{"id":"https://openalex.org/W1982923975","doi":"https://doi.org/10.1097/00000658-198511000-00016","title":"Oxygen Free Radical Induced Damage in Kidneys Subjected to Warm Ischemia and Reperfusion","display_name":"Oxygen Free Radical Induced Damage in Kidneys Subjected to Warm Ischemia and Reperfusion","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W1982923975","doi":"https://doi.org/10.1097/00000658-198511000-00016","mag":"1982923975","pmid":"https://pubmed.ncbi.nlm.nih.gov/3840348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1250979"},"language":"en","primary_location":{"id":"doi:10.1097/00000658-198511000-00016","doi":"https://doi.org/10.1097/00000658-198511000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000658-198511000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S157664895","display_name":"Annals of Surgery","issn_l":"0003-4932","issn":["0003-4932","1528-1140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1250979","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070137768","display_name":"Gary L. Baker","orcid":"https://orcid.org/0000-0002-4658-2988","observed_orcids":["https://orcid.org/0000-0002-4658-2988"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GARY L. BAKER","raw_affiliation_strings":["Departments of Surgery and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110120006","display_name":"Robert J. Corry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT J. CORRY","raw_affiliation_strings":["Departments of Surgery and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041617285","display_name":"Anne P. Autor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANNE P. AUTOR","raw_affiliation_strings":["Departments of Surgery and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery and Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":11.5928,"has_fulltext":false,"cited_by_count":226,"citation_normalized_percentile":{"value":0.99058045,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"202","issue":"5","first_page":"628","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.6840000152587891},{"id":"https://openalex.org/keywords/warm-ischemia","display_name":"warm ischemia","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9259999990463257},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9430000185966492},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.996999979019165},{"id":"https://openalex.org/keywords/renal-artery-occlusion","display_name":"renal artery occlusion","score":0.7210000157356262},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8270000219345093},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4259999990463257},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.699999988079071},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.4300000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8507282733917236},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7883942127227783},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.7561991214752197},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6747036576271057},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.663571834564209},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6172271966934204},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.555852472782135},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.4703562259674072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4655369818210602},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4202041029930115},{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.4173605442047119},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.41101253032684326},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.37248626351356506},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34678471088409424},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3212534785270691},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.24658048152923584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1329134702682495},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1291121542453766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06895723938941956}],"mesh":[{"descriptor_ui":"D000493","descriptor_name":"Allopurinol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000658-198511000-00016","doi":"https://doi.org/10.1097/00000658-198511000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000658-198511000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S157664895","display_name":"Annals of Surgery","issn_l":"0003-4932","issn":["0003-4932","1528-1140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1250979","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1250979","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Surg","raw_type":"Text"},{"id":"pmid:3840348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3840348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1250979","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1250979","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Surg","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W71643527","https://openalex.org/W153758560","https://openalex.org/W195217094","https://openalex.org/W1506333726","https://openalex.org/W1522676079","https://openalex.org/W1680799029","https://openalex.org/W1940436875","https://