{"id":"https://openalex.org/W1982966939","doi":"https://doi.org/10.1038/srep02584","title":"In Vitro Hematological and In Vivo Vasoactivity Assessment of Dextran Functionalized Graphene","display_name":"In Vitro Hematological and In Vivo Vasoactivity Assessment of Dextran Functionalized Graphene","publication_year":2013,"publication_date":"2013-09-03","ids":{"openalex":"https://openalex.org/W1982966939","doi":"https://doi.org/10.1038/srep02584","mag":"1982966939","pmid":"https://pubmed.ncbi.nlm.nih.gov/24002570"},"language":"en","primary_location":{"id":"doi:10.1038/srep02584","doi":"https://doi.org/10.1038/srep02584","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep02584","pdf_url":"https://www.nature.com/articles/srep02584.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep02584.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103072443","display_name":"Sayan Mullick Chowdhury","orcid":"https://orcid.org/0000-0002-0502-7531","observed_orcids":["https://orcid.org/0000-0002-0502-7531"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayan Mullick Chowdhury","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook, NY","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012589680","display_name":"Shruti Kanakia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Kanakia","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook, NY","Department of Biomedical Engineering, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook, NY","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002308317","display_name":"Jimmy D. Toussaint","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy D. Toussaint","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook, NY","Department of Biomedical Engineering, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook, NY","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085199685","display_name":"Mary D. S. Frame","orcid":"https://orcid.org/0000-0003-3890-2221","observed_orcids":["https://orcid.org/0000-0003-3890-2221"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary D. Frame","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook, NY","Department of Biomedical Engineering, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook, NY","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088061096","display_name":"Anthony M Dewar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony M. Dewar","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook, NY","Department of Biomedical Engineering, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook, NY","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108230633","display_name":"Kenneth R. Shroyer","orcid":"https://orcid.org/0000-0001-8090-0778","observed_orcids":["https://orcid.org/0000-0001-8090-0778"]},"institutions":[{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth R. Shroyer","raw_affiliation_strings":["Department of Pathology, Stony Brook, NY","Department of Pathology, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stony Brook, NY","institution_ids":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Pathology, Stony Brook","institution_ids":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Moore","raw_affiliation_strings":["Department of Radiology Stony Brook University, Stony Brook, NY","Department of Radiology Stony Brook University, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Stony Brook University, Stony Brook, NY","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Radiology Stony Brook University, Stony Brook","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064131235","display_name":"Balaji Sitharaman","orcid":"https://orcid.org/0000-0001-8391-8076","observed_orcids":["https://orcid.org/0000-0001-8391-8076"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balaji Sitharaman","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook, NY","Department of Biomedical Engineering, Stony Brook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook, NY","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.7214,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.92838737,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"2584","last_page":"2584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10083","display_name":"Graphene research and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphene-nanoplatelets","display_name":"graphene nanoplatelets","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.49799999594688416},{"id":"https://openalex.org/keywords/hemocompatibility","display_name":"hemocompatibility","score":0.7080000042915344},{"id":"https://openalex.org/keywords/vascular-reactivity","display_name":"vascular reactivity","score":0.796999990940094},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hamster-cheek-pouch-model","display_name":"hamster cheek pouch model","score":0.8330000042915344},{"id":"https://openalex.org/keywords/arteriolar-dilation","display_name":"arteriolar dilation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.36399999260902405}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8094201683998108},{"id":"https://openalex.org/C34439696","wikidata":"https://www.wikidata.org/wiki/Q95539","display_name":"Cheek pouch","level":3,"score":0.705442488193512},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.6765816807746887},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6596239805221558},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6015012264251709},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.5977743864059448},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5340999364852905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5308035016059875},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4885576665401459},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4384540915489197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29690444469451904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2799188494682312},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2411213219165802},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.23529431223869324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22297975420951843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20993733406066895},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006108","descriptor_name":"Graphite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010978","descriptor_name":"Platelet Factor 4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010978","descriptor_name":"Platelet Factor 4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010978","descriptor_name":"Platelet Factor 4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep02584","doi":"https://doi.org/10.1038/srep02584","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep02584","pdf_url":"https://www.nature.com/articles/srep02584.