{"id":"https://openalex.org/W1982959887","doi":"https://doi.org/10.1038/nrn3012","title":"Linking lipids to Alzheimer's disease: cholesterol and beyond","display_name":"Linking lipids to Alzheimer's disease: cholesterol and beyond","publication_year":2011,"publication_date":"2011-03-30","ids":{"openalex":"https://openalex.org/W1982959887","doi":"https://doi.org/10.1038/nrn3012","mag":"1982959887","pmid":"https://pubmed.ncbi.nlm.nih.gov/21448224"},"language":"en","primary_location":{"id":"doi:10.1038/nrn3012","doi":"https://doi.org/10.1038/nrn3012","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn3012","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3321383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073890226","display_name":"Gilbert Di Paolo","orcid":"https://orcid.org/0000-0003-1032-1265","observed_orcids":["https://orcid.org/0000-0003-1032-1265"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gilbert Di Paolo","raw_affiliation_strings":["Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA. gil.dipaolo@columbia.edu","Department of Pathology & Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA. gil.dipaolo@columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pathology & Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center New York USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100329533","display_name":"Taewan Kim","orcid":"https://orcid.org/0000-0002-4055-7781","observed_orcids":["https://orcid.org/0000-0002-4055-7781","https://orcid.org/0000-0001-9072-5838"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tae-Wan Kim","raw_affiliation_strings":["Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, 10032, New York, USA","Department of Pathology & Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, 10032, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Pathology & Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center New York USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073890226","https://openalex.org/A5100329533"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":6.3248,"has_fulltext":false,"cited_by_count":969,"citation_normalized_percentile":{"value":0.99,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"5","first_page":"284","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-dysregulation","display_name":"lipid dysregulation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8799999952316284},{"id":"https://openalex.org/keywords/amyloidogenesis","display_name":"amyloidogenesis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lipid-signaling","display_name":"lipid signaling","score":0.7440000176429749},{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.984000027179718},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8149999976158142},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.7304714918136597},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6185615062713623},{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.5436962246894836},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5033034682273865},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5018818378448486},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.4728448987007141},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.44135037064552307},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4336029291152954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3968486189842224},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32081839442253113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24749687314033508},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2031964361667633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12958189845085144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11219784617424011},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11104831099510193},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.10821220278739929},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nrn3012","doi":"https://doi.org/10.1038/nrn3012","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn3012","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:21448224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21448224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3321383","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3321383","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Rev Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3321383","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3321383","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Rev Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2091642752","display_name":null,"funder_award_id":"NS074536","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G217107320","display_name":null,"funder_award_id":"NS056049","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G251617455","display_name":"Validating a Novel Lipid Phosphatase Target in Alzheimer's Disease","funder_award_id":"R01NS074536","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3134141119","display_name":"Role of phosphoinositides in neuronal membrane traffic and neurodegeneration","funder_award_id":"R01NS056049","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4624438818","display_name":null,"funder_award_id":"AG033199","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6050439654","display_name":null,"funder_award_id":"R03 AG033212","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6226864637","display_name":null,"funder_award_id":"HD05547","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8093837728","display_name":null,"funder_award_id":"AG033212","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8118578649","display_name":null,"funder_award_id":"R21 AG033199","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8343067284","display_name":"Role of PIP2 metabolism imbalance in Down