{"id":"https://openalex.org/W1982978522","doi":"https://doi.org/10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","title":"Intra-tumoral application of a heregulin-exotoxin-A fusion protein causes rapid tumor regression without adverse systemic or local effects","display_name":"Intra-tumoral application of a heregulin-exotoxin-A fusion protein causes rapid tumor regression without adverse systemic or local effects","publication_year":1997,"publication_date":"1997-03-17","ids":{"openalex":"https://openalex.org/W1982978522","doi":"https://doi.org/10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","mag":"1982978522","pmid":"https://pubmed.ncbi.nlm.nih.gov/9096650"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","doi":"https://doi.org/10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110047411","display_name":"Bernd Groner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bernd Groner","raw_affiliation_strings":["Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056736436","display_name":"Bettina Wick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bettina Wick","raw_affiliation_strings":["Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103519188","display_name":"Margit Jeschke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margit Jeschke","raw_affiliation_strings":["CIBA, Pharmaceutical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBA, Pharmaceutical Research, Basel, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062304427","display_name":"Heinz\u2010Herbert Fiebig","orcid":"https://orcid.org/0000-0001-6222-7321","observed_orcids":["https://orcid.org/0000-0001-6222-7321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heinz-Herbert Fiebig","raw_affiliation_strings":["Oncotest, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncotest, Freiburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109947693","display_name":"W. A. Dengler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Dengler","raw_affiliation_strings":["Oncotest, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncotest, Freiburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069014407","display_name":"Tatiana Runau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana Runau","raw_affiliation_strings":["Oncotest, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncotest, Freiburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062696264","display_name":"Michael J\u00f6rg Mihatsch","orcid":"https://orcid.org/0009-0002-6925-9435","observed_orcids":["https://orcid.org/0009-0002-6925-9435"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Mihatsch","raw_affiliation_strings":["Kantonsspital Basel, Institut fu\u0308r Pathologie, Basel, Switzerland","Kantonsspital Basel, Institut f\u00fcr Pathologie, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital Basel, Institut fu\u0308r Pathologie, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Kantonsspital Basel, Institut f\u00fcr Pathologie, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086917724","display_name":"Ralf Kahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Kahl","raw_affiliation_strings":["Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040390294","display_name":"Mathias Schmidt","orcid":"https://orcid.org/0000-0003-0266-3994","observed_orcids":["https://orcid.org/0000-0003-0266-3994"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Schmidt","raw_affiliation_strings":["Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059562009","display_name":"Winfried S. Wels","orcid":"https://orcid.org/0000-0001-9858-3643","observed_orcids":["https://orcid.org/0000-0001-9858-3643"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Winfried Wels","raw_affiliation_strings":["Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026665082","display_name":"Elisabeth St\u00f6cklin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elisabeth St\u00f6cklin","raw_affiliation_strings":["Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110047411"],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.1634,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77846791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"6","first_page":"682","last_page":"687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.8399999737739563},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":0.9850000143051147},{"id":"https://openalex.org/keywords/breast-tumor-xenografts","display_name":"breast tumor xenografts","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.6850000023841858},{"id":"https://openalex.org/keywords/systemic-toxicity","display_name":"systemic toxicity","score":0.6610000133514404},{"id":"https://openalex.org/keywords/local-tumor-treatment","display_name":"local tumor treatment","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.537020742893219},{"id":"https://openalex.org/C182179738","wikidata":"https://www.wikidata.org/wiki/Q907386","display_name":"Pseudomonas