{"id":"https://openalex.org/W1982911303","doi":"https://doi.org/10.1186/1479-5876-10-s2-a14","title":"Understanding hepatotoxicity \u2013 from patients to mice to computer","display_name":"Understanding hepatotoxicity \u2013 from patients to mice to computer","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W1982911303","doi":"https://doi.org/10.1186/1479-5876-10-s2-a14","mag":"1982911303"},"language":"en","primary_location":{"id":"doi:10.1186/1479-5876-10-s2-a14","doi":"https://doi.org/10.1186/1479-5876-10-s2-a14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-10-s2-a14","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A14","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062878299","display_name":"Paul Brent Watkins","orcid":"https://orcid.org/0000-0001-9541-8917","observed_orcids":["https://orcid.org/0000-0001-9541-8917","https://orcid.org/0009-0008-3343-4418"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul B Watkins","raw_affiliation_strings":["Department of Medicine and Pharmacy University of North Carolina, Chapel Hill, NC, USA","Department of Medicine and Pharmacy University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Pharmacy University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Medicine and Pharmacy University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062878299"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15902732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"S2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9850000143051147},{"id":"https://openalex.org/keywords/idiosyncratic-hepatotoxicity","display_name":"idiosyncratic hepatotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/preclinical-safety-evaluation","display_name":"preclinical safety","score":0.6159999966621399},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.671999990940094},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.4490000009536743},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.7580000162124634},{"id":"https://openalex.org/keywords/inbred-mouse-models","display_name":"inbred mouse models","score":0.6430000066757202},{"id":"https://openalex.org/keywords/ximelagatran","display_name":"ximelagatran","score":0.7549999952316284},{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4658530354499817},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35625550150871277},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34432998299598694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23902621865272522}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1479-5876-10-s2-a14","doi":"https://doi.org/10.1186/1479-5876-10-s2-a14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-10-s2-a14","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A14","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3479849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3479849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a5cb158ac3444770aef58165b1c4e7bf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a5cb158ac3444770aef58165b1c4e7bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 10, Iss Suppl 2, p A14 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1479-5876-10-s2-a14","doi":"https://doi.org/10.1186/1479-5876-10-s2-a14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-10-s2-a14","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-10-S2-A14","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982911303.pdf","grobid_xml":"https://content.openalex.org/works/W1982911303.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W2048182022"],"abstract_inverted_index":{"Drug":[0,334],"Induced":[1],"Liver":[2,167],"Injury":[3,168],"(DILI)":[4],"remains":[5],"the":[6,33,57,86,95,138,143,150,161,164,172,220,235,296,312,317,331],"major":[7],"adverse":[8],"drug":[9,101,324],"event":[10],"that":[11,38,45,69,79,142,177,286,304],"leads":[12],"to":[13,24,56,107,146,192,202,241,274,281,310],"termination":[14],"of":[15,36,51,98,137,163,175,222,246,262,271,319],"clinical":[16],"development":[17],"programs":[18],"and":[19,30,182,227,280,284,330,333],"regulatory":[20],"actions":[21],"including":[22,248],"failure":[23],"approve":[25],"for":[26,85,117,238,251,257],"marketing,":[27],"restricted":[28],"indications,":[29],"withdrawal":[31],"from":[32,103,185,208,254],"marketplace.The":[34],"type":[35],"DILI":[37,96,148,289,321],"is":[39,42,134,178,300,305],"most":[40],"problematic":[41],"\"idiosyncratic\"":[43],"meaning":[44],"only":[46],"a":[47,100,113,244,263,301,307],"very":[48],"small":[49],"fraction":[50],"treated":[52,256],"patients":[53,186,255],"are":[54,80,149,158,196,231,268],"susceptible":[55],"DILI.Current":[58],"preclinical":[59,90,125],"models,":[60],"even":[61,120],"\"humanized\"":[62],"ones,":[63],"do":[64],"not":[65,93,129],"reliably":[66],"identify":[67,282],"molecules":[68],"have":[70,153,188,214,294],"this":[71],"liability":[72,322],"and,":[73],"conversely":[74],"predict":[75,112],"liabilities":[76],"in":[77,81,211,291,323],"molecule":[78],"fact":[82],"quite":[83],"safe":[84],"liver.For":[87],"example,":[88],"current":[89],"testing":[91,126],"does":[92],"detect":[94],"potential":[97],"xymelagatran,":[99],"withdrawn":[102],"worldwide":[104],"markets":[105],"due":[106],"idiosyncratic":[108],"hepatotoxicity":[109],"but":[110],"would":[111],"high":[114],"liver":[115,225],"risk":[116],"acetaminophen":[118],"(paracetamol)":[119],"when":[121],"taken":[122],"as":[123,260],"directed.Reliable":[124],"will":[127],"probably":[128],"be":[130],"developed":[131],"until":[132],"there":[133],"greater":[135],"understanding":[136],"mechanisms":[139],"underlying":[140],"DILI.Reasoning":[141],"best":[144],"models":[145],"study":[147],"people":[151],"who":[152,187],"actually":[154],"experienced":[155,189],"it,":[156],"we":[157,195,213,293],"capitalizing":[159],"on":[160],"resources":[162],"US":[165],"Drug-Induced":[166],"Network":[169],"(DILIN-supported":[170],"by":[171],"National":[173],"Institutes":[174],"Health)":[176],"collecting":[179],"genomic":[180],"DNA":[181,217],"other":[183],"biospecimens":[184],"DILI.In":[190],"addition":[191],"genetic":[193,278],"studies,":[194],"partnering":[197,233],"with":[198,219,234,316],"Cellular":[199],"Dynamics":[200],"International":[201],"reprogram":[203],"induced":[204],"pleuripotent":[205],"stem":[206],"cells":[207],"DILIN":[209],"subjects":[210],"whom":[212],"complete":[215],"exomic":[216],"sequence":[218],"goal":[221,318],"producing":[223],"patientspecific":[224],"cultures,":[226],"ultimately,":[228],"humanized":[229],"mice.We":[230],"also":[232],"Shanghai":[236],"Centers":[237],"Disease":[239],"Control":[240],"prospectively":[242],"collect":[243],"variety":[245],"biospecimens,":[247],"whole":[249],"blood":[250],"transcriptome":[252],"analysis,":[253],"active":[258],"tuberculosis":[259],"part":[261],"larger":[264],"biomarker":[265],"discovery":[266],"initiative.We":[267],"using":[269],"panels":[270],"inbred":[272],"mice":[273],"mimic":[275],"patient":[276],"population":[277],"diversity":[279],"genes":[283],"pathways":[285],"may":[287],"underlie":[288],"susceptibility":[290],"patients.Finally,":[292],"established":[295],"DILIsim":[297],"Initiative":[298],"which":[299],"public-private":[302],"partnership":[303],"building":[306],"computer":[308],"model":[309],"synthesize":[311],"rapidly":[313],"accumulating":[314],"data":[315],"predicting":[320],"candidates.DILIsim":[325],"involves":[326],"10":[327],"pharmaceutical":[328],"companies":[329],"Food":[332],"Administration.":[335]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}