{"id":"https://openalex.org/W1982965160","doi":"https://doi.org/10.1016/j.fitote.2011.07.001","title":"Long-term treatment with standardized Ginkgo biloba Extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia","display_name":"Long-term treatment with standardized Ginkgo biloba Extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia","publication_year":2011,"publication_date":"2011-07-29","ids":{"openalex":"https://openalex.org/W1982965160","doi":"https://doi.org/10.1016/j.fitote.2011.07.001","mag":"1982965160","pmid":"https://pubmed.ncbi.nlm.nih.gov/21820038"},"language":"en","primary_location":{"id":"doi:10.1016/j.fitote.2011.07.001","doi":"https://doi.org/10.1016/j.fitote.2011.07.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fitote.2011.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S44811770","display_name":"Fitoterapia","issn_l":"0367-326X","issn":["0367-326X","1873-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111568886","display_name":"Marie\u2010Noelle Rocher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Noelle Rocher","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022795815","display_name":"Denis Carr\u00e9","orcid":"https://orcid.org/0000-0003-3222-2137","observed_orcids":["https://orcid.org/0000-0003-3222-2137"]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Carr\u00e9","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084660598","display_name":"Brigitte Spinnewyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Brigitte Spinnewyn","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070569368","display_name":"Jocelyne Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jocelyne Schulz","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025846888","display_name":"Sylvie Delaflotte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Delaflotte","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057450242","display_name":"Bernadette Pignol","orcid":"https://orcid.org/0000-0003-2025-5249","observed_orcids":["https://orcid.org/0000-0003-2025-5249"]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernadette Pignol","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113657250","display_name":"Pierre\u2010Etienne Chabrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Etienne Chabrier","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103401031","display_name":"Michel Auguet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Auguet","raw_affiliation_strings":["Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen Innovation. 5, Avenue du Canada, 91940 Les Ulis, France","institution_ids":["https://openalex.org/I183367347"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084660598"],"corresponding_institution_ids":["https://openalex.org/I183367347"],"apc_list":{"value":3950,"currency":"USD","value_usd":3950},"apc_paid":null,"fwci":9.3806,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.9677037,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"82","issue":"7","first_page":"1075","last_page":"1080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12846","display_name":"Ginkgo biloba and Cashew Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12846","display_name":"Ginkgo biloba and Cashew Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ginkgo-biloba-extract-egb-761","display_name":"Ginkgo biloba extract EGb 761","score":0.9620000123977661},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hippocampal-neuronal-loss","display_name":"hippocampal neuronal loss","score":0.746999979019165},{"id":"https://openalex.org/keywords/ca1-neurons","display_name":"CA1 neurons","score":0.9049999713897705},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.8949999809265137},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.777999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gerbil-model","display_name":"gerbil model","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6710000038146973},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C2778998842","wikidata":"https://www.wikidata.org/wiki/Q43284","display_name":"Ginkgo biloba","level":2,"score":0.9817787408828735},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.8158859014511108},{"id":"https://openalex.org/C2780222073","wikidata":"https://www.wikidata.org/wiki/Q649817","display_name":"Gerbil","level":3,"score":0.789174497127533},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7218667268753052},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6721543073654175},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5628329515457153},{"id":"https://openalex.org/C2779706397","wikidata":"https://www.wikidata.org/wiki/Q149461","display_name":"Ginkgo","level":2,"score":0.540611743927002},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5402725338935852},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49048635363578796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4395424723625183},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3415612578392029},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32160189747810364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2543843388557434},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.18600872159004211},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.1588539183139801},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000096983","descriptor_name":"Ginkgo Extract","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015140","descriptor_name":"Dementia, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020441","descriptor_name":"Ginkgo biloba","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.fitote.2011.07.001","doi":"https://doi.org/10.1016/j.fitote.2011.07.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fitote.2011.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S44811770","display_name":"Fitoterapia","issn_l":"0367-326X","issn":["0367-326X","1873-6971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"journal-article"},{"id":"pmid:21820038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21820038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fitoterapia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W10277917","https://openalex.org/W98726755","https://openalex.org/W114357233","https://openalex.org/W133907179","https://openalex.org/W195525667","https://openalex.org/W1578359906","https://openalex.org/W1968922340","https://openalex.org/W1972305402","https://openalex.org/W1995710077","https://openalex.org/W2000078561","https://openalex.org/W2001136741","https://openalex.org/W2001290273","https://openalex.org/W2003432290","https://openalex.org/W2013290019","https://openalex.org/W2020105395","https://openalex.org/W2020622209","https://openalex.org/W2034601808","https://openalex.org/W2038072430","https://openalex.org/W2040369419","https://openalex.org/W2046645942","https://openalex.org/W2049086704","https://openalex.org/W2051936520","https://openalex.org/W2058454186","https://openalex.org/W2059215368","https://openalex.org/W2072707752","https://openalex.org/W2089254591","https://openalex.org/W2099442368","https://openalex.org/W2101471222","https://openalex.org/W2122891448","https://openalex.org/W2122947129","https://openalex.org/W2124002387","https://openalex.org/W2124440066","https://openalex.org/W2132977458","https://openalex.org/W2144529104","https://openalex.org/W2168144334","https://openalex.org/W2274758589","https://openalex.org/W2336167520","https://openalex.org/W6604646912"],"related_works":["https://openalex.org/W3031980139","https://openalex.org/W2374845574","https://openalex.org/W1538555434","https://openalex.org/W2406213327","https://openalex.org/W2390120368","https://openalex.org/W3142956060","https://openalex.org/W4220758446","https://openalex.org/W2049086704","https://openalex.org/W2878843440","https://openalex.org/W2488197469"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}