{"id":"https://openalex.org/W1982926533","doi":"https://doi.org/10.1007/s007760050064","title":"Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation*","display_name":"Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation*","publication_year":1998,"publication_date":"1998-11-01","ids":{"openalex":"https://openalex.org/W1982926533","doi":"https://doi.org/10.1007/s007760050064","mag":"1982926533","pmid":"https://pubmed.ncbi.nlm.nih.gov/9811988"},"language":"en","primary_location":{"id":"doi:10.1007/s007760050064","doi":"https://doi.org/10.1007/s007760050064","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s007760050064","pdf_url":null,"source":{"id":"https://openalex.org/S170674194","display_name":"Journal of Orthopaedic Science","issn_l":"0949-2658","issn":["0949-2658","1436-2023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1982926533"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041978225","display_name":"Charles H. Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles H. Turner","raw_affiliation_strings":["Department of Orthopaedic Surgery, Biomechanics and Biomaterials Research Center and Indiana University School of Medicine, IUPUI, Indianapolis, IN 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Biomechanics and Biomaterials Research Center and Indiana University School of Medicine, IUPUI, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071094610","display_name":"Fredrick M. Pavalko","orcid":"https://orcid.org/0000-0001-6272-4512","observed_orcids":["https://orcid.org/0000-0001-6272-4512"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredrick M. Pavalko","raw_affiliation_strings":["Department of Physiology, Biomechanics and Biomaterials Research Center and Indiana University School of Medicine, IUPUI Indianapolis, IN 46202, USA","Department of Physiology, Biomechanics and Biomaterials Research Center and Indiana University School of Medicine, IUPUI, Indianapolis, IN 46202, USA, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biomechanics and Biomaterials Research Center and Indiana University School of Medicine, IUPUI Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Physiology, Biomechanics and Biomaterials Research Center and Indiana University School of Medicine, IUPUI, Indianapolis, IN 46202, USA, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.3337,"has_fulltext":false,"cited_by_count":401,"citation_normalized_percentile":{"value":0.38202247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"3","issue":"6","first_page":"346","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.34769999980926514,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-mechanotransduction","display_name":"bone mechanotransduction","score":0.875},{"id":"https://openalex.org/keywords/bone-adaptation","display_name":"bone adaptation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.5669999718666077},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.871999979019165},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8560000061988831},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":1.0},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.8679999709129333},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":1.0},{"id":"https://openalex.org/keywords/dynamic-loading","display_name":"dynamic loading","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bone-structure","display_name":"bone structure","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.9370177984237671},{"id":"https://openalex.org/C2778383842","wikidata":"https://www.wikidata.org/wiki/Q815284","display_name":"Mechanical load","level":2,"score":0.6234930753707886},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5774290561676025},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.5271776914596558},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.5250829458236694},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5141868591308594},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5043848752975464},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.48811206221580505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45874059200286865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45429033041000366},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4446210563182831},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3435535728931427},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3273230195045471},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30088478326797485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22311195731163025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08287429809570312},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08245405554771423},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08041492104530334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s007760050064","doi":"https://doi.org/10.1007/s007760050064","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s007760050064","pdf_url":null,"source":{"id":"https://openalex.org/S170674194","display_name":"Journal of Orthopaedic Science","issn_l":"0949-2658","issn":["0949-2658","1436-2023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Science","raw_type":"journal-article"},{"id":"pmid:9811988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9811988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1486376581","https://openalex.org/W1628998952","https://openalex.org/W1784155883","https://openalex.org/W1811174311","https://openalex.org/W1887623574","https://openalex.org/W1932241391","https://openalex.org/W1963928878","https://openalex.org/W1971095040","https://openalex.org/W1982563976","https://openalex.org/W1994596418","https://openalex.org/W1996847758","https://openalex.org/W1997812904","https://openalex.org/W1999235348","https://openalex.org/W2000520037","https://openalex.org/W2003355120","https://openalex.org/W2015820436","https://openalex.org/W2022926375","https://openalex.org/W2025046506","https://openalex.org/W2025753984","https://openalex.org/W2027914516","https://openalex.org/W2027946603","https://openalex.org/W2032031117","https://openalex.org/W2037650463","https://openalex.org/W2038450591","https://openalex.org/W2041428921","https://openalex.org/W2045964578","https://openalex.org/W2048492086","https://openalex.org/W2055407120","https://openalex.org/W2056104802","https://openalex.org/W2067083395","https://openalex.org/W2067986741","https://openalex.org/W2072424207","https://openalex.org/W2075027785","https://openalex.org/W2077540123","https://openalex.org/W2079144140","https://openalex.org/W2084087342","https://openalex.org/W2087733742","https://openalex.org/W2096925272","https://openalex.org/W2100983000","https://openalex.org/W2114495080","https://openalex.org/W2130934825","https://openalex.org/W2131407581","https://openalex.org/W2135872262","https://openalex.org/W2139683407","https://openalex.org/W2147866453","https://openalex.org/W2149759922","https://openalex.org/W2163414758","https://openalex.org/W2164763877","https://openalex.org/W2169051713","https://openalex.org/W2253282519","https://openalex.org/W2254591137","https://openalex.org/W2322108297","https://openalex.org/W2409270725","https://openalex.org/W2473404851","https://openalex.org/W2473772575","https://openalex.org/W2503369221","https://openalex.org/W4246536439","https://openalex.org/W4255217118"],"related_works":["https://openalex.org/W2012388796","https://openalex.org/W2114327568","https://openalex.org/W2035671623","https://openalex.org/W2890145903","https://openalex.org/W1584039574","https://openalex.org/W2063607339","https://openalex.org/W1602781213","https://openalex.org/W4211026209","https://openalex.org/W202166469","https://openalex.org/W3012505820"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
