{"id":"https://openalex.org/W1982976233","doi":"https://doi.org/10.1097/00007890-200001270-00003","title":"IG-THERASORB IMMUNOAPHERESIS IN ORTHOTOPIC XENOTRANSPLANTATION OF BABOONS WITH LANDRACE PIG HEARTS 1,2","display_name":"IG-THERASORB IMMUNOAPHERESIS IN ORTHOTOPIC XENOTRANSPLANTATION OF BABOONS WITH LANDRACE PIG HEARTS 1,2","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1982976233","doi":"https://doi.org/10.1097/00007890-200001270-00003","mag":"1982976233","pmid":"https://pubmed.ncbi.nlm.nih.gov/10670628"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-200001270-00003","doi":"https://doi.org/10.1097/00007890-200001270-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200001270-00003","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034696213","display_name":"Paolo Brenner","orcid":"https://orcid.org/0000-0002-8474-6154","observed_orcids":["https://orcid.org/0000-0002-8474-6154"]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Paolo Brenner","raw_affiliation_strings":["Department of Cardiac Surgery and Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Germany. Paolo.Brenner@hch.med.uni-muenchen.de","Paolo Brenner, M.D., Department of Cardiac Surgery, Klinikum Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany. E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery and Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Germany. Paolo.Brenner@hch.med.uni-muenchen.de","institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Paolo Brenner, M.D., Department of Cardiac Surgery, Klinikum Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany. E-mail","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076167190","display_name":"Hermann C. Reichenspurner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hermann Reichenspurner","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041871322","display_name":"Michael Schmoeckel","orcid":"https://orcid.org/0009-0005-2399-2836","observed_orcids":["https://orcid.org/0009-0005-2399-2836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Schmoeckel","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073434556","display_name":"C. Wimmer","orcid":"https://orcid.org/0000-0002-0709-1334","observed_orcids":["https://orcid.org/0000-0002-0709-1334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cosmas Wimmer","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexander Rucker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Rucker","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009811973","display_name":"Veronika Eder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronika Eder","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108091532","display_name":"Bruno Meiser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Meiser","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Hinz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hinz","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111570850","display_name":"Thomas W. Felbinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Felbinger","raw_affiliation_strings":["Institute of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126720","display_name":"Josef M\ufffdller-H\ufffdcker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josef M??ller-H??cker","raw_affiliation_strings":["Pathological Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathological Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108365672","display_name":"C. Hammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258122","display_name":"Institut f\u00fcr Chirurgische Forschung","ror":"https://ror.org/005506478","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405258122","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus Hammer","raw_affiliation_strings":["Institute for Surgical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Surgical Research","institution_ids":["https://openalex.org/I4405258122"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049461530","display_name":"Bruno Reichart","orcid":"https://orcid.org/0000-0003-2859-3664","observed_orcids":["https://orcid.org/0000-0003-2859-3664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Reichart","raw_affiliation_strings":["Department of Cardiac Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034696213"],"corresponding_institution_ids":["https://openalex.org/I4405258122","https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":3.4147,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.91894385,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"69","issue":"2","first_page":"208","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orthotopic-xenotransplantation","display_name":"orthotopic