{"id":"https://openalex.org/W1982916719","doi":"https://doi.org/10.1083/jcb.200703202","title":"Cyclin E overexpression impairs progression through mitosis by inhibiting APCCdh1","display_name":"Cyclin E overexpression impairs progression through mitosis by inhibiting APCCdh1","publication_year":2007,"publication_date":"2007-07-30","ids":{"openalex":"https://openalex.org/W1982916719","doi":"https://doi.org/10.1083/jcb.200703202","mag":"1982916719","pmid":"https://pubmed.ncbi.nlm.nih.gov/17664332"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200703202","doi":"https://doi.org/10.1083/jcb.200703202","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200703202","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2064850","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103460041","display_name":"Jamie M. Keck","orcid":"https://orcid.org/0009-0001-0436-7112","observed_orcids":["https://orcid.org/0009-0001-0436-7112"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie M. Keck","raw_affiliation_strings":["1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","*Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"*Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053038262","display_name":"Matthew K. Summers","orcid":"https://orcid.org/0000-0002-2482-0332","observed_orcids":["https://orcid.org/0000-0002-2482-0332"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Summers","raw_affiliation_strings":["2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305","Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014400550","display_name":"Donato Tedesco","orcid":"https://orcid.org/0000-0001-8525-0997","observed_orcids":["https://orcid.org/0000-0001-8525-0997"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donato Tedesco","raw_affiliation_strings":["1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","*Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"*Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081010389","display_name":"Susanna Ekholm\u2010Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna Ekholm-Reed","raw_affiliation_strings":["1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041907112","display_name":"Li-Chiou Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-Chiou Chuang","raw_affiliation_strings":["1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008558253","display_name":"Peter K. Jackson","orcid":"https://orcid.org/0000-0002-1742-2539","observed_orcids":["https://orcid.org/0000-0002-1742-2539"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter K. Jackson","raw_affiliation_strings":["2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305","Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110230366","display_name":"Steven I. Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven I. Reed","raw_affiliation_strings":["1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9746,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.89970909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"178","issue":"3","first_page":"371","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anaphase-promoting-complex","display_name":"anaphase-promoting complex","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cdh1","display_name":"CDH1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/prometaphase","display_name":"prometaphase","score":0.8259999752044678},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/securin","display_name":"securin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":1.0},{"id":"https://openalex.org/keywords/mitotic-progression","display_name":"mitotic progression","score":0.5289999842643738},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8192653656005859},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.7154843807220459},{"id":"https://openalex.org/C107888121","wikidata":"https://www.wikidata.org/wiki/Q418432","display_name":"Anaphase-promoting complex","level":5,"score":0.6728915572166443},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.6417655944824219},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6279336214065552},{"id":"https://openalex.org/C28179978","wikidata":"https://www.wikidata.org/wiki/Q5198263","display_name":"Cyclin A2","level":5,"score":0.6210806965827942},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6186591386795044},{"id":"https://openalex.org/C154202817","wikidata":"https://www.wikidata.org/wiki/Q14763006","display_name":"Prometaphase","level":5,"score":0.5980971455574036},{"id":"https://openalex.org/C53420372","wikidata":"https://www.wikidata.org/wiki/Q22299157","display_name":"Anaphase","level":4,"score":0.5942776799201965},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.5541062355041504},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.5112042427062988},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.4786280691623688},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.4487355351448059},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.40214353799819946},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.3940725326538086},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3889475464820862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2318052351474762},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.1892688274383545},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1472545564174652},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.10932815074920654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064173","descriptor_name":"Anaphase-Promoting