{"id":"https://openalex.org/W1982947499","doi":"https://doi.org/10.1163/1568569053421762","title":"Antibacterial effect of bupivacaine and ropivacaine; effect of adjuvant drugs","display_name":"Antibacterial effect of bupivacaine and ropivacaine; effect of adjuvant drugs","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W1982947499","doi":"https://doi.org/10.1163/1568569053421762","mag":"1982947499"},"language":"fr","primary_location":{"id":"doi:10.1163/1568569053421762","doi":"https://doi.org/10.1163/1568569053421762","is_oa":false,"landing_page_url":"https://doi.org/10.1163/1568569053421762","pdf_url":null,"source":{"id":"https://openalex.org/S52047856","display_name":"The Pain Clinic","issn_l":"0169-1112","issn":["0169-1112","1568-5691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pain Clinic","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1982947499"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080674045","display_name":"L\u00fctfiye Pirbudak","orcid":"https://orcid.org/0000-0002-3474-1056","observed_orcids":["https://orcid.org/0000-0002-3474-1056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00fctfiye Pirbudak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083856000","display_name":"Tekin Karsl\u0131\u011fil","orcid":"https://orcid.org/0000-0001-7672-3625","observed_orcids":["https://orcid.org/0000-0001-7672-3625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tekin Karsligil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053060893","display_name":"Yasemin Zer","orcid":"https://orcid.org/0000-0002-9078-9900","observed_orcids":["https://orcid.org/0000-0002-9078-9900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasemin Zer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\u00dcnsal \u00d6ner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00dcnsal \u00d6ner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110071549","display_name":"\u0130clal Balc\u0131","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iclal Balci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7673,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72509619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"1","first_page":"73","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.10670000314712524,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.07819999754428864,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bupivacaine","display_name":"bupivacaine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ropivacaine","display_name":"ropivacaine","score":1.0},{"id":"https://openalex.org/keywords/local-anesthetics","display_name":"local anesthetics","score":0.7900000214576721},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/adjuvant-drugs","display_name":"adjuvant drugs","score":0.828000009059906},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.6110000014305115},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.9769999980926514},{"id":"https://openalex.org/keywords/meperidine","display_name":"pethidine","score":0.8899999856948853},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.8450000286102295},{"id":"https://openalex.org/keywords/midazolam","display_name":"midazolam","score":0.8579999804496765},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.609000027179718},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.968999981880188},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9390000104904175},{"id":"https://openalex.org/keywords/proteus","display_name":"Proteus","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2780269707","wikidata":"https://www.wikidata.org/wiki/Q279504","display_name":"Ropivacaine","level":2,"score":0.8451859951019287},{"id":"https://openalex.org/C2781328992","wikidata":"https://www.wikidata.org/wiki/Q422806","display_name":"Bupivacaine","level":2,"score":0.7871101498603821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7081437706947327},{"id":"https://openalex.org/C2777949923","wikidata":"https://www.wikidata.org/wiki/Q131915","display_name":"Staphylococcus epidermidis","level":4,"score":0.5715830326080322},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.5329647064208984},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5015246868133545},{"id":"https://openalex.org/C2780662933","wikidata":"https://www.wikidata.org/wiki/Q2701588","display_name":"Proteus