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:24002570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24002570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2755411","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3761081","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3761081","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3761081","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep02584","doi":"https://doi.org/10.1038/srep02584","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep02584","pdf_url":"https://www.nature.com/articles/srep02584.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306300","display_name":"Wallace H. Coulter Foundation","ror":"https://ror.org/04cmszv87"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982966939.pdf","grobid_xml":"https://content.openalex.org/works/W1982966939.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W38762921","https://openalex.org/W46469852","https://openalex.org/W71881804","https://openalex.org/W1576280122","https://openalex.org/W1965283009","https://openalex.org/W1966528464","https://openalex.org/W1969276387","https://openalex.org/W1977791017","https://openalex.org/W1977791081","https://openalex.org/W1981315388","https://openalex.org/W1989037178","https://openalex.org/W1994585094","https://openalex.org/W1994797655","https://openalex.org/W1997319017","https://openalex.org/W1997990070","https://openalex.org/W2002062311","https://openalex.org/W2002961488","https://openalex.org/W2007616480","https://openalex.org/W2008923772","https://openalex.org/W2012588499","https://openalex.org/W2013328140","https://openalex.org/W2015546204","https://openalex.org/W2019985255","https://openalex.org/W2021691065","https://openalex.org/W2022394525","https://openalex.org/W2027268803","https://openalex.org/W2029991316","https://openalex.org/W2034039747","https://openalex.org/W2048942846","https://openalex.org/W2052334189","https://openalex.org/W2053411326","https://openalex.org/W2063802580","https://openalex.org/W2065321765","https://openalex.org/W2065795135","https://openalex.org/W2078061467","https://openalex.org/W2081849883","https://openalex.org/W2085733813","https://openalex.org/W2088693256","https://openalex.org/W2092893933","https://openalex.org/W2094511343","https://openalex.org/W2103190994","https://openalex.org/W2106088947","https://openalex.org/W2109477306","https://openalex.org/W2113253343","https://openalex.org/W2121621337","https://openalex.org/W2128858080","https://openalex.org/W2133217987","https://openalex.org/W2136171760","https://openalex.org/W2145237811","https://openalex.org/W2157235905","https://openalex.org/W2165069088","https://openalex.org/W2165463540","https://openalex.org/W2167815042","https://openalex.org/W2201589108","https://openalex.org/W2326443463","https://openalex.org/W2334435507","https://openalex.org/W2409459743"],"related_works":["https://openalex.org/W2002253011","https://openalex.org/W1518581938","https://openalex.org/W2032970786","https://openalex.org/W2047519792","https://openalex.org/W1999359082","https://openalex.org/W131825119","https://openalex.org/W2146131768","https://openalex.org/W57335222","https://openalex.org/W2414468835","https://openalex.org/W2020720552"],"abstract_inverted_index":{"The":[0,53],"intravenous,":[1],"intramuscular":[2],"or":[3,99],"intraperitoneal":[4],"administration":[5],"of":[6,31,80,114,125],"water":[7],"solubilized":[8],"graphene":[9,34],"nanoparticles":[10],"for":[11],"biomedical":[12],"applications":[13],"will":[14],"result":[15],"in":[16,47,51,78,108,134],"their":[17],"interaction":[18],"with":[19],"the":[20,29,104,111,122],"hematological":[21],"components":[22],"and":[23,49,68,85,136],"vasculature.":[24],"Herein,":[25],"we":[26],"have":[27],"investigated":[28],"effects":[30],"dextran":[32],"functionalized":[33],"nanoplatelets":[35],"(GNP-Dex)":[36],"on":[37],"histamine":[38,60],"release,":[39],"platelet":[40,97],"activation,":[41,43],"immune":[42],"blood":[44,100],"cell":[45,101],"hemolysis":[46],"vitro,":[48],"vasoactivity":[50,113],"vivo.":[52],"results":[54],"indicate":[55],"that":[56],"GNP-Dex":[57,92,115],"formulations":[58,93],"prevented":[59],"release":[61],"from":[62],"activated":[63],"RBL-2H3":[64],"rat":[65],"mast":[66],"cells,":[67],"at":[69,116],"concentrations":[70,117],"\u2265":[71],"7":[72],"mg/ml,":[73],"showed":[74],"a":[75,126,130,144],"12-20%":[76],"increase":[77],"levels":[79,87],"complement":[81],"proteins.":[82],"Cytokine":[83],"(TNF-Alpha":[84],"IL-10)":[86],"remained":[88],"within":[89],"normal":[90],"range.":[91],"did":[94,141],"not":[95,142],"cause":[96],"activation":[98],"hemolysis.":[102],"Using":[103],"hamster":[105],"cheek":[106],"pouch":[107],"vivo":[109],"model,":[110],"initial":[112],"(1-50":[118],"mg/ml)":[119],"equivalent":[120],"to":[121],"first":[123],"pass":[124],"bolus":[127],"injection":[128],"was":[129],"brief":[131],"concentration-dependent":[132],"dilation":[133],"arcade":[135],"terminal":[137],"arterioles.":[138],"However,":[139],"they":[140],"induce":[143],"pro-inflammatory":[145],"endothelial":[146],"dysfunction":[147],"effect.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
