{"id":"https://openalex.org/W1982922358","doi":"https://doi.org/10.1172/jci14255","title":"Mapping myasthenia gravis\u2013associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice","display_name":"Mapping myasthenia gravis\u2013associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice","publication_year":2002,"publication_date":"2002-04-15","ids":{"openalex":"https://openalex.org/W1982922358","doi":"https://doi.org/10.1172/jci14255","mag":"1982922358","pmid":"https://pubmed.ncbi.nlm.nih.gov/11956249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/150946"},"language":"en","primary_location":{"id":"doi:10.1172/jci14255","doi":"https://doi.org/10.1172/jci14255","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci14255","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/14255/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073765005","display_name":"Huan Yang","orcid":"https://orcid.org/0000-0003-1523-0338","observed_orcids":["https://orcid.org/0000-0003-1523-0338"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan Yang","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA","Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston TX 77555-1070, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston TX 77555-1070, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113554057","display_name":"Elzbieta Goluszko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elzbieta Goluszko","raw_affiliation_strings":["University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109087051","display_name":"Chella S. David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chella David","raw_affiliation_strings":["Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080114064","display_name":"David K. Okita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K. Okita","raw_affiliation_strings":["University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073547682","display_name":"Bianca M. Conti\u2010Fine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bianca Conti-Fine","raw_affiliation_strings":["University of\u00a0Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of\u00a0Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111568770","display_name":"Teh\u2010Sheng Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teh-sheng Chan","raw_affiliation_strings":["Microbiology And Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology And Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027111762","display_name":"Mathilde Poussin","orcid":"https://orcid.org/0000-0002-4603-3508","observed_orcids":["https://orcid.org/0000-0002-4603-3508"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathilde A. Poussin","raw_affiliation_strings":["University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074297051","display_name":"Premkumar Christadoss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Premkumar Christadoss","raw_affiliation_strings":["Microbiology And Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology And Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074297051"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.1008,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.90544436,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"109","issue":"8","first_page":"1111","last_page":"1120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myasthenia-gravis","display_name":"myasthenia gravis","score":1.0},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"acetylcholine receptor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hla-dq8","display_name":"HLA-DQ8","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hla-dr3","display_name":"HLA-DR3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hla-dq6","display_name":"HLA-DQ6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-class-ii-restriction","display_name":"HLA class II restriction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/experimental-autoimmune-myasthenia-gravis","display_name":"experimental autoimmune myasthenia gravis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hla-transgenic-mice","display_name":"HLA transgenic mice","score":0.8059999942779541},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.6700000166893005},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/acetylcholine-receptor-antibodies","display_name":"acetylcholine receptor antibodies","score":0.6880000233650208},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8299999833106995},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7960000038146973},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.795647382736206},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.739115834236145},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6531113386154175},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5948709845542908},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5927446484565735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.577346920967102},{"id":"https://openalex.org/C2779910283","wikidata":"https://www.wikidata.org/wiki/Q5630144","display_name":"HLA-DQ","level":5,"score":0.5139846205711365},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5117823481559753},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4939337372779846},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44197264313697815},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2877691984176636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1157563328742981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10006684064865112},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.05316281318664551},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009157","descriptor_name":"Myasthenia Gravis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015803","descriptor_name":"HLA-DR3 