{"id":"https://openalex.org/W1982938288","doi":"https://doi.org/10.1620/tjem.211.387","title":"Plasma Interleukin-8 as a Potential Predictor of Mortality in Adult Patients with Severe Traumatic Brain Injury","display_name":"Plasma Interleukin-8 as a Potential Predictor of Mortality in Adult Patients with Severe Traumatic Brain Injury","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1982938288","doi":"https://doi.org/10.1620/tjem.211.387","mag":"1982938288","pmid":"https://pubmed.ncbi.nlm.nih.gov/17409679"},"language":"en","primary_location":{"id":"doi:10.1620/tjem.211.387","doi":"https://doi.org/10.1620/tjem.211.387","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.211.387","pdf_url":"https://www.jstage.jst.go.jp/article/tjem/211/4/211_4_387/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tjem/211/4/211_4_387/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045325791","display_name":"Aleksandar Gop\u010devi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Aleksandar Gopcevic","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice","Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice","institution_ids":["https://openalex.org/I4210123681"]},{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice, Zagreb, Croatia","institution_ids":["https://openalex.org/I4210123681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090744885","display_name":"Branka Mazul\u2010Sunko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Branka Mazul-Sunko","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice","institution_ids":["https://openalex.org/I4210123681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087592290","display_name":"Jasminka Marout","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Jasminka Marout","raw_affiliation_strings":["Laboratory of Endocrinology, University Hospital Sestre Milosrdnice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Endocrinology, University Hospital Sestre Milosrdnice","institution_ids":["https://openalex.org/I4210123681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053051137","display_name":"Ante Sekuli\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ante Sekulic","raw_affiliation_strings":["University Department of Anesthesiology, Zagreb, Division of Neuroanesthesia and Neurointensive Care, University Hospital Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Anesthesiology, Zagreb, Division of Neuroanesthesia and Neurointensive Care, University Hospital Zagreb","institution_ids":["https://openalex.org/I138937732","https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047969911","display_name":"Nata\u0161a Antoljak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natasa Antoljak","raw_affiliation_strings":["Institute of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Public Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034142781","display_name":"Mladen \u0160iranovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Mladen Siranovic","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice","institution_ids":["https://openalex.org/I4210123681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048543429","display_name":"\u017deljko Ivanec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Zeljko Ivanec","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, University Hospital Sestre Milosrdnice","institution_ids":["https://openalex.org/I4210123681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089184209","display_name":"Marko Margaritoni","orcid":"https://orcid.org/0000-0003-2011-8973","observed_orcids":["https://orcid.org/0000-0003-2011-8973"]},"institutions":[{"id":"https://openalex.org/I180629606","display_name":"University of Dubrovnik","ror":"https://ror.org/05yptqp13","country_code":"HR","type":"education","lineage":["https://openalex.org/I180629606"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Marko Margaritoni","raw_affiliation_strings":["General Hospital, University of Dubrovnik"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hospital, University of Dubrovnik","institution_ids":["https://openalex.org/I180629606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070405758","display_name":"Miroslav Bekavac\u2010Beslin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123681","display_name":"Sisters of Charity Hospital","ror":"https://ror.org/024a8dx81","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210123681"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Miroslav Bekavac-Beslin","raw_affiliation_strings":["Department of Surgery, University Hospital Sestre Milosrdnice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Hospital Sestre Milosrdnice","institution_ids":["https://openalex.org/I4210123681"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012374133","display_name":"Neven \u017darkovi\u0107","orcid":"https://orcid.org/0000-0001-5032-0369","observed_orcids":["https://orcid.org/0000-0001-5032-0369"]},"institutions":[{"id":"https://openalex.org/I4210123216","display_name":"Ru\u0111er Bo\u0161kovi\u0107 Institute","ror":"https://ror.org/02mw21745","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210123216"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Neven Zarkovic","raw_affiliation_strings":["Department of Molecular Medicine, Rudjer Boskovic Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Rudjer Boskovic Institute","institution_ids":["https://openalex.org/I4210123216"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4643,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.87982188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"211","issue":"4","first_page":"387","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11467","display_name":"Trauma and Emergency Care Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9980000257492065},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.968999981880188},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apache-ii","display_name":"APACHE II score","score":0.843999981880188},{"id":"https://openalex.org/keywords/glasgow-coma-scale","display_name":"Glasgow Coma Scale","score":0.9929999709129333},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8577219247817993},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8033076524734497},{"id":"https://openalex.org/C17624336","wikidata":"https://www.wikidata.org/wiki/Q461644","display_name":"Glasgow Coma