{"id":"https://openalex.org/W1982901074","doi":"https://doi.org/10.1111/j.1600-0773.1985.tb00043.x","title":"Lack of Hepatotoxicity after Long\u2013term Administration of Cyanamide in Rats: A Histological and Biochemical Study","display_name":"Lack of Hepatotoxicity after Long\u2013term Administration of Cyanamide in Rats: A Histological and Biochemical Study","publication_year":1985,"publication_date":"1985-10-01","ids":{"openalex":"https://openalex.org/W1982901074","doi":"https://doi.org/10.1111/j.1600-0773.1985.tb00043.x","mag":"1982901074","pmid":"https://pubmed.ncbi.nlm.nih.gov/4083036"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0773.1985.tb00043.x","doi":"https://doi.org/10.1111/j.1600-0773.1985.tb00043.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1985.tb00043.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210230610","display_name":"Acta Pharmacologica et Toxicologica","issn_l":"0001-6683","issn":["0001-6683"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica et Toxicologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112173316","display_name":"Rosendo Obach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Obach","raw_affiliation_strings":["Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]},{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001169371","display_name":"Antonio Rives","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Rives","raw_affiliation_strings":["The Department of Pathology of the School of Medicine, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology of the School of Medicine, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. M. Vall\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. M. Vall\u00e9s","raw_affiliation_strings":["Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]},{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027094683","display_name":"\u00c0ngel Menargues","orcid":"https://orcid.org/0000-0003-4800-9867","observed_orcids":["https://orcid.org/0000-0003-4800-9867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Menargues","raw_affiliation_strings":["Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]},{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072621630","display_name":"Juan Pru\u00f1onosa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Pru\u00f1onosa","raw_affiliation_strings":["Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]},{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"J. Vall\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Vall\u00e9s","raw_affiliation_strings":["Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Miro\u0301, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]},{"raw_affiliation_string":"Research Department of S. A. Lasa Laboratories, c/. Laurea Mir\u00f3, 385, Sant Feliu de Llobregat, Barcelona","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8166,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.67964137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"4","first_page":"279","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12305","display_name":"Cassava research and cyanide","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanamide","display_name":"cyanamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-toxicity","display_name":"chronic toxicity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.9110000133514404},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.7369999885559082},{"id":"https://openalex.org/keywords/inclusion-bodies","display_name":"inclusion bodies","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6990000009536743},{"id":"https://openalex.org/keywords/intraperitoneal-administration","display_name":"intraperitoneal administration","score":0.968999981880188},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2779606280","wikidata":"https://www.wikidata.org/wiki/Q414555","display_name":"Cyanamide","level":2,"score":0.9764211177825928},{"id":"https://openalex.org/C2994203108","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Hepatic function","level":2,"score":0.5330141186714172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4765109121799469},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.476365327835083},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4432612657546997},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4253005385398865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39786872267723083},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3609618842601776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24683624505996704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13285675644874573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003484","descriptor_name":"Cyanamide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007441","descriptor_name":"Intubation, Gastrointestinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0773.1985.tb00043.x","doi":"https://doi.org/10.1111/j.1600-0773.1985.tb00043.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1985.tb00043.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210230610","display_name":"Acta Pharmacologica et Toxicologica","issn_l":"0001-6683","issn":["0001-6683"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica et Toxicologica","raw_type":"journal-article"},{"id":"pmid:4083036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4083036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica et toxicologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2005425186","https://openalex.org/W2027646938","https://openalex.org/W2045076768","https://openalex.org/W2057320950","https://openalex.org/W2058282997","https://openalex.org/W2092019514","https://openalex.org/W2130239689","https://openalex.org/W2400137823","https://openalex.org/W2401446895","https://openalex.org/W2915909979","https://openalex.org/W2942103126","https://openalex.org/W4298134920"],"related_works":["https://openalex.org/W2462995766","https://openalex.org/W3146000023","https://openalex.org/W2401446895","https://openalex.org/W184714284","https://openalex.org/W2407081723","https://openalex.org/W2061447499","https://openalex.org/W2046724731","https://openalex.org/W2058282997","https://openalex.org/W2901615934","https://openalex.org/W7100449180"],"abstract_inverted_index":{"An":[0],"experimental":[1],"long-term":[2],"hepatotoxicity":[3],"study":[4],"of":[5,21,43,75],"cyanamide":[6,22,60],"in":[7,34,58,81],"Sprague-Dawley":[8],"and":[9,24,45],"Wistar":[10],"rats":[11],"has":[12,48],"been":[13,32,64],"carried":[14],"out.":[15],"After":[16],"six":[17],"months":[18],"oral":[19],"administration":[20,42],"(2.7":[23],"25":[25],"mg/kg/day)":[26],"no":[27,55,72],"significant":[28,73],"histological":[29],"changes":[30],"have":[31,63,70],"observed":[33],"the":[35],"liver.":[36],"Similarly,":[37],"a":[38],"one":[39],"year":[40],"intraperitoneal":[41],"8":[44],"16":[46],"mg/kg/day":[47],"not":[49],"induced":[50],"any":[51,59],"hepatic":[52,67,76],"change.":[53],"Specifically,":[54],"inclusion":[56],"bodies":[57],"treated":[61],"rat":[62],"detected.":[65],"Moreover,":[66],"biochemical":[68],"parameters":[69],"shown":[71],"impairment":[74],"function":[77],"at":[78],"doses":[79],"used":[80],"human":[82],"therapy":[83],"(0.5-1":[84],"mg/kg).":[85]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
