{"id":"https://openalex.org/W1982923906","doi":"https://doi.org/10.1158/1538-7445.am2011-2983","title":"Abstract 2983: Sgo1 haploinsufficiency contributes to enhanced colon carcinogenesis in mice and yet associated with high colonic epithelial apoptosis","display_name":"Abstract 2983: Sgo1 haploinsufficiency contributes to enhanced colon carcinogenesis in mice and yet associated with high colonic epithelial apoptosis","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1982923906","doi":"https://doi.org/10.1158/1538-7445.am2011-2983","mag":"1982923906"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-2983","doi":"https://doi.org/10.1158/1538-7445.am2011-2983","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2983","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043457676","display_name":"Hiroshi Y. Yamada","orcid":"https://orcid.org/0000-0002-0536-5581","observed_orcids":["https://orcid.org/0000-0002-0536-5581"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Y. Yamada","raw_affiliation_strings":["1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451828","display_name":"Yuting Zhang","orcid":"https://orcid.org/0000-0002-2547-8831","observed_orcids":["https://orcid.org/0000-0002-2547-8831"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuting Zhang","raw_affiliation_strings":["1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048237280","display_name":"Wei Hao Dai","orcid":"https://orcid.org/0000-0003-0169-8327","observed_orcids":["https://orcid.org/0000-0003-0169-8327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Dai","raw_affiliation_strings":["2New York Medical University, Tuxedo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2New York Medical University, Tuxedo, NY","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101461393","display_name":"Chinthalapally V. Rao","orcid":"https://orcid.org/0000-0002-5715-7979","observed_orcids":["https://orcid.org/0000-0002-5715-7979"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinthalapally V. Rao","raw_affiliation_strings":["1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Oklahoma Health Sciences Ctr., Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"2983","last_page":"2983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.26420000195503235,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/chromosome-cohesion","display_name":"chromosome cohesion","score":0.7459999918937683},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.8389999866485596},{"id":"https://openalex.org/keywords/aberrant-crypt-foci","display_name":"aberrant crypt foci","score":0.968999981880188},{"id":"https://openalex.org/keywords/azoxymethane","display_name":"azoxymethane","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6520000100135803},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pituitary-microadenoma","display_name":"pituitary microadenoma","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.3479999899864197},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4959999918937683},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.839066207408905},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6787976622581482},{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.6721013784408569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5538507699966431},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47039517760276794},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.4520249366760254},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.27983349561691284},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21735131740570068},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20313191413879395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16041728854179382},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15745779871940613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-2983","doi":"https://doi.org/10.1158/1538-7445.am2011-2983","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2983","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311074412","https://openalex.org/W1510243827","https://openalex.org/W2801848122","https://openalex.org/W992053