xenotransplantation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hyperacute-xenograft-rejection","display_name":"hyperacute xenograft rejection","score":0.9240000247955322},{"id":"https://openalex.org/keywords/immunoadsorption","display_name":"immunoadsorption","score":0.9110000133514404},{"id":"https://openalex.org/keywords/natural-antibodies","display_name":"natural antibodies","score":0.6690000295639038},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/immunoglobulin-removal","display_name":"immunoglobulin removal","score":0.6039999723434448},{"id":"https://openalex.org/keywords/xenotransplantation-immunology","display_name":"xenotransplantation immunology","score":0.6460000276565552},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.39500001072883606},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.3100000023841858},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.9504667520523071},{"id":"https://openalex.org/C3018622758","wikidata":"https://www.wikidata.org/wiki/Q7107413","display_name":"Miniature swine","level":2,"score":0.7306447625160217},{"id":"https://openalex.org/C2779839709","wikidata":"https://www.wikidata.org/wiki/Q1660148","display_name":"Immunoadsorption","level":3,"score":0.6438413858413696},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6425794363021851},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.5742732882499695},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.567295491695404},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5620208382606506},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5197572112083435},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5115600228309631},{"id":"https://openalex.org/C2778527173","wikidata":"https://www.wikidata.org/wiki/Q767508","display_name":"Miniature pig","level":2,"score":0.5007154941558838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44730302691459656},{"id":"https://openalex.org/C2994232697","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal circulation","level":2,"score":0.41328221559524536},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37955400347709656},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36050641536712646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35521355271339417},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2811717689037323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27406686544418335},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17143002152442932}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006386","descriptor_name":"Hemagglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006386","descriptor_name":"Hemagglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006386","descriptor_name":"Hemagglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006438","descriptor_name":"Hemodilution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006438","descriptor_name":"Hemodilution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006438","descriptor_name":"Hemodilution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-200001270-00003","doi":"https://doi.org/10.1097/00007890-200001270-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200001270-00003","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:10670628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10670628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4300000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W11274195","https://openalex.org/W881570366","https://openalex.org/W1618744733","https://openalex.org/W1997878438","https://openalex.org/W1999392138","https://openalex.org/W2015326385","https://openalex.org/W2017234187","https://openalex.org/W2026628669","https://openalex.org/W2032121728","https://openalex.org/W2052847242","https://openalex.org/W2064835686","https://openalex.org/W2065943556","https://openalex.org/W2083562172","https://openalex.org/W2084976001","https://openalex.org/W2114673753","https://openalex.org/W2411679176","https://openalex.org/W2412712475","https://openalex.org/W2416339144","https://openalex.org/W2416923622","https://openalex.org/W2419975464","https://openalex.org/W2430947798","https://openalex.org/W2466355634","https://openalex.org/W4210657423","https://openalex.org/W4229822560","https://openalex.org/W4233565841","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3087916313","https://openalex.org/W4299539663","https://openalex.org/W3175210674","https://openalex.org/W2042677470","https://openalex.org/W2057720437","https://openalex.org/W4233051719","https://openalex.org/W4243956322","https://openalex.org/W4240511025","https://openalex.org/W1975198612","https://openalex.org/W2472130023"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,229,239,333,383],"major":[