Syndrome","funder_award_id":"R01HD055457","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W35662498","https://openalex.org/W122681018","https://openalex.org/W1560871346","https://openalex.org/W1639168368","https://openalex.org/W1730584303","https://openalex.org/W1819221371","https://openalex.org/W1863182174","https://openalex.org/W1964049915","https://openalex.org/W1965050626","https://openalex.org/W1965637971","https://openalex.org/W1966452335","https://openalex.org/W1970055334","https://openalex.org/W1973272679","https://openalex.org/W1973516547","https://openalex.org/W1973932627","https://openalex.org/W1974040473","https://openalex.org/W1974394119","https://openalex.org/W1974724055","https://openalex.org/W1974823287","https://openalex.org/W1975783279","https://openalex.org/W1975806945","https://openalex.org/W1977949322","https://openalex.org/W1978464661","https://openalex.org/W1978479234","https://openalex.org/W1978835724","https://openalex.org/W1980750700","https://openalex.org/W1980825524","https://openalex.org/W1984542598","https://openalex.org/W1985623563","https://openalex.org/W1985871594","https://openalex.org/W1988904536","https://openalex.org/W1989076425","https://openalex.org/W1989089334","https://openalex.org/W1991166529","https://openalex.org/W1991366780","https://openalex.org/W1991717070","https://openalex.org/W1993465897","https://openalex.org/W1996838219","https://openalex.org/W1997942372","https://openalex.org/W1999607830","https://openalex.org/W2001454826","https://openalex.org/W2003742510","https://openalex.org/W2006166262","https://openalex.org/W2006534012","https://openalex.org/W2011637489","https://openalex.org/W2013382634","https://openalex.org/W2014204010","https://openalex.org/W2018342879","https://openalex.org/W2019593939","https://openalex.org/W2021148483","https://openalex.org/W2023125175","https://openalex.org/W2023133235","https://openalex.org/W2023229364","https://openalex.org/W2024372419","https://openalex.org/W2024517044","https://openalex.org/W2025289160","https://openalex.org/W2025888688","https://openalex.org/W2026931674","https://openalex.org/W2028195118","https://openalex.org/W2029040938","https://openalex.org/W2029352103","https://openalex.org/W2029377385","https://openalex.org/W2029593286","https://openalex.org/W2030025114","https://openalex.org/W2030581183","https://openalex.org/W2034286717","https://openalex.org/W2036362108","https://openalex.org/W2040137618","https://openalex.org/W2040252771","https://openalex.org/W2040912634","https://openalex.org/W2042130020","https://openalex.org/W2046952010","https://openalex.org/W2047442659","https://openalex.org/W2047599807","https://openalex.org/W2048210493","https://openalex.org/W2052555803","https://openalex.org/W2053378951","https://openalex.org/W2054615702","https://openalex.org/W2058930537","https://openalex.org/W2059672480","https://openalex.org/W2062034622","https://openalex.org/W2064032283","https://openalex.org/W2067772115","https://openalex.org/W2069121057","https://openalex.org/W2070596032","https://openalex.org/W2071003937","https://openalex.org/W2071113877","https://openalex.org/W2073700418","https://openalex.org/W2076021360","https://openalex.org/W2076474317","https://openalex.org/W2077805320","https://openalex.org/W2078917784","https://openalex.org/W2081431643","https://openalex.org/W2081980695","https://openalex.org/W2084820723","https://openalex.org/W2087661112","https://openalex.org/W2088426105","https://openalex.org/W2089189677","https://openalex.org/W2090545764","https://openalex.org/W2091665009","https://openalex.org/W2091782008","https://openalex.org/W2091884933","https://openalex.org/W2096012124","https://openalex.org/W2098186684","https://openalex.org/W2098460507","https://openalex.org/W2099556509","https://openalex.org/W2100026237","https://openalex.org/W2105632027","https://openalex.org/W2107288853","https://openalex.org/W2110855516","https://openalex.org/W2110961285","https://openalex.org/W2112336037","https://openalex.org/W2114145205","https://openalex.org/W2114229857","https://openalex.org/W2117067724","https://openalex.org/W2117141439","https://openalex.org/W2118265926","https://openalex.org/W2121825597","https://openalex.org/W2125872855","https://openalex.org/W2128401893","https://openalex.org/W2128479394","https://openalex.org/W2131180711","https://openalex.org/W2131581438","https://openalex.org/W2131746860","https://openalex.org/W2131819352","https://openalex.org/W2134422863","https://openalex.org/W2134970813","https://openalex.org/W2136558879","https://openalex.org/W2139296284","https://openalex.org/W2142215500","https://openalex.org/W2142555655","https://openalex.org/W2142632602","https://openalex.org/W2143830585","https://openalex.org/W2145653235","https://openalex.org/W2145785365","https://openalex.org/W2147268537","https://openalex.org/W2148918646","https://openalex.org/W2149733880","https://openalex.org/W2151049459","https://openalex.org/W2151091046","https://openalex.org/W2152119060","https://openalex.org/W2156182155","https://openalex.org/W2156542857","https://openalex.org/W2164868723","https://openalex.org/W2169555689","https://openalex.org/W2171187981","https://openalex.org/W2267120949","https://openalex.org/W2404116576","https://openalex.org/W3214092816"],"related_works":["https://openalex.org/W2323043713","https://openalex.org/W2050909509","https://openalex.org/W1990344203","https://openalex.org/W2091328185","https://openalex.org/W2071884435","https://openalex.org/W159178733","https://openalex.org/W2051535628","https://openalex.org/W1994887546","https://openalex.org/W4307526891","https://openalex.org/W2149056596"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":63},{"year":2025,"cited_by_count":64},{"year":2024,"cited_by_count":63},{"year":2023,"cited_by_count":64},{"year":2022,"cited_by_count":67},{"year":2021,"cited_by_count":60},{"year":2020,"cited_by_count":86},{"year":2019,"cited_by_count":72},{"year":2018,"cited_by_count":61},{"year":2017,"cited_by_count":73},{"year":2016,"cited_by_count":70},{"year":2015,"cited_by_count":49},{"year":2014,"cited_by_count":52},{"year":2013,"cited_by_count":68},{"year":2012,"cited_by_count":42}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