Scale","level":2,"score":0.774716854095459},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5757918357849121},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5555598139762878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5551314353942871},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5338960886001587},{"id":"https://openalex.org/C43044207","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Venous blood","level":2,"score":0.5033497214317322},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4735131561756134},{"id":"https://openalex.org/C2777796830","wikidata":"https://www.wikidata.org/wiki/Q1529519","display_name":"Glasgow Outcome Scale","level":3,"score":0.4715918302536011},{"id":"https://openalex.org/C2780347030","wikidata":"https://www.wikidata.org/wiki/Q344843","display_name":"APACHE II","level":3,"score":0.43860459327697754},{"id":"https://openalex.org/C2778446481","wikidata":"https://www.wikidata.org/wiki/Q190404","display_name":"Central venous catheter","level":3,"score":0.42991524934768677},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.42921626567840576},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37956950068473816},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3600538372993469},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2846773862838745},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2614297866821289},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.18072277307510376},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1620/tjem.211.387","doi":"https://doi.org/10.1620/tjem.211.387","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.211.387","pdf_url":"https://www.jstage.jst.go.jp/article/tjem/211/4/211_4_387/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:17409679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17409679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1620/tjem.211.387","doi":"https://doi.org/10.1620/tjem.211.387","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.211.387","pdf_url":"https://www.jstage.jst.go.jp/article/tjem/211/4/211_4_387/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8899999856948853,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982938288.pdf","grobid_xml":"https://content.openalex.org/works/W1982938288.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1968649148","https://openalex.org/W1970885006","https://openalex.org/W1982550537","https://openalex.org/W1988644394","https://openalex.org/W1989461358","https://openalex.org/W1991029837","https://openalex.org/W1992333318","https://openalex.org/W1995089583","https://openalex.org/W1997012788","https://openalex.org/W1997466305","https://openalex.org/W2012338377","https://openalex.org/W2015917405","https://openalex.org/W2021355535","https://openalex.org/W2022888171","https://openalex.org/W2030688762","https://openalex.org/W2034425798","https://openalex.org/W2035136014","https://openalex.org/W2039204603","https://openalex.org/W2041456603","https://openalex.org/W2055061246","https://openalex.org/W2060044641","https://openalex.org/W2067889266","https://openalex.org/W2073237925","https://openalex.org/W2081036098","https://openalex.org/W2097665403","https://openalex.org/W2117992648","https://openalex.org/W2122828189","https://openalex.org/W2122946630","https://openalex.org/W2135380777","https://openalex.org/W2138889905","https://openalex.org/W2142731321","https://openalex.org/W2160555624","https://openalex.org/W2191857417","https://openalex.org/W2311551614","https://openalex.org/W2318945846","https://openalex.org/W2340007070","https://openalex.org/W2438332021","https://openalex.org/W4232818222"],"related_works":["https://openalex.org/W2018467797","https://openalex.org/W1983474538","https://openalex.org/W2046951316","https://openalex.org/W2789857781","https://openalex.org/W2352009212","https://openalex.org/W2796054324","https://openalex.org/W2004035311","https://openalex.org/W2418849313","https://openalex.org/W2803136788","https://openalex.org/W193685198"],"abstract_inverted_index":{"Because":[0],"of":[1,17,35,40,70,83,88,120,134,172,196],"complex":[2],"pathophysiology":[3],"and":[4,21,62,66,128,178,181,221],"severe":[5,47,209],"consequences,":[6],"traumatic":[7,105],"brain":[8,106],"injuries":[9],"(TBI)":[10],"are":[11],"an":[12,202],"important":[13],"medical":[14],"problem.":[15],"Pathophysiology":[16],"TBI":[18,48,75],"includes":[19],"local":[20],"systemic":[22],"stress":[23],"response,":[24],"in":[25,43,56,67,123,139,146,163,206],"which":[26],"interleukin-8":[27],"(IL-8)":[28],"is":[29,49],"considered":[30],"as":[31,166,168,218],"a":[32],"key":[33],"mediator":[34],"neuroinflammation.":[36],"However,":[37],"prognostic":[38,159,215],"relevance":[39],"IL-8":[41,53,121,135,162,197],"measurement":[42],"adult":[44],"patients":[45,72,85,101,207],"with":[46,73,97,208],"not":[50],"certain.":[51],"Therefore,":[52],"was":[54,116,136],"determined":[55],"blood":[57,165],"samples":[58],"from":[59],"central":[60,130,192],"venous":[61,131,193],"jugular":[63],"bulb":[64],"catheter":[65],"cerebrospinal":[68,124],"fluid":[69,125],"twenty":[71],"isolated":[74],"at":[76,198],"admission":[77,199],"to":[78,104,212],"Intensive":[79],"Care":[80],"Unit.":[81],"None":[82],"the":[84,109,164,170,191],"had":[86],"history":[87],"stroke,":[89],"dementia,":[90],"autoimmune":[91],"diseases,":[92],"acute":[93],"infection":[94],"or":[95],"medication":[96],"anti-inflammatory":[98],"drugs.":[99],"Ten":[100],"died":[102],"due":[103],"injury,":[107],"while":[108],"other":[110],"ten":[111],"recovered":[112],"well.":[113],"While":[114],"there":[115],"no":[117],"significant":[118,158],"difference":[119],"levels":[122],"between":[126],"survivors":[127,140],"nonsurvivors,":[129],"plasma":[132,194],"level":[133],"significantly":[137],"lower":[138],"(71.00":[141],"+/-":[142,149],"14.17":[143],"pg/ml),":[144],"than":[145],"nonsurvivors":[147],"(111.26":[148],"16.9":[150],"pg/ml).":[151],"Receiver":[152],"Operating":[153],"Characteristic":[154],"(ROC)":[155],"analysis":[156],"revealed":[157],"value":[160],"for":[161,169],"well":[167],"age":[171],"patients,":[173],"Glasgow":[174],"Coma":[175],"Scale":[176],"(GCS)":[177],"Acute":[179],"Physiologic":[180],"Chronic":[182],"Health":[183],"Evaluation":[184],"(APACHE":[185],"II).":[186],"These":[187],"findings":[188],"suggest":[189],"that":[190],"values":[195],"might":[200],"be":[201],"early":[203],"predictive":[204],"marker":[205],"TBI,":[210],"comparative":[211],"standard":[213],"clinical":[214],"markers":[216],"such":[217],"APACHE":[219],"II":[220],"GCS.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}