045795","https://openalex.org/W2047529648","https://openalex.org/W2050834003","https://openalex.org/W2054867367","https://openalex.org/W2087324367","https://openalex.org/W2087632489","https://openalex.org/W2093921289","https://openalex.org/W2102969047","https://openalex.org/W2112526783","https://openalex.org/W2121357141","https://openalex.org/W2135810600","https://openalex.org/W2138960046","https://openalex.org/W2151911276","https://openalex.org/W2167227856"],"related_works":["https://openalex.org/W2292402945","https://openalex.org/W640825770","https://openalex.org/W3031328390","https://openalex.org/W2081165140","https://openalex.org/W2188724532","https://openalex.org/W2387660152","https://openalex.org/W651850513","https://openalex.org/W2041650178","https://openalex.org/W2057896496","https://openalex.org/W2148294102"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,129],"(BC)":[2],"is":[3,87],"one":[4],"of":[5,22,40,108,140,156,167,178,182,187],"the":[6,18,38,72,83,91,106,152,173,185,195,202],"most":[7],"common":[8],"cancers":[9],"in":[10,75,82,98,111,116,221],"women,":[11],"and":[12,28,78,127,144,154,159,175,180,199,208,228],"it":[13],"can":[14],"often":[15],"metastasize":[16],"to":[17,45,63,102,105,135,193,205],"bone.":[19],"The":[20,165,234],"mechanism":[21],"BC":[23,68,84,112,157,222,245],"bone":[24,52,69,85,109,130,203,209,223,246],"metastasis":[25,86,110,224],"remains":[26],"unclear":[27],"requires":[29],"in-depth":[30],"investigation.":[31],"In":[32,90],"a":[33,121,137,239],"previous":[34],"study,":[35,93],"we":[36,94],"found":[37,95,192],"expression":[39,59,97,126],"matrix":[41],"metalloproteinase":[42],"2":[43],"(MMP2)":[44],"be":[46,64,103,136,238],"significantly":[47],"more":[48],"pronounced":[49],"at":[50,55],"metastatic":[51],"sites":[53],"than":[54],"orthotopic":[56,99,117],"sites.":[57],"MicroRNA":[58],"profiling":[60],"showed":[61,120,147],"miR-106b":[62,79,161,229],"markedly":[65],"downregulated":[66],"during":[67],"metastasis.":[70,131,210,247],"However,":[71],"specific":[73],"manner":[74],"which":[76],"MMP2":[77,96,125,132,149,168,183,189,215,232],"are":[80],"involved":[81],"still":[88],"unclear.":[89],"present":[92],"tumor":[100,118],"tissue":[101,119],"related":[104],"risk":[107],"patients.":[113],"MiR-106b":[114],"levels":[115],"negative":[122],"correlation":[123],"with":[124],"breast":[128],"was":[133,190],"shown":[134],"direct":[138],"target":[139,242],"miR-106b.":[141,188],"Both":[142],"gain-":[143],"loss-of-function":[145],"studies":[146],"that":[148,160,214],"could":[150,162],"promote":[151],"migration":[153],"invasion":[155],"cells":[158],"suppress":[163],"both.":[164],"blockage":[166],"by":[169],"RNA":[170],"interference":[171],"mimicked":[172],"anti-migration":[174],"anti-invasion":[176],"effects":[177],"miR-106b,":[179],"introduction":[181],"antagonized":[184],"function":[186],"also":[191],"regulate":[194],"ERK":[196,226],"signaling":[197],"cascade":[198],"so":[200],"adjust":[201],"microenvironment":[204],"favor":[206],"osteoclastogenesis":[207],"These":[211],"results":[212],"suggest":[213],"upregulation":[216],"plays":[217],"an":[218],"important":[219],"role":[220],"through":[225],"pathways,":[227],"directly":[230],"regulates":[231],"expression.":[233],"miR-106b/MMP2/ERK":[235],"pathway":[236],"may":[237],"promising":[240],"therapeutic":[241],"for":[243],"inhibiting":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