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015803","descriptor_name":"HLA-DR3 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015803","descriptor_name":"HLA-DR3 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci14255","doi":"https://doi.org/10.1172/jci14255","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci14255","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"doi:10.1172/jci200214255","doi":"https://doi.org/10.1172/jci200214255","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci200214255","pdf_url":"http://www.jci.org/articles/view/14255/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:150946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/150946","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:11956249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11956249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci200214255","doi":"https://doi.org/10.1172/jci200214255","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci200214255","pdf_url":"http://www.jci.org/articles/view/14255/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2826305733","display_name":null,"funder_award_id":"NS23919","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4550580776","display_name":"Regulatory CD4+ Tr cells in mouse EMG","funder_award_id":"R01NS023919","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982922358.pdf","grobid_xml":"https://content.openalex.org/works/W1982922358.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W117736859","https://openalex.org/W1496559392","https://openalex.org/W1507544251","https://openalex.org/W1535090095","https://openalex.org/W1547143247","https://openalex.org/W1561559732","https://openalex.org/W1564057145","https://openalex.org/W1567863626","https://openalex.org/W1572435187","https://openalex.org/W1580591368","https://openalex.org/W1648324978","https://openalex.org/W1652840914","https://openalex.org/W1739302847","https://openalex.org/W1797420984","https://openalex.org/W1909598959","https://openalex.org/W1947288464","https://openalex.org/W1953864717","https://openalex.org/W1967925048","https://openalex.org/W1993585245","https://openalex.org/W1996433151","https://openalex.org/W2001196959","https://openalex.org/W2014638786","https://openalex.org/W2014782935","https://openalex.org/W2019737604","https://openalex.org/W2020509196","https://openalex.org/W2024097681","https://openalex.org/W2032006313","https://openalex.org/W2043151956","https://openalex.org/W2044083482","https://openalex.org/W2046231107","https://openalex.org/W2058347590","https://openalex.org/W2060932594","https://openalex.org/W2063007878","https://openalex.org/W2070691098","https://openalex.org/W2083843104","https://openalex.org/W2090483910","https://openalex.org/W2094954825","https://openalex.org/W2098659453","https://openalex.org/W2107805551","https://openalex.org/W2118871422","https://openalex.org/W2126504125","https://openalex.org/W2126602046","https://openalex.org/W2139577993","https://openalex.org/W2148079333","https://openalex.org/W2161958048","https://openalex.org/W2430196448","https://openalex.org/W2889946516","https://openalex.org/W3135645624","https://openalex.org/W4248406156"],"related_works":["https://openalex.org/W2002197374","https://openalex.org/W2028110599","https://openalex.org/W2014782935","https://openalex.org/W1547143247","https://openalex.org/W2107805551","https://openalex.org/W1652840914","https://openalex.org/W2469304175","https://openalex.org/W189287581","https://openalex.org/W201744056","https://openalex.org/W1490998575"],"abstract_inverted_index":{"Susceptibility":[0],"to":[1,8,18,94,109,120,175,179],"myasthenia":[2],"gravis":[3],"(MG)":[4],"is":[5],"positively":[6,77],"linked":[7,17],"expression":[9,19],"of":[10,20,29,71,99,105,149],"HLA-DQ8":[11],"and":[12,15,45,47,50,82,103,126,153,156,159,164,177],"DR3":[13,115],"molecules":[14,76],"negatively":[16],"the":[21,26,72,107,112,183],"DQ6":[22,141],"molecule.":[23],"To":[24],"elucidate":[25],"molecular":[27],"basis":[28],"this":[30,121],"association,":[31],"we":[32,169],"have":[33],"induced":[34],"experimental":[35],"autoimmune":[36],"MG":[37,80],"(EAMG)":[38],"in":[39,48,62,140],"mice":[40,91,117,143],"transgenic":[41,53,90,116,142],"for":[42,67],"HLA-DQ8,":[43],"DQ6,":[44],"DR3,":[46],"DQ8xDQ6":[49],"DQ8xDR3":[51],"F(1)":[52],"mice,":[54],"by":[55,133,162],"immunization":[56],"with":[57,79,146],"human":[58],"acetylcholine":[59],"receptor":[60],"(H-AChR)":[61],"CFA.":[63],"Mice":[64],"expressing":[65],"transgenes":[66],"one":[68],"or":[69],"both":[70],"HLA":[73,134],"class":[74,135],"II":[75,136],"associated":[78,145],"(DQ8":[81],"DR3)":[83],"developed":[84],"EAMG.":[85],"T":[86],"cells":[87],"from":[88],"DQ8":[89,172],"responded":[92,119],"well":[93],"three":[95],"cytoplasmic":[96],"peptide":[97,165],"sequences":[98],"H-AChR":[100],"(alpha320-337,":[101],"alpha304-322,":[102],"alpha419-437),":[104],"which":[106],"response":[108],"alpha320-337":[110,127,185],"was":[111,144],"most":[113],"intense.":[114],"also":[118],"sequence":[122,184],"very":[123],"strongly.":[124],"H-AChR-":[125,163],"peptide-specific":[128],"lymphocyte":[129],"responses":[130],"were":[131],"restricted":[132],"molecules.":[137],"Disease":[138],"resistance":[139],"reduced":[147,157],"synthesis":[148],"anti-AChR":[150],"IgG,":[151],"IgG(2b),":[152],"IgG(2c)":[154],"Ab's":[155],"IL-2":[158],"IFN-gamma":[160],"secretion":[161],"alpha320-337-specific":[166],"lymphocytes.":[167],"Finally,":[168],"show":[170],"that":[171],"imparts":[173],"susceptibility":[174],"EAMG":[176],"responsiveness":[178],"an":[180],"epitope":[181],"within":[182],"as":[186],"a":[187],"dominant":[188],"trait.":[189]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}