{"id":"https://openalex.org/W1982946753","doi":"https://doi.org/10.1073/pnas.84.14.4910","title":"Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells.","display_name":"Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells.","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W1982946753","doi":"https://doi.org/10.1073/pnas.84.14.4910","mag":"1982946753","pmid":"https://pubmed.ncbi.nlm.nih.gov/3474634","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/305216"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.84.14.4910","doi":"https://doi.org/10.1073/pnas.84.14.4910","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.84.14.4910","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1982946753"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC305216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015481514","display_name":"Katherine Luby\u2010Phelps","orcid":"https://orcid.org/0000-0002-8378-1409","observed_orcids":["https://orcid.org/0000-0002-8378-1409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Luby-Phelps","raw_affiliation_strings":["Cell Biology - Live Cell Imaging Core Facility"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology - Live Cell Imaging Core Facility","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089725348","display_name":"P E Castle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Castle","raw_affiliation_strings":["Epidemiology & Population Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology & Population Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101682555","display_name":"D. Lansing Taylor","orcid":"https://orcid.org/0000-0001-6947-1343","observed_orcids":["https://orcid.org/0000-0001-6947-1343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D L Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001270257","display_name":"Frederick Lanni","orcid":"https://orcid.org/0000-0002-7720-3346","observed_orcids":["https://orcid.org/0000-0002-7720-3346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Lanni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7459,"has_fulltext":false,"cited_by_count":399,"citation_normalized_percentile":{"value":0.96969697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"84","issue":"14","first_page":"4910","last_page":"4913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13675","display_name":"Diffusion Coefficients in Liquids","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13675","display_name":"Diffusion Coefficients in Liquids","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10288","display_name":"Fractional Differential Equations Solutions","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytoplasmic-diffusion","display_name":"cytoplasmic diffusion","score":0.921999990940094},{"id":"https://openalex.org/keywords/hindered-diffusion","display_name":"hindered diffusion","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ficoll","display_name":"Ficoll","score":0.7549999952316284},{"id":"https://openalex.org/keywords/size-dependent-diffusion","display_name":"size-dependent diffusion","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cytoplasmic-viscosity","display_name":"cytoplasmic viscosity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cytoplasmic-structure","display_name":"cytoplasmic structure","score":0.8460000157356262},{"id":"https://openalex.org/keywords/protein-solutions","display_name":"protein solutions","score":0.453000009059906},{"id":"https://openalex.org/keywords/3t3-cells","display_name":"3T3 fibroblasts","score":0.6970000267028809},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.6489999890327454},{"id":"https://openalex.org/keywords/polysomes","display_name":"polysomes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/multienzyme-complex","display_name":"multienzyme complex","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.9327878355979919},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6672433614730835},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.6205915212631226},{"id":"https://openalex.org/C181990884","wikidata":"https://www.wikidata.org/wiki/Q11396092","display_name":"Macromolecular crowding","level":3,"score":0.5921183228492737},{"id":"https://openalex.org/C5362183","wikidata":"https://www.wikidata.org/wiki/Q410200","display_name":"Ficoll","level":4,"score":0.5257059931755066},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5140310525894165},{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.48496365547180176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.467695951461792},{"id":"https://openalex.org/C2778015030","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Fluorescein","level":3,"score":0.45497676730155945},{"id":"https://openalex.org/C31332276","wikidata":"https://www.wikidata.org/wiki/Q899750","display_name":"Photobleaching","level":3,"score":0.425537645816803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3485383987426758},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.33646562695503235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