{"id":"https://openalex.org/W1982956353","doi":"https://doi.org/10.1021/jm061131z","title":"Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase \u03912\u03b1","display_name":"Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase \u03912\u03b1","publication_year":2007,"publication_date":"2007-02-17","ids":{"openalex":"https://openalex.org/W1982956353","doi":"https://doi.org/10.1021/jm061131z","mag":"1982956353","pmid":"https://pubmed.ncbi.nlm.nih.gov/17305324"},"language":"el","primary_location":{"id":"doi:10.1021/jm061131z","doi":"https://doi.org/10.1021/jm061131z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm061131z","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074365359","display_name":"Katherine L. Lee","orcid":"https://orcid.org/0000-0003-0155-290X","observed_orcids":["https://orcid.org/0000-0003-0155-290X"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine L. Lee","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110084640","display_name":"Megan A. Foley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan A. Foley","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045769885","display_name":"Lih-Ren Chen","orcid":"https://orcid.org/0000-0002-4819-3337","observed_orcids":["https://orcid.org/0000-0002-4819-3337","https://orcid.org/0000-0001-6582-9651"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihren Chen","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040823355","display_name":"Mark L. Behnke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Behnke","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041016509","display_name":"Frank Lovering","orcid":"https://orcid.org/0000-0002-9515-8200","observed_orcids":["https://orcid.org/0000-0002-9515-8200"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank E. Lovering","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074642311","display_name":"Steven J. Kirincich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Kirincich","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107378398","display_name":"Weiheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiheng Wang","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016835654","display_name":"Jaechul Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaechul Shim","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113728313","display_name":"Steve Tam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Tam","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064821705","display_name":"Marina W. H. Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina W. H. Shen","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112217571","display_name":"S P Khor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SooPeang Khor","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009440227","display_name":"Xin Xu","orcid":"https://orcid.org/0000-0002-5644-5397","observed_orcids":["https://orcid.org/0000-0002-5644-5397"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050267775","display_name":"Debra G. Goodwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra G. Goodwin","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041183323","display_name":"Manjunath K. Ramarao","orcid":"https://orcid.org/0000-0003-3698-6118","observed_orcids":["https://orcid.org/0000-0003-3698-6118"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manjunath K. Ramarao","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074638279","display_name":"Cheryl L. Nickerson\u2010Nutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Nickerson-Nutter","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035126803","display_name":"Frances Donahue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances Donahue","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Sherry Ku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sherry Ku","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037386752","display_name":"James D. Clark","orcid":"https://orcid.org/0000-0002-4801-0123","observed_orcids":["https://orcid.org/0000-0002-4801-0123"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Clark","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018433143","display_name":"John C. McKew","orcid":"https://orcid.org/0000-0003-0771-8114","observed_orcids":["https://orcid.org/0000-0003-0771-8114"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. McKew","raw_affiliation_strings":["Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140","institution_ids":["https://openalex.org/I4403928396"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074365359"],"corresponding_institution_ids":["https://openalex.org/I4403928396"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.219,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.96226342,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"50","issue":"6","first_page":"1380","last_page":"1400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytosolic-phospholipase-a2-alpha","display_name":"cytosolic phospholipase A2 alpha","score":0.9279999732971191},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sulfonamide-analogues","display_name":"sulfonamide analogues","score":0.8199999928474426},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5680000185966492},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.902999997138977},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.8100000023841858},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.824999988079071},{"id":"https://openalex.org/keywords/air-pouch-model","display_name":"air