{"id":"https://openalex.org/W1982974394","doi":"https://doi.org/10.1007/s00404-013-2977-7","title":"Effects of a combined treatment with tamoxifen and estrogen receptor \u03b2 agonists on human breast cancer cell lines","display_name":"Effects of a combined treatment with tamoxifen and estrogen receptor \u03b2 agonists on human breast cancer cell lines","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W1982974394","doi":"https://doi.org/10.1007/s00404-013-2977-7","mag":"1982974394","pmid":"https://pubmed.ncbi.nlm.nih.gov/23907354"},"language":"en","primary_location":{"id":"doi:10.1007/s00404-013-2977-7","doi":"https://doi.org/10.1007/s00404-013-2977-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00404-013-2977-7","pdf_url":null,"source":{"id":"https://openalex.org/S568598","display_name":"Archives of Gynecology and Obstetrics","issn_l":"0003-9128","issn":["0003-9128","0170-9925","0932-0067","1432-0711"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Gynecology and Obstetrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110118675","display_name":"Claus Lattrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claus Lattrich","raw_affiliation_strings":["Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany, clattrich@caritasstjosef.de","University Medical Center Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany, clattrich@caritasstjosef.de","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"University Medical Center Regensburg","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000323086","display_name":"Susanne Sch\u00fcler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Sch\u00fcler","raw_affiliation_strings":["Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","University Medical Center Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"University Medical Center Regensburg","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113767274","display_name":"Julia H\u00e4ring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia H\u00e4ring","raw_affiliation_strings":["Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","University Medical Center Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"University Medical Center Regensburg","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033654048","display_name":"Maciej Skrzypczak","orcid":"https://orcid.org/0000-0002-1289-5900","observed_orcids":["https://orcid.org/0000-0002-1289-5900"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maciej Skrzypczak","raw_affiliation_strings":["Second Department of Gynecology, Medical University of Lublin, Lublin, Poland","Medical university of Lublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Gynecology, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]},{"raw_affiliation_string":"Medical university of Lublin","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036428735","display_name":"Olaf Ortmann","orcid":"https://orcid.org/0000-0001-6238-3949","observed_orcids":["https://orcid.org/0000-0001-6238-3949"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Ortmann","raw_affiliation_strings":["Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","University Medical Center Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"University Medical Center Regensburg","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087151081","display_name":"Oliver Treeck","orcid":"https://orcid.org/0000-0003-2353-9693","observed_orcids":["https://orcid.org/0000-0003-2353-9693"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Treeck","raw_affiliation_strings":["Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","University Medical Center Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab Molecular Oncology, Department of Gynecology and Obstetrics, University Medical Center Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]},{"raw_affiliation_string":"University Medical Center Regensburg","institution_ids":["https://openalex.org/I3129555431"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110118675"],"corresponding_institution_ids":["https://openalex.org/I3129555431"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.4401,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.76747645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"289","issue":"1","first_page":"163","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9319999814033508},{"id":"https://openalex.org/keywords/estrogen-receptor-beta-agonist","display_name":"estrogen receptor beta agonist","score":0.9240000247955322},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":1.0},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.9470000267028809},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6700000166893005},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cd177","display_name":"CD177","score":0.9010000228881836},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.9342153072357178},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7502081394195557},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7095113396644592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.643996000289917},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.5815041065216064},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.572192907333374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4962192177772522},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.47376397252082825},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4320264160633087},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4304896295070648},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42509639263153076},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4244576692581177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41978663206100464},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36293017864227295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20498287677764893},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00404-013-2977-7","doi":"https://doi.org/10.1007/s00404-013-2977-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00404-013-2977-7","pdf_url":null,"source":{"id":"https://openalex.org/S568598","display_name":"Archives of Gynecology and Obstetrics","issn_l":"0003-9128","issn":["0003-9128","0170-9925","0932-0067","1432-0711"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Gynecology and Obstetrics","raw_type":"journal-article"},{"id":"pmid:23907354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23907354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of gynecology and obstetrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W159567683","https://openalex.org/W1538903611","https://openalex.org/W1592175547","https://openalex.org/W1758347721","https://openalex.org/W1967004474","https://openalex.org/W1979662506","https://openalex.org/W1981125500","https://openalex.org/W1983556621","https://openalex.org/W1984984201","https://openalex.org/W1985213868","https://openalex.org/W1996899827","https://openalex.org/W2003627629","https://openalex.org/W2009152490","https://openalex.org/W2029521041","https://openalex.org/W2058539819","https://openalex.org/W2085600503","https://openalex.org/W2092099059","https://openalex.org/W2104654854","https://openalex.org/W2107277218","https://openalex.org/W2124649441","https://openalex.org/W2127603929","https://openalex.org/W2133010239","https://openalex.org/W2143675738","https://openalex.org/W2159089057","https://openalex.org/W2165298876","https://openalex.org/W2166542841","https://openalex.org/W4245012876"],"related_works":["https://openalex.org/W2314907800","https://openalex.org/W2348705960","https://openalex.org/W2404137019","https://openalex.org/W1500059225","https://openalex.org/W2415909835","https://openalex.org/W2029521041","https://openalex.org/W2944800867","https://openalex.org/W4224547507","https://openalex.org/W191998226","https://openalex.org/W2018326998"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}