{"id":"https://openalex.org/W1982876996","doi":"https://doi.org/10.1016/0014-5793(91)80248-2","title":"An upward shift of intracellular pH rather than the final absolute pH value is critical for controlling gap junction permeability in tumor promoter\u2010treated cells","display_name":"An upward shift of intracellular pH rather than the final absolute pH value is critical for controlling gap junction permeability in tumor promoter\u2010treated cells","publication_year":1991,"publication_date":"1991-02-11","ids":{"openalex":"https://openalex.org/W1982876996","doi":"https://doi.org/10.1016/0014-5793(91)80248-2","mag":"1982876996","pmid":"https://pubmed.ncbi.nlm.nih.gov/1995342"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(91)80248-2","doi":"https://doi.org/10.1016/0014-5793(91)80248-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(91)80248-2","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2891%2980248-2","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2891%2980248-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027599075","display_name":"Irina V. Budunova","orcid":"https://orcid.org/0000-0001-5880-6822","observed_orcids":["https://orcid.org/0000-0001-5880-6822"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina Budunova","raw_affiliation_strings":["A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR","All-Union Oncological Center of the USSR, Moscow, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"All-Union Oncological Center of the USSR, Moscow, USSR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031685590","display_name":"Leonid A. Mittelman","orcid":"https://orcid.org/0009-0001-3461-7370","observed_orcids":["https://orcid.org/0009-0001-3461-7370"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Leonid A. Mittelman","raw_affiliation_strings":["A.N. Belozersky Laboratory of Molekular Biology and Bioorganic Chemistry, Moscow State University, Moscow 119899, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.N. Belozersky Laboratory of Molekular Biology and Bioorganic Chemistry, Moscow State University, Moscow 119899, USSR","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053982479","display_name":"Leonid B Margolis","orcid":"https://orcid.org/0000-0002-1960-1928","observed_orcids":["https://orcid.org/0000-0002-1960-1928"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Leonid B. Margolis","raw_affiliation_strings":["A.N. Belozersky Laboratory of Molekular Biology and Bioorganic Chemistry, Moscow State University, Moscow 119899, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.N. Belozersky Laboratory of Molekular Biology and Bioorganic Chemistry, Moscow State University, Moscow 119899, USSR","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I19880235"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.6607,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64766144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"279","issue":"1","first_page":"52","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ph-change","display_name":"pH change","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gap-junction-permeability","display_name":"gap junction permeability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-promoters","display_name":"tumor promoters","score":0.9139999747276306},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hamster-fibroblasts","display_name":"hamster fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.5320000052452087},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7218844890594482},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.719184160232544},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.7140253186225891},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.6585630774497986},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.542686939239502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5350533723831177},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.5252401828765869},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.501854658126831},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24392816424369812},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2369382381439209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21562302112579346},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.09330001473426819}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(91)80248-2","doi":"https://doi.org/10.1016/0014-5793(91)80248-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(91)80248-2","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2891%2980248-2","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:1995342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1995342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(91)80248-2","doi":"https://doi.org/10.1016/0014-5793(91)80248-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(91)80248-2","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2891%2980248-2","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982876996.pdf","grobid_xml":"https://content.openalex.org/works/W1982876996.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1790873293","https://openalex.org/W1979552596","https://openalex.org/W1982923513","https://openalex.org/W1992261492","https://openalex.org/W1993282564","https://openalex.org/W2033936610","https://openalex.org/W2045709891","https://openalex.org/W2048603114","https://openalex.org/W2055608251","https://openalex.org/W2070398576","https://openalex.org/W2091319839","https://openalex.org/W2098335741","https://openalex.org/W2103526148","https://openalex.org/W2123929920","https://openalex.org/W2149671085","https://openalex.org/W2266399022","https://openalex.org/W4235472948"],"related_works":["https://openalex.org/W2080135307","https://openalex.org/W2103526148","https://openalex.org/W2057246157","https://openalex.org/W2036980165","https://openalex.org/W223359613","https://openalex.org/W2318276392","https://openalex.org/W1969243022","https://openalex.org/W2108170421","https://openalex.org/W7072090891","https://openalex.org/W2013924784"],"abstract_inverted_index":{"The":[0],"tumor":[1],"promoter":[2],"TPA":[3,38],"is":[4,19,49,62],"found":[5],"to":[6],"inhibit":[7],"gap":[8,45,68],"junction":[9,46,69],"permeability":[10,70],"in":[11,24,34,71],"monolayer":[12],"cultures":[13],"of":[14,53,67,74],"hamster":[15],"fibroblasts.":[16],"This":[17],"effect":[18],"associated":[20],"with":[21],"an":[22,32],"increase":[23,33],"intracellular":[25],"pH.":[26],"Here":[27],"we":[28],"show":[29],"that":[30,61],"neither":[31],"pHi":[35,54],"alone":[36],"nor":[37],"treatment":[39],"under":[40],"conditions":[41],"preventing":[42],"pHi-shift":[43,59],"affect":[44],"permeability.":[47],"It":[48],"not":[50],"the":[51,58,65,72],"level":[52],"reached,":[55],"but":[56],"rather":[57],"itself":[60],"essential":[63],"for":[64],"inhibition":[66],"presence":[73],"TPA.":[75]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