Complex-Cyclosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064249","descriptor_name":"Securin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064249","descriptor_name":"Securin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064249","descriptor_name":"Securin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.200703202","doi":"https://doi.org/10.1083/jcb.200703202","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200703202","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmid:17664332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17664332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2064850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2064850","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2064850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2064850","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1022113250","display_name":null,"funder_award_id":"R01 CA078343","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1144447943","display_name":null,"funder_award_id":"CA 78343","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1312563061","display_name":"Cyclin Control DNA Replication and Mitosis","funder_award_id":"R01GM054811","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1690517240","display_name":"Postdoctoral Training in Tumor Biology","funder_award_id":"T32CA009151","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G278583102","display_name":null,"funder_award_id":"CA09151","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G296331722","display_name":null,"funder_award_id":"R56 CA078343","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G329676534","display_name":null,"funder_award_id":"GM-54811","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5249061671","display_name":null,"funder_award_id":"GM60439","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8286170774","display_name":null,"funder_award_id":"R01 GM060439","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W30931427","https://openalex.org/W177595770","https://openalex.org/W243911327","https://openalex.org/W1457122365","https://openalex.org/W1552046925","https://openalex.org/W1568139490","https://openalex.org/W1569755992","https://openalex.org/W1638194466","https://openalex.org/W1910656974","https://openalex.org/W1966383348","https://openalex.org/W1966797025","https://openalex.org/W1967853904","https://openalex.org/W1971079672","https://openalex.org/W1971254046","https://openalex.org/W1979669293","https://openalex.org/W1993507282","https://openalex.org/W1995788690","https://openalex.org/W1997643531","https://openalex.org/W1999491381","https://openalex.org/W2006659499","https://openalex.org/W2007229161","https://openalex.org/W2007853809","https://openalex.org/W2013680732","https://openalex.org/W2014012985","https://openalex.org/W2014089858","https://openalex.org/W2014682544","https://openalex.org/W2015141765","https://openalex.org/W2015851881","https://openalex.org/W2027789758","https://openalex.org/W2029620430","https://openalex.org/W2034898793","https://openalex.org/W2037209658","https://openalex.org/W2038197766","https://openalex.org/W2043957435","https://openalex.org/W2044016151","https://openalex.org/W2045463072","https://openalex.org/W2045589197","https://openalex.org/W2048109276","https://openalex.org/W2051960144","https://openalex.org/W2053855572","https://openalex.org/W2059492365","https://openalex.org/W2061064014","https://openalex.org/W2068494600","https://openalex.org/W2070026305","https://openalex.org/W2071152209","https://openalex.org/W2072659475","https://openalex.org/W2080252696","https://openalex.org/W2084796662","https://openalex.org/W2104906890","https://openalex.org/W2112854488","https://openalex.org/W2116045064","https://openalex.org/W2118668591","https://openalex.org/W2136644864","https://openalex.org/W2144942522","https://openalex.org/W2146084258","https://openalex.org/W2150922649","https://openalex.org/W2152028923","https://openalex.org/W2155881657","https://openalex.org/W2158679973","https://openalex.org/W2163122428","https://openalex.org/W2171852242","https://openalex.org/W2414175864"],"related_works":["https://openalex.org/W2034418667","https://openalex.org/W2026806619","https://openalex.org/W2062464324","https://openalex.org/W1979404830","https://openalex.org/W2045612398","https://openalex.org/W2009157674","https://openalex.org/W2076933905","https://openalex.org/W2989950645","https://openalex.org/W2051907463","https://openalex.org/W2109907800"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,6,23,38,52,65,72,100,110,133,140,153],"cyclin":[2,24,39,53,112,156,162],"E,":[3],"an":[4,108],"activator":[5],"cyclin-dependent":[7],"kinase":[8],"2,":[9],"has":[10,55],"been":[11],"linked":[12],"to":[13,27,84,94,114,127],"human":[14],"cancer.":[15],"In":[16,44,78,90],"cell":[17],"culture":[18],"models,":[19],"the":[20,50,62,69,75,97,130,137,151,161],"forced":[21],"expression":[22],"E":[25,40,54,113],"leads":[26],"aneuploidy":[28],"and":[29,128,155],"polyploidy,":[30],"which":[31],"is":[32],"consistent":[33],"with":[34],"a":[35,56],"direct":[36,57],"role":[37],"overexpression":[41,51],"in":[42,88,136],"tumorigenesis.":[43],"this":[45],"study,":[46],"we":[47],"show":[48,149],"that":[49,121,150],"effect":[58],"on":[59],"progression":[60],"through":[61,129],"latter":[63],"stages":[64,132],"mitotic":[66,164],"prometaphase":[67],"before":[68],"complete":[70,98],"alignment":[71,99],"chromosomes":[73],"at":[74],"metaphase":[76],"plate.":[77],"some":[79],"cases,":[80],"such":[81],"cells":[82,92,124,144],"fail":[83],"divide":[85],"chromosomes,":[86],"resulting":[87,135],"polyploidy.":[89],"others,":[91],"proceed":[93],"anaphase":[95],"without":[96],"chromosomes.":[101],"These":[102],"phenotypes":[103],"can":[104,158],"be":[105],"explained":[106],"by":[107],"ability":[109],"overexpressed":[111],"inhibit":[115],"residual":[116],"anaphase-promoting":[117],"complex":[118],"(APC(Cdh1))":[119],"activity":[120],"persists":[122],"as":[123,143],"progress":[125],"up":[126],"early":[131],"mitosis,":[134],"abnormal":[138],"accumulation":[139,152],"APC(Cdh1)":[141],"substrates":[142],"enter":[145],"mitosis.":[146],"We":[147],"further":[148],"securin":[154],"B1":[157],"account":[159],"for":[160],"E-mediated":[163],"phenotype.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}