{"id":"https://openalex.org/W1982964683","doi":"https://doi.org/10.1021/ac400688f","title":"Cell-Based Drug Combination Screening with a Microfluidic Droplet Array System","display_name":"Cell-Based Drug Combination Screening with a Microfluidic Droplet Array System","publication_year":2013,"publication_date":"2013-06-20","ids":{"openalex":"https://openalex.org/W1982964683","doi":"https://doi.org/10.1021/ac400688f","mag":"1982964683","pmid":"https://pubmed.ncbi.nlm.nih.gov/23786644"},"language":"en","primary_location":{"id":"doi:10.1021/ac400688f","doi":"https://doi.org/10.1021/ac400688f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac400688f","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040746847","display_name":"Guan-Sheng Du","orcid":"https://orcid.org/0000-0003-1810-3051","observed_orcids":["https://orcid.org/0000-0003-1810-3051"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]},{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["CN","NL"],"is_corresponding":false,"raw_author_name":"Guan-Sheng Du","raw_affiliation_strings":["Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","Materials Technology Institute, Eindhoven University of Technology, Eindhoven, 5600MB,\rThe Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Materials Technology Institute, Eindhoven University of Technology, Eindhoven, 5600MB,\rThe Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060311326","display_name":"Jian\u2010Zhang Pan","orcid":"https://orcid.org/0000-0001-8164-7161","observed_orcids":["https://orcid.org/0000-0001-8164-7161"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Zhang Pan","raw_affiliation_strings":["Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014288270","display_name":"Shi-Ping Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-Ping Zhao","raw_affiliation_strings":["Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006092446","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0002-5416-0566","observed_orcids":["https://orcid.org/0000-0002-5416-0566","https://orcid.org/0009-0003-7717-7090"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023602901","display_name":"Jaap M. J. den Toonder","orcid":"https://orcid.org/0000-0002-5923-4456","observed_orcids":["https://orcid.org/0000-0002-5923-4456"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jaap M.J. den Toonder","raw_affiliation_strings":["Materials Technology Institute, Eindhoven University of Technology, Eindhoven, 5600MB,\rThe Netherlands","Philips Research, Eindhoven, 5656AE, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Technology Institute, Eindhoven University of Technology, Eindhoven, 5600MB,\rThe Netherlands","institution_ids":["https://openalex.org/I83019370"]},{"raw_affiliation_string":"Philips Research, Eindhoven, 5656AE, The Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051941824","display_name":"Qun Fang","orcid":"https://orcid.org/0000-0002-6250-252X","observed_orcids":["https://orcid.org/0000-0002-6250-252X"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qun Fang","raw_affiliation_strings":["Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microanalytical\rSystems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Microanalytical#R#Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051941824"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.7471,"has_fulltext":false,"cited_by_count":141,"citation_normalized_percentile":{"value":0.97350883,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"85","issue":"14","first_page":"6740","last_page":"6747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-combination-screening","display_name":"drug combination screening","score":0.890999972820282},{"id":"https://openalex.org/keywords/droplet-microfluidics","display_name":"droplet microfluidics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/long-term-cell-culture","display_name":"long-term cell culture","score":0.7120000123977661},{"id":"https://openalex.org/keywords/flavopiridol","display_name":"flavopiridol","score":0.8399999737739563},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.984000027179718},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6710000038146973},{"id":"https://openalex.org/keywords/drug-consumption-reduction","display_name":"drug consumption reduction","score":0.6100000143051147},{"id":"https://openalex.org/keywords/droplet-manipulation","display_name":"droplet manipulation","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7880465984344482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7436153292655945},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6742425560951233},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5112836360931396},{"id":"https://openalex.org/C50712719","wikidata":"https://www.wikidata.org/wiki/Q446473","display_name":"Syringe driver","level":3,"score":0.4774625599384308},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4592653512954712},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.44672995805740356},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.44545602798461914},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4073527455329895},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3743184208869934},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34544312953948975},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20097005367279053},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1363827884197235},{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.11175486445426941},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11027255654335022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10840269923210144},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10306486487388611},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07075375318527222},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1021/ac400688f","doi":"https://doi.org/10.1021/ac400688f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac400688f","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:23786644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23786644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.tue.nl:openaire_cris_publications/1837301e-33a5-4915-82eb-8c11ec9fc901","doi":null,"is_oa":false,"landing_page_url":"https://research.tue.nl/en/publications/1837301e-33a5-4915-82eb-8c11ec9fc901","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Du, G, Pan, J, Zhao, S, Zhu, Y, Toonder, den, J