vulgaris","level":4,"score":0.43242311477661133},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4228639602661133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41704633831977844},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3572022020816803},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33216190338134766},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2162146270275116},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.20710474252700806},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17160603404045105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0867677628993988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1163/1568569053421762","doi":"https://doi.org/10.1163/1568569053421762","is_oa":false,"landing_page_url":"https://doi.org/10.1163/1568569053421762","pdf_url":null,"source":{"id":"https://openalex.org/S52047856","display_name":"The Pain Clinic","issn_l":"0169-1112","issn":["0169-1112","1568-5691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Pain Clinic","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1979944856","https://openalex.org/W2007467255","https://openalex.org/W2015880630","https://openalex.org/W2042998415","https://openalex.org/W2049666615","https://openalex.org/W2054079326","https://openalex.org/W2061444266","https://openalex.org/W2072531749","https://openalex.org/W2079830901","https://openalex.org/W2092465520","https://openalex.org/W2102244219","https://openalex.org/W2104570804","https://openalex.org/W2108357217","https://openalex.org/W2152079749","https://openalex.org/W2170911054","https://openalex.org/W2401339137","https://openalex.org/W2411814434","https://openalex.org/W4243768129"],"related_works":["https://openalex.org/W2092465520","https://openalex.org/W2079830901","https://openalex.org/W4402197602","https://openalex.org/W2755213289","https://openalex.org/W2967469519","https://openalex.org/W1834591633","https://openalex.org/W2593719888","https://openalex.org/W2015296488","https://openalex.org/W2047965389","https://openalex.org/W2077010527"],"abstract_inverted_index":{"Background:":[0],"In":[1],"this":[2],"study,":[3],"we":[4],"assessed":[5],"the":[6,13,19,33,37,44,48,86,154,161,167,217,256,260],"effect":[7,232],"of":[8,21,36,47,85,132,148,153,163,169,216,233,239,259],"bupivacaine":[9,102,128,170,226,240],"and":[10,30,79,98,103,122,138,183,191,198,204,206,224,251],"ropivacaine":[11,104,144,197,205,223,234],"on":[12,32],"bacterial":[14],"growth":[15],"as":[16,18],"well":[17],"impact":[20],"adjuvant":[22,155,245],"drugs":[23,246],"(morphine,":[24],"meperidine,":[25],"fentanyl,":[26],"ketamine,":[27],"clonidine,":[28],"tramadol":[29],"midazolam)":[31],"antibacterial":[34,158],"activity":[35,159,250],"local":[38,49,87,164,261],"anesthetics.":[39,165,262],"Methods:":[40],"Using":[41],"microdilution":[42],"technique,":[43],"antimicrobial":[45,231,249,257],"effects":[46,258],"anesthetics":[50],"were":[51,72,92,105,125,141,212],"tested":[52],"against":[53,181,214],"135":[54],"bacteria":[55,71],"(Escherichia":[56],"coli,":[57,109],"Pseudomonas":[58],"aeruginosa,":[59,113],"Staphylococcus":[60,62,115,119],"aureus,":[61],"epidermidis,":[63],"Klebsiella":[64],"pneumoniae,":[65,111],"Proteus":[66,123,139],"spp.,":[67],"Enterococcus":[68],"spp.).":[69],"The":[70,230,244],"standardized":[73],"according":[74],"to":[75,81,95,127,143],"0.5":[76],"McFarland":[77],"units,":[78],"added":[80,94],"serial":[82],"diluted":[83],"solutions":[84,97],"anaesthetics.":[88],"Adjuvant":[89],"anaesthetic":[90],"materials":[91,156],"also":[93],"these":[96],"their":[99],"interactions":[100],"with":[101,174],"assessed.":[106],"Results:":[107],"E.":[108,218],"Kl.":[110,184],"P.":[112],"methisillin-sensitive":[114,118],"aureus":[116],"(MSSA),":[117],"epidermis":[120],"(MSSE)":[121],"species":[124,140],"sensitive":[126,142],"at":[129,145],"a":[130,146],"concentration":[131,147],"5":[133,188],"mg":[134,150,172,177,189,194,201,209],"ml\u22121.":[135,151],"MSSA,":[136],"MSSE":[137],"7.5":[149],"None":[152],"demonstrated":[157],"in":[160],"absence":[162],"But,":[166],"combination":[168,211],"(5":[171],"ml\u22121)":[173],"ketamine":[175,207],"15":[176,208],"ml\u22121":[178,190,195,202,210],"was":[179],"effective":[180,213],"MSSA":[182],"pneumoniae":[185],"species.":[186,220],"Bupivacaine":[187],"fentanyl":[192],"3":[193],"combination,":[196,203],"meperidine":[199],"12.5":[200],"one":[215],"coli":[219],"Conclusion:":[221],"0.75%":[222],"0.5%":[225],"have":[227,247],"anti-bacterial":[228],"effects.":[229],"is":[235],"less":[236],"than":[237],"that":[238],"by":[241],"approximately":[242],"50%.":[243],"no":[248],"they":[252],"do":[253],"not":[254],"potentiate":[255],"summary":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}