openalex.org/W1996723509","https://openalex.org/W2004099545","https://openalex.org/W2013813451","https://openalex.org/W2019859059","https://openalex.org/W2037269016","https://openalex.org/W2043008718","https://openalex.org/W2048041047","https://openalex.org/W2050590496","https://openalex.org/W2055785937","https://openalex.org/W2056168344","https://openalex.org/W2060364171","https://openalex.org/W2064795472","https://openalex.org/W2065842089","https://openalex.org/W2068313599","https://openalex.org/W2069809261","https://openalex.org/W2078683430","https://openalex.org/W2092426540","https://openalex.org/W2094314124","https://openalex.org/W2097744068","https://openalex.org/W2119968334","https://openalex.org/W2139723538","https://openalex.org/W2146800979","https://openalex.org/W2151473160","https://openalex.org/W2158513847","https://openalex.org/W2288541035","https://openalex.org/W2396070378","https://openalex.org/W2396425273","https://openalex.org/W2404677189","https://openalex.org/W2410702203","https://openalex.org/W2417913690","https://openalex.org/W2418927595"],"related_works":["https://openalex.org/W2028990654","https://openalex.org/W2016684811","https://openalex.org/W2412203475","https://openalex.org/W2074513152","https://openalex.org/W2139723538","https://openalex.org/W2734159548","https://openalex.org/W2181717946","https://openalex.org/W2084798879","https://openalex.org/W2443880269","https://openalex.org/W2125533916"],"abstract_inverted_index":{"Superoxide":[0,25],"anion":[1],"free":[2,30],"radical":[3,31],"(O2-.)":[4],"has":[5,36,53],"been":[6,37,54],"implicated":[7],"in":[8,17,63,121,146,189,281,285,303,389],"the":[9,57,78,113,122,151,163,190,238,249,263,276,286,304,313,320,336,356],"pathogenesis":[10],"of":[11,49,60,70,80,99,112,124,162,234,248,262,315,335,358,371],"tissue":[12,65,373],"injury":[13],"consequent":[14],"to":[15,40,76,82,158,179,198,205,227,243,294,319,353],"ischemia/reperfusion":[16],"several":[18],"different":[19],"organs,":[20],"including":[21],"heart":[22],"and":[23,110,136,202,231,360],"bowel.":[24],"dismutase":[26],"(SOD),":[27],"an":[28,67],"enzyme":[29],"scavenger":[32],"specific":[33],"for":[34,117],"O2-.,":[35],"used":[38],"successfully":[39],"protect":[41,83],"these":[42,159],"organs":[43],"from":[44,88,375,391],"structural":[45],"damage":[46,86,322],"during":[47,72,275],"reoxygenation":[48],"ischemic":[50,125,228,288,327],"tissue.":[51],"It":[52],"suggested":[55],"that":[56],"catalytic":[58],"action":[59,314],"xanthine":[61,316],"oxidase":[62,317],"injured":[64],"is":[66],"important":[68],"source":[69],"O2-.":[71],"reoxygenation.":[73],"In":[74,155],"order":[75],"evaluate":[77],"potential":[79],"SOD":[81,167,191,211,216,367],"against":[84],"kidney":[85,321,372],"resulting":[87],"transient":[89],"ischemia":[90,102,218,239,359,378],"followed":[91],"by":[92],"reperfusion":[93,169,361],"with":[94,166,209,308,332,339],"oxygenated":[95],"blood,":[96],"a":[97],"model":[98],"warm":[100],"renal":[101,115,382],"was":[103,131,139,194,241,272,386],"studied.":[104],"LBNF1":[105],"rats":[106,127,147,183,193,284,306],"underwent":[107],"right":[108],"nephrectomy":[109],"occlusion":[111],"left":[114],"artery":[116],"45":[118,325],"minutes.":[119],"Survival":[120],"group":[123],"untreated":[126,229,250,287],"(N":[128,170,184,212,219,252,267,341],"=":[129,171,185,213,220,253,268,342],"30)":[130],"56%":[132],"at":[133,256,346],"7":[134,176,257,347],"days":[135,177,258,302],"serum":[137,235,291],"creatinine":[138,188,271,292,350],"greatly":[140,273],"elevated":[141,196,274],"(p":[142,296],"less":[143,297],"than":[144,298,365],"0.01)":[145],"remaining":[148],"alive":[149,174,345],"over":[150],"full":[152,277],"7-day":[153,278],"period.":[154],"strong":[156],"contrast":[157],"results,":[160],"all":[161,282],"animals":[164,230,251,265,337,376],"treated":[165,192,208,307,331,338],"before":[168,217],"18)":[172],"were":[173,330,344],"after":[175,300,323,355,366,377],"similar":[178],"sham":[180],"operated":[181],"control":[182],"8).":[186],"Serum":[187,270,349],"significantly":[195],"only":[197,246],"postoperative":[199],"day":[200],"3":[201],"thereafter":[203],"returned":[204,293,352],"normal.":[206],"Rats":[207],"inactive":[210],"4)":[214,221],"or":[215],"had":[222],"decreased":[223],"survival":[224],"rates":[225],"compared":[226],"prolonged":[232],"elevation":[233],"creatinine.":[236],"When":[237],"time":[240],"extended":[242],"60":[244],"minutes,":[245],"19%":[247],"16)":[254],"survived":[255,266],"whereas":[259,290],"nearly":[260],"60%":[261],"SOD-treated":[264,392],"19).":[269],"observation":[279],"period":[280],"surviving":[283,305],"group,":[289],"normal":[295,354],"0.05)":[299],"4":[301],"SOD.":[309],"To":[310],"test":[311],"whether":[312],"contributed":[318],"reoxygenation,":[324],"min.":[326],"rat":[328],"kidneys":[329,390],"allopurinol.":[333],"All":[334],"allopurinol":[340],"12)":[343],"days.":[348],"values":[351],"episode":[357],"but":[362],"more":[363],"slowly":[364],"treatment.":[368],"Histologic":[369],"evaluation":[370],"taken":[374],"alone":[379],"showed":[380],"extensive":[381],"tubular":[383],"damage,":[384],"which":[385],"essentially":[387],"absent":[388],"animals.(ABSTRACT":[393],"TRUNCATED":[394],"AT":[395],"400":[396],"WORDS)":[397]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}