{"id":"https://openalex.org/W1982958012","doi":"https://doi.org/10.1016/s1074-5521(00)00025-9","title":"Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription","display_name":"Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W1982958012","doi":"https://doi.org/10.1016/s1074-5521(00)00025-9","mag":"1982958012","pmid":"https://pubmed.ncbi.nlm.nih.gov/11033082"},"language":"en","primary_location":{"id":"doi:10.1016/s1074-5521(00)00025-9","doi":"https://doi.org/10.1016/s1074-5521(00)00025-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-5521(00)00025-9","pdf_url":"http://www.cell.com/article/S1074552100000259/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1074552100000259/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011350446","display_name":"Matthew P. Coghlan","orcid":"https://orcid.org/0000-0002-0894-1505","observed_orcids":["https://orcid.org/0000-0002-0894-1505"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Matthew P Coghlan","raw_affiliation_strings":["Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK. matthew_coghlan-1@sbphrd.com","Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Essex, UK. matthew_coghlan-1@sbphrd.com","institution_ids":[]},{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008924160","display_name":"Ainsley A. Culbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ainsley A Culbert","raw_affiliation_strings":["Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026352956","display_name":"Darren A.E. Cross","orcid":"https://orcid.org/0000-0002-5227-2871","observed_orcids":["https://orcid.org/0000-0002-5227-2871"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Darren AE Cross","raw_affiliation_strings":["Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045952504","display_name":"Stacey L. Corcoran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stacey L Corcoran","raw_affiliation_strings":["Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032843939","display_name":"John W. Yates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John W Yates","raw_affiliation_strings":["Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nigel J Pearce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel J Pearce","raw_affiliation_strings":["Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053939329","display_name":"Oliver Rausch","orcid":"https://orcid.org/0000-0003-4074-3848","observed_orcids":["https://orcid.org/0000-0003-4074-3848"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver L Rausch","raw_affiliation_strings":["Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gregory J Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gregory J Murphy","raw_affiliation_strings":["Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089858136","display_name":"Paul S. Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul S Carter","raw_affiliation_strings":["Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059738312","display_name":"Lynne Roxbee Cox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynne Roxbee Cox","raw_affiliation_strings":["Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101883867","display_name":"David E. Mills","orcid":"https://orcid.org/0000-0003-0188-7451","observed_orcids":["https://orcid.org/0000-0003-0188-7451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Mills","raw_affiliation_strings":["Department of Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031519165","display_name":"Murray J. B. Brown","orcid":"https://orcid.org/0000-0002-2393-7686","observed_orcids":["https://orcid.org/0000-0002-2393-7686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murray J Brown","raw_affiliation_strings":["Department of Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111753989","display_name":"David Haigh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Haigh","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010838021","display_name":"Robert W. Ward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert W Ward","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"David G Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G Smith","raw_affiliation_strings":["Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenneth J Murray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth J Murray","raw_affiliation_strings":["Department of Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324765","display_name":"Alastair D. Reith","orcid":"https://orcid.org/0000-0001-5092-0604","observed_orcids":["https://orcid.org/0000-0001-5092-0604"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alastair D Reith","raw_affiliation_strings":["Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108415722","display_name":"Julie C. Holder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie C Holder","raw_affiliation_strings":["Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AD, UK","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011350446"],"corresponding_institution_ids":["https://openalex.org/I188950975"],"apc_list":null,"apc_paid":null,"fwci":9.3486,"has_fulltext":false,"cited_by_count":897,"citation_normalized_percentile":{"value":0.98786124,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"10","first_page":"793","last_page":"803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gsk-3-inhibitors","display_name":"GSK-3 inhibitors","score":0.953000009059906},{"id":"https://openalex.org/keywords/sb216763","display_name":"SB216763","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gsk-3alpha","display_name":"GSK3\u03b1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycogen-metabolism","display_name":"glycogen metabolism","score":0.7839999794960022},{"id":"https://openalex.org/keywords/glycogen-synthase","display_name":"glycogen