2],"problem":[3],"of":[4,22,27,68,120,123,144,155,162,189,196,218,222,231,269,317,335,342,374,381],"xenotransplantation":[5,47],"is,":[6],"that":[7],"hyperacute":[8],"xenograft":[9,316,360],"rejection":[10],"(HXR)":[11],"causes":[12],"graft":[13,230],"failure":[14],"within":[15],"minutes":[16],"or":[17],"a":[18,32,96,126,134,194,206,358,387,419],"few":[19],"hours":[20],"because":[21],"natural":[23,53],"antibodies":[24,54],"and":[25,52,92,115,148,172,186,198,225,256,294,344],"activation":[26],"the":[28,49,82,87,104,160,163,202,212,232,250,257,311,315,318,327,336,349,365,398],"complement":[29,147,345],"system.":[30],"As":[31],"preclinical":[33,421],"model":[34],"we":[35,128,182],"transplanted":[36,129],"pig":[37,70,131,204,414],"hearts":[38,71,277],"orthotopically":[39],"into":[40,72,90,133],"baboons.":[41,382],"To":[42,192],"prevent":[43,193],"HXR":[44,378],"after":[45,180,236,247,253,260,306,331,361,379],"orthotopic":[46],"(oXHTx),":[48],"immunoglobulins":[50],"(Ig)":[51],"were":[55,151,157,303],"adsorbed":[56],"to":[57,81,103],"reusable":[58,388],"Ig-Therasorb":[59,105,366,384],"immunoadsorption":[60],"(IA)":[61],"columns.":[62],"METHODS:":[63],"We":[64],"performed":[65],"three":[66],"oXHTx":[67,241,252,259,380,405],"landrace":[69],"baboons":[73],"(19+/-6.8":[74],"kg),":[75],"using":[76],"extracorporeal":[77],"circulation":[78],"(ECC)":[79],"connected":[80],"IA":[83,219,243,307,337,400],"unit.":[84],"After":[85,271],"separating":[86],"recipient's":[88],"blood":[89],"plasma":[91,97,99],"cellular":[93],"fraction":[94],"by":[95,292,364],"filter,":[98],"flow":[100],"was":[101,244,290],"directed":[102],"column":[106,385],"coated":[107],"with":[108,242,310,326,348,397,412],"polyclonal":[109],"sheep-antibodies":[110],"against":[111],"human":[112],"IgG,":[113,223],"IgM,":[114,224],"IgA.":[116],"Intraoperative":[117],"treatment":[118],"consisted":[119],"4":[121,372],"cycles":[122,217,373],"IA.":[124,140,332],"For":[125,177],"control,":[127],"one":[130],"heart":[132,200],"baboon":[135],"(16.9":[136],"kg)":[137],"without":[138,282],"applying":[139],"Perioperatively,":[141],"serum":[142],"concentrations":[143],"Ig,":[145],"anti-pig-antibodies,":[146],"cardiac":[149,178,190,288,301],"enzymes":[150],"determined.":[152],"Tissue":[153],"samples":[154],"myocardium":[156,334],"collected":[158],"at":[159],"end":[161],"study":[164],"for":[165,423],"immunohistochemical":[166],"examinations,":[167],"light":[168],"microscopic":[169,174],"examination":[170,175],"(LM)":[171],"electron":[173],"(EM).":[176],"monitoring":[179],"oXHTx,":[181],"used":[183],"ECG,":[184],"echocardiography,":[185],"invasive":[187],"measurement":[188],"output.":[191],"mismatch":[195],"donor":[197,203,276],"recipient":[199,213],"size,":[201],"had":[205],"30-40%":[207],"lower":[208,305],"body":[209],"weight":[210],"than":[211],"baboon.":[214],"RESULTS:":[215],"Four":[216],"removed":[220],">80%":[221],"IgA":[226],"from":[227],"plasma.":[228],"control":[233,312,319,350],"animal":[234,320],"failed":[235],"29":[237],"min.":[238],"first":[240],"intentionally":[245],"terminated":[246],"100":[248],"min,":[249],"second":[251],"11":[254],"hr":[255],"third":[258],"21":[261],"hr.":[262],"All":[263],"xenografts":[264],"showed":[265,321],"no":[266],"histological":[267],"signs":[268],"HXR.":[270],"weaning":[272],"off":[273],"ECC,":[274],"these":[275],"worked":[278],"in":[279,324,395,404,410],"sinus":[280],"rhythm":[281],"electrocardiographic":[283],"ST-segment":[284],"elevation.":[285],"An":[286],"excellent":[287],"output":[289],"measured":[291],"echocardiography":[293],"thermodilution":[295],"(2":[296],"L/min).":[297],"Serological":[298],"parameters":[299],"indicating":[300],"damage":[302],"significantly":[304],"if":[308],"compared":[309,347],"experiment.":[313],"Macroscopically,":[314],"massive":[322],"hemorrhage":[323],"comparison":[325],"almost":[328],"inconspicuous":[329],"grafts":[330],"group":[338],"demonstrated":[339],"fewer":[340],"deposits":[341],"Ig":[343],"components":[346],"animal.":[351],"CONCLUSION:":[352],"Baboons":[353],"do":[354],"not":[355],"hyperacutely":[356],"reject":[357],"porcine":[359],"antibody":[362],"depletion":[363],"column.":[367],"In":[368],"our":[369],"experiment":[370],"only":[371],"immunoapheresis":[375],"effectively":[376],"prevented":[377],"is":[386],"device,":[389],"which":[390,416],"can":[391],"be":[392,402,418],"handled":[393],"easily":[394],"combination":[396,411],"ECC.":[399],"must":[401],"tested":[403],"longterm":[406],"survival":[407],"experiments,":[408],"especially":[409],"transgenic":[413],"organs,":[415],"could":[417],"reliable":[420],"approach":[422],"future":[424],"clinical":[425],"xenotransplantation.":[426]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
