{"id":"https://openalex.org/W1982915733","doi":"https://doi.org/10.1115/sbc2012-80064","title":"Spatial and Temporal Control of Stem Cell Behavior in 3D Sequentially Crosslinked Macroporous Hydrogels","display_name":"Spatial and Temporal Control of Stem Cell Behavior in 3D Sequentially Crosslinked Macroporous Hydrogels","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W1982915733","doi":"https://doi.org/10.1115/sbc2012-80064","mag":"1982915733"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2012-80064","doi":"https://doi.org/10.1115/sbc2012-80064","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80064","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048322286","display_name":"Ross A. Marklein","orcid":"https://orcid.org/0000-0001-8045-0375","observed_orcids":["https://orcid.org/0000-0001-8045-0375"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ross A. Marklein","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026268740","display_name":"Jason A. Burdick","orcid":"https://orcid.org/0000-0002-2006-332X","observed_orcids":["https://orcid.org/0000-0002-2006-332X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Burdick","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0952381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"525","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.2240999937057495,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-mesenchymal-stem-cells","display_name":"human mesenchymal stem cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/macroporous-hydrogels","display_name":"macroporous hydrogels","score":0.9259999990463257},{"id":"https://openalex.org/keywords/matrix-mechanics","display_name":"matrix mechanics","score":0.6230000257492065},{"id":"https://openalex.org/keywords/tissue-stiffness","display_name":"tissue stiffness","score":0.8100000023841858},{"id":"https://openalex.org/keywords/post-myocardial-infarction","display_name":"post-myocardial infarction","score":0.8019999861717224},{"id":"https://openalex.org/keywords/heart-valve-calcification","display_name":"cardiac valve calcification","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ectopic-calcification","display_name":"ectopic calcification","score":0.9319999814033508},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6689873337745667},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6185353994369507},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.4424419403076172},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4414028227329254},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4347786009311676},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.4196704924106598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3787512183189392},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37401628494262695},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.3506617546081543},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32007575035095215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2914556860923767},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1556684374809265}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2012-80064","doi":"https://doi.org/10.1115/sbc2012-80064","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80064","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W93081371","https://openalex.org/W3048262645","https://openalex.org/W1970368333","https://openalex.org/W2386241483","https://openalex.org/W1986772674","https://openalex.org/W2770118279","https://openalex.org/W2807627867","https://openalex.org/W3016741759","https://openalex.org/W2625131095","https://openalex.org/W3212040808"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,17,32,48,102,145,148],"matrix":[3,41],"mechanics":[4,19,42,92,122,149],"on":[5,116,150],"stem":[6,62,130,151],"cell":[7,131,152],"behavior":[8],"has":[9,138],"received":[10],"considerable":[11],"attention":[12],"due":[13,72,89],"to":[14,29,73,77,79,90,121,135],"the":[15,30,146],"implications":[16],"tissue":[18,80],"as":[20,52,54,106,126,129],"not":[21,125],"only":[22],"a":[23,27,37,46],"consequence":[24],"but":[25],"also":[26],"contributor":[28],"development":[31],"certain":[33],"pathologies.":[34],"For":[35],"example,":[36],"significant":[38],"increase":[39],"in":[40,68,119,133,143],"(\u201ctissue":[43],"stiffening\u201d)":[44],"is":[45],"hallmark":[47],"post-myocardial":[49],"infarction":[50],"[1],":[51],"well":[53,112,127],"heart":[55],"valve":[56],"calcification":[57,108],"[2].":[58],"Recently,":[59],"human":[60],"mesenchymal":[61],"cells":[63],"(hMSCs)":[64],"have":[65,98],"been":[66,139],"implemented":[67],"post-infarct":[69],"therapeutic":[70],"strategies":[71],"their":[74],"potential":[75],"ability":[76],"contribute":[78],"healing":[81],"through":[82],"differentiation":[83,118,132],"and":[84,93],"trophic":[85,153],"factor":[86,154],"secretion.":[87],"However,":[88],"aberrant":[91],"other":[94],"microenvironment":[95],"cues,":[96],"studies":[97],"reported":[99],"deleterious":[100],"effects":[101],"hMSC":[103,117],"implantation,":[104],"such":[105],"ectopic":[107],"[3],":[109],"which":[110],"agrees":[111],"with":[113],"previous":[114],"reports":[115],"response":[120,134],"[4].":[123],"Although":[124],"documented":[128],"mechanics,":[136],"there":[137],"some":[140],"initial":[141],"evidence":[142],"support":[144],"influence":[147],"secretion":[155],"[5].":[156]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2025-10-10T00:00:00"}