synthase","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.828000009059906},{"id":"https://openalex.org/keywords/atp-competitive-inhibition","display_name":"ATP-competitive inhibition","score":0.6650000214576721},{"id":"https://openalex.org/keywords/selective-kinase-inhibitors","display_name":"selective kinase inhibitors","score":0.5299999713897705},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.781000018119812},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.8694955110549927},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.725054144859314},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6507859230041504},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.6068393588066101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6017597317695618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5706285834312439},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46028533577919006},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4366551339626312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.423162579536438},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.417934387922287},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.41736286878585815},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3666236400604248}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000627","descriptor_name":"Aminophenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000627","descriptor_name":"Aminophenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000627","descriptor_name":"Aminophenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006006","descriptor_name":"Glycogen Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006006","descriptor_name":"Glycogen Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006006","descriptor_name":"Glycogen Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038341","descriptor_name":"Glycogen Synthase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s1074-5521(00)00025-9","doi":"https://doi.org/10.1016/s1074-5521(00)00025-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-5521(00)00025-9","pdf_url":"http://www.cell.com/article/S1074552100000259/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biology","raw_type":"journal-article"},{"id":"pmid:11033082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11033082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/4eff1268-4d14-4620-afef-c0b0ce5a0716","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/4eff1268-4d14-4620-afef-c0b0ce5a0716","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Coghlan, M P, Culbert, A A, Cross, D A E, Corcoran, S L, Yates, J W, Pearce, N J, Rausch, O L, Murphy, G J, Carter, P S, Cox, L R, Mills, D, Brown, M J, Haigh, D, Ward, R W, Smith, D G, Murray, K J, Reith, A D & Holder, J C 2000, 'Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription', Chemistry & Biology, vol. 7, no. 10, pp. 793-803.","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.7270/q2m32t0x","doi":"https://doi.org/10.7270/q2m32t0x","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2m32t0x","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1016/s1074-5521(00)00025-9","doi":"https://doi.org/10.1016/s1074-5521(00)00025-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-5521(00)00025-9","pdf_url":"http://www.cell.com/article/S1074552100000259/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry &amp; Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982958012.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W31347860","https://openalex.org/W97523097","https://openalex.org/W172080573","https://openalex.org/W1451690345","https://openalex.org/W1541093433","https://openalex.org/W1592353043","https://openalex.org/W1890393292","https://openalex.org/W1897439129","https://openalex.org/W1978046076","https://openalex.org/W1979993283","https://openalex.org/W1982342854","https://openalex.org/W1983055247","https://openalex.org/W1999756074","https://openalex.org/W2007961360","https://openalex.org/W2009445851","https://openalex.org/W2011596197","https://openalex.org/W2014085191","https://openalex.org/W2016135608","https://openalex.org/W2018539096","https://openalex.org/W2018926746","https://openalex.org/W2020059934","https://openalex.org/W2031102482","https://openalex.org/W2036864436","https://openalex.org/W2039550162","https://openalex.org/W2039842713","https://openalex.org/W2043330848","https://openalex.org/W2049875806","https://openalex.org/W2051788298","https://openalex.org/W2057327606","https://openalex.org/W2058138221","https://openalex.org/W2073292164","https://openalex.org/W2074077423","https://openalex.org/W2078680897","https://openalex.org/W2080372560","https://openalex.org/W2098017074","https://openalex.org/W2101361153","https://openalex.org/W2103232698","https://openalex.org/W2106303985","https://openalex.org/W2108302157","https://openalex.org/W2123180955","https://openalex.org/W2129662130","https://openalex.org/W2140664543","https://openalex.org/W2154342180","https://openalex.org/W2170537843","https://openalex.org/W2416516295","https://openalex.org/W2434896399","https://openalex.org/W2442275722","https://openalex.org/W2764869052","https://openalex.org/W4247904703"],"related_works":["https://openalex.org/W4248586904","https://openalex.org/W2318883589","https://openalex.org/W2401632846","https://openalex.org/W2019867611","https://openalex.org/W1831189467","https://openalex.org/W2099143291","https://openalex.org/W1601657500","https://openalex.org/W2366072566","https://openalex.org/W2032842127","https://openalex.org/W2135561672"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":46},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":38},{"year":2013,"cited_by_count":47},{"year":2012,"cited_by_count":36}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
