{"id":"https://openalex.org/W1982942144","doi":"https://doi.org/10.1016/s0145-2126(99)00106-x","title":"Hypophosphorylation of pRB and repression of cyclin D3 and cdc25A during the granulocytic differentiation of human myeloblastic leukemia ML-1 cells","display_name":"Hypophosphorylation of pRB and repression of cyclin D3 and cdc25A during the granulocytic differentiation of human myeloblastic leukemia ML-1 cells","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W1982942144","doi":"https://doi.org/10.1016/s0145-2126(99)00106-x","mag":"1982942144","pmid":"https://pubmed.ncbi.nlm.nih.gov/10573135"},"language":"en","primary_location":{"id":"doi:10.1016/s0145-2126(99)00106-x","doi":"https://doi.org/10.1016/s0145-2126(99)00106-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0145-2126(99)00106-x","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110015560","display_name":"Takahisa Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Shimizu","raw_affiliation_strings":["Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112642185","display_name":"Yuichi Oka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Oka","raw_affiliation_strings":["Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006154961","display_name":"Nao Awai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nao Awai","raw_affiliation_strings":["Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055554576","display_name":"Ken Takeda","orcid":"https://orcid.org/0000-0002-2906-5575","observed_orcids":["https://orcid.org/0000-0002-2906-5575"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Takeda","raw_affiliation_strings":["Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara-Machi, Shinjuku-ku, Tokyo 162-0826, Japan","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161296585"],"apc_list":{"value":3910,"currency":"USD","value_usd":3910},"apc_paid":null,"fwci":0.2873,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.44814655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"10","first_page":"901","last_page":"907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8989999890327454},{"id":"https://openalex.org/keywords/prb-hypophosphorylation","display_name":"pRb hypophosphorylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/cyclin-d3","display_name":"cyclin D3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cdc25a","display_name":"CDC25A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/myeloblastic-leukemia","display_name":"myeloblastic leukemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ml-1-cells","display_name":"ML-1 cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2777228722","wikidata":"https://www.wikidata.org/wiki/Q17859723","display_name":"CDC25A","level":5,"score":0.7621670961380005},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5259323716163635},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5189497470855713},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5178137421607971},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.484855055809021},{"id":"https://openalex.org/C2779378344","wikidata":"https://www.wikidata.org/wiki/Q264118","display_name":"Acute myeloblastic leukemia","level":3,"score":0.4768216013908386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47189268469810486},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.4619351625442505},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4588291347026825},{"id":"https://openalex.org/C2780733254","wikidata":"https://www.wikidata.org/wiki/Q5198271","display_name":"Cyclin D2","level":5,"score":0.4314620792865753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4055207073688507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3595038056373596},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3010651767253876},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.27049997448921204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23248451948165894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16443610191345215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1302279531955719},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12093916535377502}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020687","descriptor_name":"cdc25 Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020687","descriptor_name":"cdc25 Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056743","descriptor_name":"Cyclin D3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0145-2126(99)00106-x","doi":"https://doi.org/10.1016/s0145-2126(99)00106-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0145-2126(99)00106-x","pdf_url":null,"source":{"id":"https://openalex.org/S136942575","display_name":"Leukemia Research","issn_l":"0145-2126","issn":["0145-2126","1873-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia Research","raw_type":"journal-article"},{"id":"pmid:10573135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10573135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W120931273","https://openalex.org/W1554600230","https://openalex.org/W1721562336","https://openalex.org/W1871474857","https://openalex.org/W1928725833","https://openalex.org/W1965931378","https://openalex.org/W1979637520","https://openalex.org/W1981391513","https://openalex.org/W1992251869","https://openalex.org/W2013554303","https://openalex.org/W2017599618","https://openalex.org/W2022502588","https://openalex.org/W2050428831","https://openalex.org/W2051541258","https://openalex.org/W2058690254","https://openalex.org/W2063367127","https://openalex.org/W2075813138","https://openalex.org/W2091298934","https://openalex.org/W2091922265","https://openalex.org/W2092543937","https://openalex.org/W2105559291","https://openalex.org/W2129358281","https://openalex.org/W2141083396","https://openalex.org/W2145295538","https://openalex.org/W2152432521","https://openalex.org/W2184302823","https://openalex.org/W2256214571","https://openalex.org/W2324271478","https://openalex.org/W2399217009","https://openalex.org/W2407345634","https://openalex.org/W2419538121","https://openalex.org/W2421330132","https://openalex.org/W2476227533","https://openalex.org/W6645812490","https://openalex.org/W6712591574"],"related_works":["https://openalex.org/W1980865981","https://openalex.org/W2118657657","https://openalex.org/W2318278358","https://openalex.org/W1973079716","https://openalex.org/W2010083101","https://openalex.org/W2060560241","https://openalex.org/W2569035615","https://openalex.org/W1871474857","https://openalex.org/W2589740359","https://openalex.org/W2165104801"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}