{"id":"https://openalex.org/W1982929541","doi":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","title":"Early developmental expression pattern of retinoblastoma tumor suppressor mRNA indicates a role in the epithelial-to-mesenchyme transformation of endocardial cushion cells","display_name":"Early developmental expression pattern of retinoblastoma tumor suppressor mRNA indicates a role in the epithelial-to-mesenchyme transformation of endocardial cushion cells","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1982929541","doi":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","mag":"1982929541","pmid":"https://pubmed.ncbi.nlm.nih.gov/11241829"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","doi":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0177%2820010301%29220%3A3%3C198%3A%3AAID-DVDY1103%3E3.0.CO%3B2-T","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0177%2820010301%29220%3A3%3C198%3A%3AAID-DVDY1103%3E3.0.CO%3B2-T","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Wagner","raw_affiliation_strings":["Center for Cardiovascular and Muscle Research, Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA. mwagner@netmail.hscbklyn.edu","Center for Cardiovascular and Muscle Research Department of Anatomy and Cell Biology State University of New York Health Science Center at Brooklyn Brooklyn, New York 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular and Muscle Research, Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA. mwagner@netmail.hscbklyn.edu","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]},{"raw_affiliation_string":"Center for Cardiovascular and Muscle Research Department of Anatomy and Cell Biology State University of New York Health Science Center at Brooklyn Brooklyn, New York 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001248147","display_name":"Kathryn Miles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Miles","raw_affiliation_strings":["Center for Cardiovascular and Muscle Research, Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular and Muscle Research, Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061797233","display_name":"M.A.Q. Siddiqui","orcid":"https://orcid.org/0000-0002-7966-412X","observed_orcids":["https://orcid.org/0000-0002-7966-412X"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A.Q. Siddiqui","raw_affiliation_strings":["Center for Cardiovascular and Muscle Research, Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular and Muscle Research, Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.3262,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.51219316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"220","issue":"3","first_page":"198","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.06809999793767929,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/heart-tube","display_name":"heart tube","score":0.8159999847412109},{"id":"https://openalex.org/keywords/epicardium","display_name":"epicardium","score":0.7639999985694885},{"id":"https://openalex.org/keywords/heart-septation","display_name":"heart septation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.5239999890327454},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.8140000104904175},{"id":"https://openalex.org/keywords/rb-phosphorylation","display_name":"retinoblastoma protein phosphorylation","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8905642032623291},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5906726717948914},{"id":"https://openalex.org/C2775958995","wikidata":"https://www.wikidata.org/wiki/Q1933100","display_name":"Myotome","level":5,"score":0.5151944756507874},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.4894162714481354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4710756838321686},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.424976110458374},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.4179995656013489},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.41117367148399353},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.32678884267807007},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.32243573665618896},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.24941545724868774},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22032701969146729},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1995900273323059},{"id":"https://openalex.org/C2779018604","wikidata":"https://www.wikidata.org/wiki/Q1427600","display_name":"Somite","level":4,"score":0.1888751983642578}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004699","descriptor_name":"Endocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","doi":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0177%2820010301%29220%3A3%3C198%3A%3AAID-DVDY1103%3E3.0.CO%3B2-T","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:11241829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11241829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","doi":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0177(20010301)220:3<198::aid-dvdy1103>3.0.co;2-t","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0177%2820010301%29220%3A3%3C198%3A%3AAID-DVDY1103%3E3.0.CO%3B2-T","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3802053891","display_name":"CARDIAC PROGENITOR CELL DIFFERENTIATION","funder_award_id":"R01HL053573","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6916677619","display_name":null,"funder_award_id":"HL 53573","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309644","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08"},{"id":"https://openalex.org/F4320325355","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982929541.pdf","grobid_xml":"https://content.openalex.org/works/W1982929541.