{"id":"https://openalex.org/W1982916195","doi":"https://doi.org/10.3109/03630268209083761","title":"The Screening of \u03b1- and \u03b2-Globin Chain Variants with Isoelectric Focusing","display_name":"The Screening of \u03b1- and \u03b2-Globin Chain Variants with Isoelectric Focusing","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W1982916195","doi":"https://doi.org/10.3109/03630268209083761","mag":"1982916195","pmid":"https://pubmed.ncbi.nlm.nih.gov/7174347"},"language":"en","primary_location":{"id":"doi:10.3109/03630268209083761","doi":"https://doi.org/10.3109/03630268209083761","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03630268209083761","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049287452","display_name":"Alain Francina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Francina","raw_affiliation_strings":["Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France","institution_ids":["https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080338882","display_name":"C. Baudonnet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Baudonnet","raw_affiliation_strings":["Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France","institution_ids":["https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065074215","display_name":"E Dorl\u00e9ac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Dorl\u00e9ac","raw_affiliation_strings":["Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France","institution_ids":["https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016689216","display_name":"F. Galact\u00e9ros","orcid":"https://orcid.org/0000-0003-2029-8126","observed_orcids":["https://orcid.org/0000-0003-2029-8126","https://orcid.org/0000-0001-8130-1208"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Galacteros","raw_affiliation_strings":["INSERM, U 91 - Ho\u00f4pital Henri Mondor, 94010, Creteil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U 91 - Ho\u00f4pital Henri Mondor, 94010, Creteil, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047145227","display_name":"Jean Delaunay","orcid":"https://orcid.org/0000-0002-6512-5483","observed_orcids":["https://orcid.org/0000-0002-6512-5483"]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Delaunay","raw_affiliation_strings":["Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biochimie B, Ho\u00f4pital Edouard Herriot - Place d'Arsonval, 6 9 374 Lyon, Cedex 2, France","institution_ids":["https://openalex.org/I4210123600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9822,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.76266016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"5","first_page":"481","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.921999990940094},{"id":"https://openalex.org/keywords/alpha-globin","display_name":"alpha-globin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/beta-globin","display_name":"beta-globin","score":1.0},{"id":"https://openalex.org/keywords/isoelectric-focusing","display_name":"isoelectric focusing","score":0.9819999933242798},{"id":"https://openalex.org/keywords/polyacrylamide-hydrogel","display_name":"polyacrylamide hydrogel","score":0.824999988079071},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.6510000228881836},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.7749999761581421},{"id":"https://openalex.org/keywords/charge-variation","display_name":"charge variation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mutation-detection","display_name":"mutation detection","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C50476208","wikidata":"https://www.wikidata.org/wiki/Q898861","display_name":"Isoelectric focusing","level":3,"score":0.9202787280082703},{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.8268897533416748},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.6530634164810181},{"id":"https://openalex.org/C2776920385","wikidata":"https://www.wikidata.org/wiki/Q17022368","display_name":"Hemoglobin variants","level":3,"score":0.6353358030319214},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5393028855323792},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.4698820412158966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44086793065071106},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4147108793258667},{"id":"https://openalex.org/C199185054","wikidata":"https://www.wikidata.org/wiki/Q552299","display_name":"Chain (unit)","level":2,"score":0.4100058674812317},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3765026926994324},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.33565276861190796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2476838231086731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1243746280670166},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08071231842041016},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007525","descriptor_name":"Isoelectric Focusing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3109/03630268209083761","doi":"https://doi.org/10.3109/03630268209083761","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03630268209083761","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},{"id":"pmid:7174347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7174347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1547680166","https://openalex.org/W1916564595","https://openalex.org/W1975034127","https://openalex.org/W1987590595","https://openalex.org/W2037830205","https://openalex.org/W2047034054","https://openalex.org/W2057432625","https://openalex.org/W2073984651"],"related_works":["https://openalex.org/W1916564595","https://openalex.org/W2081927643","https://openalex.org/W2005802445","https://openalex.org/W1964155376","https://openalex.org/W2141459466","https://openalex.org/W2005646727","https://openalex.org/W2334926478","https://openalex.org/W2085686391","https://openalex.org/W2055048115","https://openalex.org/W2062813494"],"abstract_inverted_index":{"A":[0,51],"simple":[1],"isoelectric":[2,66],"focusing":[3],"technique":[4],"is":[5,77],"presented":[6],"for":[7],"the":[8,20,38,49,57,61,64,69],"screening":[9],"of":[10,22,63,68,74],"alpha-":[11],"and":[12,60],"beta-globin":[13],"chain":[14],"variants":[15],"on":[16,37],"polyacrylamide":[17],"gel":[18],"in":[19],"presence":[21],"8":[23],"M":[24],"urea.":[25],"No":[26],"detergent":[27],"was":[28,54],"used.":[29],"Variants":[30],"focused":[31],"at":[32],"discrete":[33],"pH":[34],"values,":[35],"depending":[36],"charge":[39,58],"variation":[40,59],"(-2,":[41],"-1,":[42],"0,":[43],"+1":[44],"or":[45],"+2)":[46],"introduced":[47],"by":[48],"mutation.":[50],"linear":[52],"relationship":[53],"evidenced":[55],"between":[56],"shift":[62],"apparent":[65],"point":[67],"variants.":[70],"The":[71],"practical":[72],"interest":[73],"this":[75],"procedure":[76],"illustrated.":[78]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
