{"id":"https://openalex.org/W1982955486","doi":"https://doi.org/10.4161/hv.21382","title":"Challenges in the development of an autologous heat shock protein based anti-tumor vaccine","display_name":"Challenges in the development of an autologous heat shock protein based anti-tumor vaccine","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W1982955486","doi":"https://doi.org/10.4161/hv.21382","mag":"1982955486","pmid":"https://pubmed.ncbi.nlm.nih.gov/22854658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3551892"},"language":"en","primary_location":{"id":"doi:10.4161/hv.21382","doi":"https://doi.org/10.4161/hv.21382","is_oa":true,"landing_page_url":"https://doi.org/10.4161/hv.21382","pdf_url":null,"source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines & Immunotherapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4161/hv.21382","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967187","display_name":"Dirk J. Reitsma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296342797","display_name":"Pharmaceutical Product Development (United States)","ror":"https://ror.org/01sjx9496","country_code":"US","type":"company","lineage":["https://openalex.org/I1296342797"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dirk J. Reitsma","raw_affiliation_strings":["PPD; Wilmington, NC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PPD; Wilmington, NC USA","institution_ids":["https://openalex.org/I1296342797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032815852","display_name":"Austin James Combest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1296342797","display_name":"Pharmaceutical Product Development (United States)","ror":"https://ror.org/01sjx9496","country_code":"US","type":"company","lineage":["https://openalex.org/I1296342797"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin J. Combest","raw_affiliation_strings":["PPD; Wilmington, NC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PPD; Wilmington, NC USA","institution_ids":["https://openalex.org/I1296342797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110967187"],"corresponding_institution_ids":["https://openalex.org/I1296342797"],"apc_list":{"value":2895,"currency":"EUR","value_usd":3175},"apc_paid":{"value":2895,"currency":"EUR","value_usd":3175},"fwci":0.3407,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.30600522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"8","first_page":"1152","last_page":"1155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.22450000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.7739999890327454},{"id":"https://openalex.org/keywords/autologous-vaccine","display_name":"autologous vaccine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.871999979019165},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.5580000281333923},{"id":"https://openalex.org/keywords/vaccine-development-challenges","display_name":"vaccine development challenges","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6494750380516052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5004312992095947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4712403416633606},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4152320325374603},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39190515875816345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27169379591941833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10040387511253357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/hv.21382","doi":"https://doi.org/10.4161/hv.21382","is_oa":true,"landing_page_url":"https://doi.org/10.4161/hv.21382","pdf_url":null,"source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines & Immunotherapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3551892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3551892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Vaccin Immunother","raw_type":"Text"},{"id":"pmid:22854658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22854658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human vaccines & immunotherapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8a3e413cb7a04f94bc21cd4610451159","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8a3e413cb7a04f94bc21cd4610451159","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Vaccines & Immunotherapeutics, Vol 8, Iss 8, Pp 1152-1155 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4161/hv.21382","doi":"https://doi.org/10.4161/hv.21382","is_oa":true,"landing_page_url":"https://doi.org/10.4161/hv.21382","pdf_url":null,"source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines & Immunotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1828940258","https://openalex.org/W1950572133","https://openalex.org/W1969525589","https://openalex.org/W1974498683","https://openalex.org/W2001131198","https://openalex.org/W2001230274","https://openalex.org/W2001679453","https://openalex.org/W2003278673","https://openalex.org/W2005494948","https://openalex.org/W2005895632","https://openalex.org/W2006875259","https://openalex.org/W2037299442","https://openalex.org/W2048800818","https://openalex.org/W2050101449","https://openalex.org/W2077006408","https://openalex.org/W2080335579","https://openalex.org/W2090013658","https://openalex.org/W2091193892","https://openalex.org/W2094520873","https://openalex.org/W2095927984","https://openalex.org/W2097995306","https://openalex.org/W2099289479","https://openalex.org/W2103959341","https://openalex.org/W2108348820","https://openalex.org/W2114300639","https://openalex.org/W2114641400","https://openalex.org/W2123914905","https://openalex.org/W2129134252","https://openalex.org/W2140690632","https://openalex.org/W2140715248","https://openalex.org/W2149752186","https://openalex.org/W2160143217","https://openalex.org/W2165222076","https://openalex.org/W2245367447","https://openalex.org/W2417585790","https://openalex.org/W2470660931","https://openalex.org/W2582877258"],"related_works":["https://openalex.org/W2601894304","https://openalex.org/W2010361286","https://openalex.org/W2080335579","https://openalex.org/W2036176868","https://openalex.org/W2595708677","https://openalex.org/W2085095621","https://openalex.org/W2411284627","https://openalex.org/W2207987456","https://openalex.org/W2083602522","https://openalex.org/W1977188362"],"abstract_inverted_index":{"In":[0],"spite":[1],"of":[2,7],"its":[3],"long":[4],"history,":[5],"immunotherapy":[6],"cancer":[8,24],"has":[9],"led":[10],"to":[11],"only":[12],"a":[13],"few":[14],"regulatory":[15],"approved":[16],"treatments,":[17],"starting":[18],"with":[19],"interleukin":[20],"(IL)-2":[21],"in":[22,29],"renal":[23],"and":[25,27],"melanoma":[26],"interferon":[28],"melanoma....":[30]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}