M J & Fang, Q 2013, 'Cell-based drug combination screening with a microfluidic droplet array system', Analytical Chemistry, vol. 85, no. 14, pp. 6740-6747. https://doi.org/10.1021/ac400688f","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:757833","doi":null,"is_oa":false,"landing_page_url":"http://library.tue.nl/csp/dare/LinkToRepository.csp?recordnumber=757833","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN:0003-2700","raw_type":"Article / Letter to the editor"},{"id":"pmh:oai:library.tue.nl:757833","doi":null,"is_oa":false,"landing_page_url":"http://repository.tue.nl/757833","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN:0003-2700","raw_type":"Article / Letter to the editor"},{"id":"pmh:tue:oai:library.tue.nl:757833","doi":null,"is_oa":false,"landing_page_url":"http://repository.tue.nl/757833","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analytical Chemistry Analytical Chemistry Analytical Chemistry, 85(14), 6740","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:tue:oai:pure.tue.nl:publications/1837301e-33a5-4915-82eb-8c11ec9fc901","doi":null,"is_oa":false,"landing_page_url":"https://research.tue.nl/nl/publications/1837301e-33a5-4915-82eb-8c11ec9fc901","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analytical Chemistry, 85(14), 6740 - 6747. American Chemical Society","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1483995411","https://openalex.org/W1495058242","https://openalex.org/W1973932751","https://openalex.org/W1973965902","https://openalex.org/W1975581000","https://openalex.org/W1979289112","https://openalex.org/W1980221373","https://openalex.org/W1981190303","https://openalex.org/W1992741965","https://openalex.org/W1996318693","https://openalex.org/W2005393395","https://openalex.org/W2026908430","https://openalex.org/W2028333733","https://openalex.org/W2028977508","https://openalex.org/W2037139573","https://openalex.org/W2045615971","https://openalex.org/W2052631387","https://openalex.org/W2059944938","https://openalex.org/W2062941476","https://openalex.org/W2067315058","https://openalex.org/W2073137330","https://openalex.org/W2075734906","https://openalex.org/W2097654801","https://openalex.org/W2098999080","https://openalex.org/W2103562758","https://openalex.org/W2104645521","https://openalex.org/W2112525270","https://openalex.org/W2126750664","https://openalex.org/W2131549312","https://openalex.org/W2135594199","https://openalex.org/W2140474512","https://openalex.org/W2148810752","https://openalex.org/W2165948908","https://openalex.org/W2318289184","https://openalex.org/W2323990297","https://openalex.org/W2329040020","https://openalex.org/W2330919994","https://openalex.org/W3024436806"],"related_works":["https://openalex.org/W2982536989","https://openalex.org/W3209923813","https://openalex.org/W3167990994","https://openalex.org/W2085248918","https://openalex.org/W2397146032","https://openalex.org/W2034054031","https://openalex.org/W4283360406","https://openalex.org/W2965259091","https://openalex.org/W4383373863","https://openalex.org/W2900561911"],"abstract_inverted_index":{"We":[0],"performed":[1,112],"cell-based":[2,221],"drug":[3,64,74,137,150,180,200],"combination":[4,65,138,169],"screening":[5,66,139,184,201,222],"using":[6,91],"an":[7,46],"integrated":[8],"droplet-based":[9,216],"microfluidic":[10,217],"system":[11,131],"based":[12],"on":[13],"the":[14,22,53,87,120,147],"sequential":[15],"operation":[16,227],"droplet":[17,36,41,89,93,125],"array":[18,42],"(SODA)":[19],"technique.":[20],"In":[21],"system,":[23],"a":[24,29,167,212],"tapered":[25],"capillary":[26],"connected":[27],"with":[28,146,166,198,203,223],"syringe":[30],"pump":[31],"was":[32,50,111,132,164,186],"used":[33,51],"for":[34,55,63,140,182,219],"multistep":[35,61,226],"manipulations.":[37],"An":[38],"oil-covered":[39,114],"two-dimensional":[40],"chip":[43],"fixed":[44],"in":[45,84,86,113,123,134],"x-y-z":[47],"translation":[48],"stage":[49],"as":[52,106,108],"platform":[54],"cell":[56,69,79,104,148],"culture":[57,105,121],"and":[58,76,78,101,152,158,214,225],"analysis.":[59],"Complex":[60],"operations":[62],"involving":[67],"long-term":[68],"culture,":[70],"medium":[71,122],"changing,":[72],"schedule-dependent":[73,136],"dosage":[75],"stimulation,":[77],"viability":[80],"testing":[81],"were":[82],"achieved":[83],"parallel":[85,135],"semiopen":[88],"array,":[90],"multiple":[92],"manipulations":[94],"including":[95],"liquid":[96],"metering,":[97],"aspirating,":[98],"depositing,":[99],"mixing,":[100],"transferring.":[102],"Long-term":[103],"long":[107],"11":[109],"days":[110],"500":[115],"nL":[116],"droplets":[117],"by":[118,175],"changing":[119],"each":[124,183],"every":[126],"24":[127],"h.":[128],"The":[129,160,179,208],"present":[130,209],"applied":[133],"A549":[141],"nonsmall":[142],"lung":[143],"cancer":[144],"cells":[145],"cycle-dependent":[149],"flavopiridol":[151,173],"two":[153],"anticancer":[154],"drugs":[155],"of":[156,170],"paclitaxel":[157],"5-fluorouracil.":[159,178],"highest":[161],"inhibition":[162],"efficiency":[163],"obtained":[165],"schedule":[168],"200":[171],"nM":[172],"followed":[174],"100":[176],"\u03bcM":[177],"consumption":[181],"test":[185],"substantially":[187],"decreased":[188],"to":[189,194],"5":[190],"ng-5":[191],"\u03bcg,":[192],"corresponding":[193],"10-1000-fold":[195],"reductions":[196],"compared":[197],"traditional":[199],"systems":[202],"96-well":[204],"or":[205],"384-well":[206],"plates.":[207],"work":[210],"provides":[211],"novel":[213],"flexible":[215],"approach":[218],"performing":[220],"complex":[224],"procedures.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