pouch model","score":0.6980000138282776},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8677976131439209},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.6658698320388794},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.6610156893730164},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.5998122692108154},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.5360280275344849},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.5343161225318909},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5161648392677307},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4626205265522003},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.4546350836753845},{"id":"https://openalex.org/C2776888444","wikidata":"https://www.wikidata.org/wiki/Q7187515","display_name":"Phospholipase A","level":4,"score":0.4288646876811981},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4283744692802429},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.41900312900543213},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.415671169757843},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.41488727927207947},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.387067973613739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35563305020332336},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3495553135871887},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.31813645362854004},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30739519000053406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2061871588230133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11334982514381409}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054513","descriptor_name":"Group IV Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm061131z","doi":"https://doi.org/10.1021/jm061131z","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm061131z","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:17305324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17305324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1483780845","https://openalex.org/W1485999476","https://openalex.org/W1530740124","https://openalex.org/W1544502281","https://openalex.org/W1548326540","https://openalex.org/W1578975528","https://openalex.org/W1598451699","https://openalex.org/W1964597788","https://openalex.org/W1966871759","https://openalex.org/W1967713105","https://openalex.org/W1969442004","https://openalex.org/W1971097590","https://openalex.org/W1972482097","https://openalex.org/W1975316500","https://openalex.org/W1979844089","https://openalex.org/W1981819970","https://openalex.org/W1997364548","https://openalex.org/W2007109726","https://openalex.org/W2008893973","https://openalex.org/W2011368907","https://openalex.org/W2015728419","https://openalex.org/W2028586486","https://openalex.org/W2040040765","https://openalex.org/W2041622964","https://openalex.org/W2051686420","https://openalex.org/W2053983148","https://openalex.org/W2054478199","https://openalex.org/W2056509528","https://openalex.org/W2057547095","https://openalex.org/W2061719956","https://openalex.org/W2063877848","https://openalex.org/W2081354216","https://openalex.org/W2081658797","https://openalex.org/W2084089231","https://openalex.org/W2092320644","https://openalex.org/W2102368544","https://openalex.org/W2112146951","https://openalex.org/W2121247398","https://openalex.org/W2128680329","https://openalex.org/W2130098255","https://openalex.org/W2133372513","https://openalex.org/W2140179741","https://openalex.org/W2151792779","https://openalex.org/W2157674060","https://openalex.org/W2160163478","https://openalex.org/W2316863919","https://openalex.org/W2328831875","https://openalex.org/W2626800913","https://openalex.org/W2951377589","https://openalex.org/W2953021019","https://openalex.org/W3109096340","https://openalex.org/W4232987820"],"related_works":["https://openalex.org/W2076625854","https://openalex.org/W2036435702","https://openalex.org/W1966409656","https://openalex.org/W2053983148","https://openalex.org/W1967713105","https://openalex.org/W2130958227","https://openalex.org/W2150449501","https://openalex.org/W1982994949","https://openalex.org/W1976894905","https://openalex.org/W4236151877"],"abstract_inverted_index":{"The":[0,45],"synthesis":[1],"and":[2,37,43,63,85,101],"structure-activity":[3],"relationship":[4],"of":[5,8,11,22,39,47,60,66,79],"a":[6,48,76],"series":[7],"indole":[9],"inhibitors":[10],"cytosolic":[12],"phospholipase":[13],"A2alpha":[14],"(cPLA2alpha,":[15],"type":[16],"IVA":[17],"phospholipase)":[18],"are":[19,24],"described.":[20],"Inhibitors":[21],"cPLA2alpha":[23,80],"predicted":[25],"to":[26,56],"be":[27],"efficacious":[28],"in":[29,81,95],"treating":[30],"asthma":[31],"as":[32,34],"well":[33],"the":[35,64,82,96],"signs":[36],"symptoms":[38],"osteoarthritis,":[40],"rheumatoid":[41],"arthritis,":[42],"pain.":[44],"introduction":[46],"benzyl":[49],"sulfonamide":[50,68],"substituent":[51],"at":[52],"C2":[53],"was":[54],"found":[55],"impart":[57],"improved":[58],"potency":[59],"these":[61,67],"inhibitors,":[62],"SAR":[65],"analogues":[69],"is":[70,75],"disclosed.":[71],"Compound":[72,90],"123":[73,91],"(Ecopladib)":[74],"sub-micromolar":[77],"inhibitor":[78],"GLU":[83],"micelle":[84],"rat":[86,97,102],"whole":[87],"blood":[88],"assays.":[89],"displayed":[92],"oral":[93],"efficacy":[94],"carrageenan":[98],"air":[99],"pouch":[100],"carrageenan-induced":[103],"paw":[104],"edema":[105],"models.":[106]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