exotoxin","level":4,"score":0.5340762138366699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5252068638801575},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4856971204280853},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4367055594921112},{"id":"https://openalex.org/C2778723905","wikidata":"https://www.wikidata.org/wiki/Q408649","display_name":"Exotoxin","level":3,"score":0.4340430796146393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4195571541786194},{"id":"https://openalex.org/C185323287","wikidata":"https://www.wikidata.org/wiki/Q59252204","display_name":"Neuregulin","level":3,"score":0.41305050253868103},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3535807728767395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21148458123207092},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.12150135636329651},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10515305399894714},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0980459451675415},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0674445629119873},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.0},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","doi":"https://doi.org/10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19970317)70:6<682::aid-ijc10>3.0.co;2-c","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:9096650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9096650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:18049","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/18049","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Cancer. - 70, 6 (1997) , 682-687, ISSN: 0020-7136","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1514463309","https://openalex.org/W1537158757","https://openalex.org/W1564868464","https://openalex.org/W1601571585","https://openalex.org/W1707332736","https://openalex.org/W1815468539","https://openalex.org/W1968788742","https://openalex.org/W1987657791","https://openalex.org/W1992373959","https://openalex.org/W1992821829","https://openalex.org/W2002058029","https://openalex.org/W2002708378","https://openalex.org/W2004628926","https://openalex.org/W2025904608","https://openalex.org/W2042849528","https://openalex.org/W2058810065","https://openalex.org/W2063576898","https://openalex.org/W2083935245","https://openalex.org/W2115782579","https://openalex.org/W2121619283","https://openalex.org/W2122518644","https://openalex.org/W2131462509","https://openalex.org/W2152991716","https://openalex.org/W2157519886","https://openalex.org/W2165319274"],"related_works":["https://openalex.org/W2025904608","https://openalex.org/W1532046759","https://openalex.org/W2110099898","https://openalex.org/W2092796888","https://openalex.org/W2122518644","https://openalex.org/W2086624267","https://openalex.org/W2912756192","https://openalex.org/W2002708378","https://openalex.org/W2063576898","https://openalex.org/W2080184949"],"abstract_inverted_index":{"Tumor":[0],"toxins":[1,62,153],"are":[2],"recombinant,":[3],"bifunctional":[4],"proteins":[5],"which":[6],"comprise":[7],"a":[8,25,85,109],"tumor-cell-specific":[9],"recognition":[10],"domain":[11],"and":[12,33,54,161],"an":[13],"enzymatic":[14],"toxin":[15,27],"domain.":[16],"We":[17],"have":[18],"evaluated":[19],"the":[20,31,120,122,134,144],"in":[21,79,143],"vivo":[22],"effects":[23],"of":[24,41,60,73,84,100,111,117,133,136,164],"tumor":[26,61,92,127,152,159,165],"that":[28,151],"specifically":[29],"recognizes":[30],"erbB-3":[32],"erbB-4":[34],"receptors":[35],"(HRG":[36],"beta":[37,43,75,102],"1-ETA).":[38],"High":[39],"doses":[40],"HRG":[42,74,101],"1-ETA":[44,76,103],"administered":[45],"systemically":[46],"(intracardially":[47],"or":[48],"intraperitoneally)":[49],"caused":[50],"acute":[51],"liver":[52,135],"necrosis":[53],"were":[55,129],"lethal.":[56],"The":[57,70,90],"same":[58],"dose":[59,146],"applied":[63],"subcutaneously":[64],"had":[65],"no":[66,126,140],"detectable":[67,130],"histopathological":[68],"effects.":[69],"anti-tumor":[71],"activity":[72],"was":[77,124],"tested":[78],"nude":[80],"mice":[81],"with":[82],"xenografts":[83],"human":[86],"breast":[87],"tumor,":[88],"MAXF1162.":[89],"MAXF1162":[91],"grew":[93],"rapidly":[94],"upon":[95],"s.c.":[96],"implantation.":[97],"Intra-tumoral":[98],"application":[99],"(7":[104],"times":[105],"5":[106],"micrograms":[107],"over":[108],"period":[110],"21":[112],"days)":[113],"induced":[114],"complete":[115],"regression":[116],"tumors.":[118],"At":[119],"time":[121],"treatment":[123,160],"terminated,":[125],"cells":[128],"microscopically.":[131],"Evaluation":[132],"treated":[137],"animals":[138],"revealed":[139],"significant":[141],"toxicity":[142],"effective":[145],"range.":[147],"These":[148],"experiments":[149],"indicate":[150],"can":[154],"become":[155],"valuable":[156],"for":[157,162],"local":[158],"reduction":[163],"burden.":[166]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}