411","https://openalex.org/W2050832735","https://openalex.org/W2053672068","https://openalex.org/W4389508150","https://openalex.org/W2171571276","https://openalex.org/W1981363723","https://openalex.org/W2072594716"],"abstract_inverted_index":{"Abstract":[0],"Inactivation":[1],"of":[2,8,15,61,75,107,167,182,197,283,287,309,314],"Shugoshin-1":[3],"(Sgo1)":[4],"function":[5],"or":[6],"depletion":[7,60],"Sgo1":[9,17,38,62,76,90,284],"in":[10,22,30,43,50,69,77,97,203,218,240,253,268,285],"mammalian":[11],"cells":[12,267],"causes":[13],"missegregation":[14],"chromosome.":[16],"plays":[18],"an":[19,254],"obligate":[20],"role":[21,49,74],"chromosome":[23,32],"cohesion":[24],"and":[25,111,138,143,180,226,247,290,299],"its":[26],"defect":[27,239],"is":[28],"implicated":[29],"high":[31],"instability.":[33],"Recent":[34],"studies":[35],"indicate":[36],"that":[37,59,238],"levels":[39],"were":[40,113,200],"significantly":[41],"decreased":[42],"human":[44],"colonic":[45,101,134,141,198,216,294],"tumors,":[46],"suggesting":[47],"a":[48],"colon":[51,95],"carcinogenesis.":[52],"Here,":[53],"we":[54,80,131],"report":[55],"for":[56,124,133,276,318],"first":[57,278],"time":[58,279],"lead":[63],"to":[64,100,293],"the":[65,73,94,159,163,165,236,277,310,315],"enhanced":[66],"colorectal":[67,78],"carcinogenesis":[68,96,263],"mice.":[70],"To":[71],"understand":[72],"cancer,":[79],"have":[81],"established":[82],"haploinsufficient":[83,204],"Sgo1+/-":[84,112,174,188,210],"mouse":[85],"model.":[86],"We":[87],"tested":[88],"whether":[89],"deficiency":[91],"would":[92],"enhance":[93,248],"animal":[98],"exposed":[99],"specific":[102],"carcinogen.":[103],"At":[104],"eight":[105],"weeks":[106],"age":[108],"mice":[109,147,156,205,221,258],"Sgo1+/+":[110,155,231],"treated":[114],"with":[115,129,230,271],"azoxymethane":[116],"(AOM),":[117],"s.c.,":[118],"4":[119],"mg/kg":[120],"BW,":[121],"twice":[122],"weekly":[123],"four":[125],"weeks.":[126],"Upon":[127],"treatment":[128],"AOM,":[130],"analyzed":[132],"crypt":[135,169],"cell-cycle":[136],"modifications":[137],"later":[139],"stage":[140],"ACF":[142],"tumor":[144],"formation.":[145],"Sgo1-/+":[146,220,257],"showed":[148],"higher":[149,202,223,269],"acute":[150],"cell":[151,249,272],"death":[152,250],"rate":[153,270],"than":[154],"soon":[157],"after":[158],"AOM-treatment.":[160],"However,":[161],"at":[162],"endpoint,":[164],"number":[166,196],"aberrant":[168,183],"foci":[170],"[Sgo1+/+,":[171,206],"4\u00b11.41":[172],"vs":[173,187,209],"12.2":[175],"\u00b11.5,":[176],"mean":[177,191,195],"\u00b1SD,":[178,192],"p<0.0002]":[179],"multiplicity":[181],"crypts/foci":[184],"[Sgo1+/+":[185],"0.4\u00b10.32":[186],"3.8":[189],"\u00b10.57,":[190],"p<0.0001].":[193],"Importantly,":[194],"microadenoma":[199],"5-fold":[201],"0.8":[207],"\u00b10.45":[208],"5.0":[211],"\u00b1":[212],"1.2,":[213],"p<0001].":[214],"Normal-looking":[215],"mucosa":[217],"AOM-treated":[219],"expressed":[222],"Bcl2,":[224],"p53":[225],"COX-2":[227],"proteins":[228],"compared":[229],"type.":[232],"These":[233],"results":[234,275],"suggest":[235],"notion":[237],"mitotic":[241],"machinery":[242],"can":[243],"serve":[244],"both":[245],"oncogenic":[246],"by":[251,264,297],"apoptosis":[252],"environment-dependent":[255],"manner;":[256],"may":[259],"be":[260],"latently":[261],"antagonizing":[262],"removing":[265],"damaged":[266],"death.":[273],"Our":[274],"provide":[280],"functional":[281],"evidence":[282],"enhancement":[286],"precancerous":[288],"lesions,":[289],"their":[291],"progression":[292],"tumors.":[295],"(Supported":[296],"R01-CA-113349":[298],"R01-CA-102942)":[300],"Citation":[301],"Format:":[302],"{Authors}.":[303],"{Abstract":[304],"title}":[305],"[abstract].":[306],"In:":[307],"Proceedings":[308],"102nd":[311],"Annual":[312],"Meeting":[313],"American":[316],"Association":[317],"Cancer":[319,329],"Research;":[320],"2011":[321],"Apr":[322],"2-6;":[323],"Orlando,":[324],"FL.":[325],"Philadelphia":[326],"(PA):":[327],"AACR;":[328],"Res":[330],"2011;71(8":[331],"Suppl):Abstract":[332],"nr":[333],"2983.":[334],"doi:10.1158/1538-7445.AM2011-2983":[335]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}