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W165064156","https://openalex.org/W197395184","https://openalex.org/W209865686","https://openalex.org/W1970424369","https://openalex.org/W1972607682","https://openalex.org/W1981778110","https://openalex.org/W1993492313","https://openalex.org/W1999330214","https://openalex.org/W2007061495","https://openalex.org/W2012469696","https://openalex.org/W2012792646","https://openalex.org/W2017878349","https://openalex.org/W2027080314","https://openalex.org/W2034440981","https://openalex.org/W2043179338","https://openalex.org/W2070437632","https://openalex.org/W2072964604","https://openalex.org/W2074198681","https://openalex.org/W2081557945","https://openalex.org/W2083000111","https://openalex.org/W2086651326","https://openalex.org/W2089011655","https://openalex.org/W2105214966","https://openalex.org/W2140034535","https://openalex.org/W2146000645","https://openalex.org/W2148454249","https://openalex.org/W2149263697","https://openalex.org/W2151868383","https://openalex.org/W2154384311","https://openalex.org/W2160182070","https://openalex.org/W2169927110","https://openalex.org/W2176077507","https://openalex.org/W2200223998","https://openalex.org/W2236036235","https://openalex.org/W2417039675","https://openalex.org/W2748693789","https://openalex.org/W3021597811","https://openalex.org/W4254469900"],"related_works":["https://openalex.org/W7099255588","https://openalex.org/W165064156","https://openalex.org/W2021295713","https://openalex.org/W2417531610","https://openalex.org/W2096748390","https://openalex.org/W2117201450","https://openalex.org/W1947079289","https://openalex.org/W2166388925","https://openalex.org/W73523141","https://openalex.org/W2228736764"],"abstract_inverted_index":{"The":[0],"earliest":[1],"stages":[2],"of":[3,11,28,44,53,87,124,142,155,166,176,195,224,235,239,245,251,257,272,283,289,297,306,314],"embryonic":[4,193],"development":[5,178],"are":[6],"characterized":[7],"by":[8,109,200,213],"the":[9,36,41,54,61,66,74,85,88,140,173,186,236,240,246,252,281,290,295,303,312],"generation":[10],"precursor":[12],"cell":[13,62,259],"populations":[14],"that":[15,59,105,113,135],"differentiate":[16],"and":[17,21,33,49,158,181,248],"coalesce":[18],"into":[19],"tissue":[20,32],"organ":[22,34],"primordia.":[23],"To":[24,70],"provide":[25],"sufficient":[26,209],"numbers":[27],"differentiated":[29],"cells":[30,45,234,244,250,288,299],"for":[31],"formation,":[35],"differentiative":[37],"as":[38,40,170,172,198],"well":[39],"proliferative":[42,55],"processes":[43],"must":[46],"be":[47,211,231],"controlled":[48],"coordinated.":[50],"Potential":[51],"regulators":[52],"process":[56,305],"include":[57],"molecules":[58,77],"control":[60,154],"cycle,":[63],"in":[64,80,94,100,214,286,311],"particular,":[65],"tumor":[67,90],"suppressor":[68,91],"proteins.":[69],"begin":[71],"to":[72,116,139,146,150,210,230,233,265,300],"understand":[73],"role":[75],"such":[76],"can":[78],"play":[79],"development,":[81],"we":[82],"have":[83,276],"studied":[84],"expression":[86,164,194,282],"retinoblastoma":[89],"(Rb)":[92],"gene":[93,112],"early":[95,101,171,192,241,291,309],"chicken":[96,102,177],"development.":[97,161,225],"Our":[98],"studies":[99,279],"embryos":[103],"show":[104],"Rb":[106,118,133,156,167,196,206,226,284],"is":[107],"encoded":[108],"a":[110,125,267],"single":[111],"gives":[114],"rise":[115],"several":[117],"mRNA":[119,129,168,197,207,227,285],"isoforms":[120,130],"through":[121,183],"alternative":[122],"splicing":[123],"primary":[126],"transcript.":[127],"These":[128],"potentially":[131],"encode":[132],"proteins":[134],"differ":[136],"with":[137],"respect":[138],"number":[141],"sequence":[143],"motifs":[144],"known":[145],"target":[147],"cyclin-dependent":[148],"kinases":[149],"Rb,":[151],"suggesting":[152],"dynamic":[153],"phosphorylation":[157],"function":[159],"during":[160],"This":[162],"complex":[163],"pattern":[165],"begins":[169],"blastoderm":[174],"stage":[175,184,188,222],"(stage":[179],"3)":[180],"continues":[182],"18,":[185],"latest":[187],"examined.":[189],"Despite":[190],"this":[191],"detected":[199,212],"reverse":[201],"transcription":[202],"polymerase":[203],"chain":[204],"reaction,":[205],"levels":[208],"situ":[215],"hybridization":[216],"were":[217],"not":[218],"expressed":[219],"until":[220],"after":[221],"14":[223],"was":[228],"found":[229],"localized":[232],"endocardial":[237,287],"cushions":[238],"heart":[242,292,315],"tube,":[243,293],"epicardium,":[247],"myogenic":[249],"somitic":[253],"myotome.":[254],"Interestingly,":[255],"each":[256],"these":[258,298],"types":[260],"undergoes":[261],"an":[262,308],"epithelial-to-mesenchyme":[263],"transformation":[264],"form":[266],"migratory":[268],"and/or":[269],"invasive":[270],"population":[271],"mesenchymal":[273],"cells.":[274],"We":[275],"focused":[277],"our":[278],"on":[280],"because":[294],"transition":[296],"mesenchyme":[301],"initiates":[302],"important":[304],"septation,":[307],"step":[310],"formation":[313],"valves.":[316]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}