3023446202278137},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.28694427013397217},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25326770544052124},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.22707810997962952},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.13639438152313232},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0738629400730133},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D005362","descriptor_name":"Ficoll","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.84.14.4910","doi":"https://doi.org/10.1073/pnas.84.14.4910","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.84.14.4910","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1459533","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC305216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:3474634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3474634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:305216","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC305216/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1459533","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC305216","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1585474337","display_name":null,"funder_award_id":"GM34639-02","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G635100408","display_name":"STRUCTURAL AND CHEMICAL DYNAMICS OF CELL MOVEMENT","funder_award_id":"5r01am032461-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W588400389","https://openalex.org/W1530935295","https://openalex.org/W1592581241","https://openalex.org/W1662742616","https://openalex.org/W1812451129","https://openalex.org/W1965606476","https://openalex.org/W1980983550","https://openalex.org/W1994537832","https://openalex.org/W2005101090","https://openalex.org/W2006259279","https://openalex.org/W2006685535","https://openalex.org/W2017934591","https://openalex.org/W2021152256","https://openalex.org/W2025925175","https://openalex.org/W2034728705","https://openalex.org/W2040004060","https://openalex.org/W2046645183","https://openalex.org/W2049930593","https://openalex.org/W2057939632","https://openalex.org/W2061123294","https://openalex.org/W2069883384","https://openalex.org/W2073164406","https://openalex.org/W2077534424","https://openalex.org/W2078652035","https://openalex.org/W2082871367","https://openalex.org/W2097246107","https://openalex.org/W2113092217","https://openalex.org/W2116403121","https://openalex.org/W2415517196"],"related_works":["https://openalex.org/W1979799065","https://openalex.org/W2071406071","https://openalex.org/W2809917228","https://openalex.org/W2128341772","https://openalex.org/W6925145709","https://openalex.org/W1989998882","https://openalex.org/W7125530670","https://openalex.org/W1965606476","https://openalex.org/W2026878536","https://openalex.org/W2113092217"],"abstract_inverted_index":{"Using":[0],"fluorescence":[1],"recovery":[2],"after":[3],"photobleaching,":[4],"we":[5,107],"have":[6],"studied":[7],"the":[8,15,27,40,63,79,94,118,184],"diffusion":[9,49,84],"of":[10,18,26,31,42,50,62,85,90,120,132,171],"fluorescein-labeled,":[11,46],"size-fractionated":[12,47],"Ficoll":[13,86],"in":[14,53,57,72,78,87,102,139],"cytoplasmic":[16,80,155,172],"space":[17],"living":[19],"Swiss":[20],"3T3":[21],"cells":[22],"as":[23,167,174],"a":[24,58,103,169],"probe":[25],"physical":[28,114],"chemical":[29,115],"properties":[30],"cytoplasm.":[32],"The":[33],"results":[34,41,123,149],"reported":[35,96],"here":[36],"corroborate":[37],"and":[38,183],"extend":[39],"earlier":[43],"experiments":[44],"with":[45],"dextran:":[48],"nonbinding":[51],"particles":[52,67,156],"cytoplasm":[54,98,128],"is":[55,99],"hindered":[56,101],"size-dependent":[59,104],"manner.":[60,105],"Extrapolation":[61],"data":[64],"suggests":[65],"that":[66,127],"larger":[68,185],"than":[69],"260":[70,162],"A":[71],"radius":[73],"may":[74,165],"be":[75,166],"completely":[76],"nondiffusible":[77],"space.":[81],"In":[82],"contrast,":[83],"protein":[88,142],"solutions":[89],"concentration":[91],"comparable":[92],"to":[93],"range":[95],"for":[97,117,153],"not":[100,137],"Although":[106],"cannot":[108],"at":[109,145],"present":[110],"distinguish":[111],"among":[112],"several":[113],"models":[116],"organization":[119],"cytoplasm,":[121],"these":[122],"make":[124],"it":[125],"clear":[126],"possesses":[129],"some":[130],"sort":[131],"higher-order":[133],"intermolecular":[134],"interactions":[135],"(structure)":[136],"found":[138],"simple":[140],"aqueous":[141],"solutions,":[143],"even":[144],"high":[146],"concentration.":[147],"These":[148],"also":[150],"suggest":[151],"that,":[152],"native":[154],"whose":[157],"smallest":[158],"radial":[159],"dimension":[160],"approaches":[161],"A,":[163],"size":[164],"important":[168],"determinant":[170],"diffusibility":[173],"binding":[175],"specificity.":[176],"This":[177],"would":[178],"include":[179],"most":[180],"endosomes,":[181],"polyribosomes,":[182],"multienzyme":[186],"complexes.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
