{"id":"https://openalex.org/W1982589840","doi":"https://doi.org/10.1016/s0006-3495(98)77709-4","title":"Role of Hydrophobicity and Solvent-Mediated Charge-Charge Interactions in Stabilizing \u03b1-Helices","display_name":"Role of Hydrophobicity and Solvent-Mediated Charge-Charge Interactions in Stabilizing \u03b1-Helices","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1982589840","doi":"https://doi.org/10.1016/s0006-3495(98)77709-4","mag":"1982589840","pmid":"https://pubmed.ncbi.nlm.nih.gov/9826588","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1299939"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-3495(98)77709-4","doi":"https://doi.org/10.1016/s0006-3495(98)77709-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(98)77709-4","pdf_url":"http://www.cell.com/article/S0006349598777094/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S0006349598777094/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087430326","display_name":"Jorge A. Vila","orcid":"https://orcid.org/0000-0001-7557-9350","observed_orcids":["https://orcid.org/0000-0001-7557-9350"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR","US"],"is_corresponding":false,"raw_author_name":"Jorge A. Vila","raw_affiliation_strings":["Universidad Nacional de San Luis, Facultad de Ciencias F\u00edsico Matem\u00e1ticas y Naturales, and Instituto de Matem\u00e1tica Aplicada San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, 5700 San Luis, Argentina","Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de San Luis, Facultad de Ciencias F\u00edsico Matem\u00e1ticas y Naturales, and Instituto de Matem\u00e1tica Aplicada San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]},{"raw_affiliation_string":"Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089592476","display_name":"Daniel R. Ripoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Ripoll","raw_affiliation_strings":["Cornell Theory Center, Cornell University, Ithaca, New York 14853 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell Theory Center, Cornell University, Ithaca, New York 14853 USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101956247","display_name":"Myriam Villegas","orcid":"https://orcid.org/0000-0002-3663-9012","observed_orcids":["https://orcid.org/0000-0002-3663-9012"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I73822459","display_name":"National University of San Luis","ror":"https://ror.org/00mczdx43","country_code":"AR","type":"education","lineage":["https://openalex.org/I73822459"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Myriam E. Villegas","raw_affiliation_strings":["Universidad Nacional de San Luis, Facultad de Ciencias F\u00edsico Matem\u00e1ticas y Naturales, and Instituto de Matem\u00e1tica Aplicada San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, 5700 San Luis, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional de San Luis, Facultad de Ciencias F\u00edsico Matem\u00e1ticas y Naturales, and Instituto de Matem\u00e1tica Aplicada San Luis, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, 5700 San Luis, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I73822459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110195908","display_name":"Yury N. Vorobjev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yury N. Vorobjev","raw_affiliation_strings":["Department of Biochemistry, FLOB, The University of North Carolina, Chapel Hill, North Carolina 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, FLOB, The University of North Carolina, Chapel Hill, North Carolina 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111806209","display_name":"Harold A. Scheraga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harold A. Scheraga","raw_affiliation_strings":["Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111806209"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.969,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.71821174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"75","issue":"6","first_page":"2637","last_page":"2646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-helix-stabilization","display_name":"alpha-helix stabilization","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.8230000138282776},{"id":"https://openalex.org/keywords/charge-charge-interactions","display_name":"charge-charge interactions","score":0.9409999847412109},{"id":"https://openalex.org/keywords/solvent-mediated-interactions","display_name":"solvent-mediated interactions","score":0.7490000128746033},{"id":"https://openalex.org/keywords/solvation-free-energy","display_name":"solvation free energy","score":0.902999997138977},{"id":"https://openalex.org/keywords/pk-shift","display_name":"pK shift","score":0.6460000276565552},{"id":"https://openalex.org/keywords/conformational-preferences","display_name":"conformational preferences","score":0.6079999804496765},{"id":"https://openalex.org/keywords/solvent-polarization","display_name":"solvent polarization","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7266510725021362},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.707946240901947},{"id":"https://openalex.org/C148093993","wikidata":"https://www.wikidata.org/wiki/Q739398","display_name":"Solvation","level":3,"score":0.6678260564804077},{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.6676832437515259},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5390874743461609},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5363273620605469},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.45286813378334045},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.4448447823524475},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.42430996894836426},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.41589170694351196},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.41527092456817627},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4130169749259949},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.39006462693214417},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.30678439140319824},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.27608418464660645},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1002328097820282},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.09945932030677795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08870857954025269},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004563","descriptor_name":"Electrochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/s0006-3495(98)77709-4","doi":"https://doi.org/10.1016/s0006-3495(98)77709-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(98)77709-4","pdf_url":"http://www.cell.com/article/S0006349598777094/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1299939","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1299939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:9826588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9826588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:n296x5342","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/zksz-1y61","pdf_url":"https://doi.org/10.17615/zksz-1y61","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biophysical Journal, 75(6)","raw_type":"Article"},{"id":"doi:10.17615/zksz-1y61","doi":"https://doi.org/10.17615/zksz-1y61","is_oa":true,"landing_page_url":"https://doi.org/10.17615/zksz-1y61","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/s0006-3495(98)77709-4","doi":"https://doi.org/10.1016/s0006-3495(98)77709-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0006-3495(98)77709-4","pdf_url":"http://www.cell.com/article/S0006349598777094/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G110759567","display_name":null,"funder_award_id":"1 RO3 TW00857-01","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G116824722","display_name":"CONFORMATIONAL COUPLING WITH PH IN POLYPEPTIDES","funder_award_id":"R03TW000857","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G721822166","display_name":null,"funder_award_id":"GM--14312","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7429297341","display_name":"Theoretical Studies of Protein Folding","funder_award_id":"9513167","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000158662","display_name":null,"funder_award_id":"GM\u201014312","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306777","display_name":"National Foundation for Cancer Research","ror":"https://ror.org/04v83ky93"},{"id":"https://openalex.org/F4320311362","display_name":"Universidad Nacional de San Luis","ror":"https://ror.org/00mczdx43"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982589840.pdf","grobid_xml":"https://content.openalex.org/works/W1982589840.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W176261813","https://openalex.org/W313299630","https://openalex.org/W1491642680","https://openalex.org/W1554521867","https://openalex.org/W1565826566","https://openalex.org/W1577870180","https://openalex.org/W1633014878","https://openalex.org/W1831346701","https://openalex.org/W1964315420","https://openalex.org/W1966041739","https://openalex.org/W1968673134","https://openalex.org/W1969033782","https://openalex.org/W1969847482","https://openalex.org/W1972772174","https://openalex.org/W1974427517","https://openalex.org/W1974778989","https://openalex.org/W1977308661","https://openalex.org/W1985522914","https://openalex.org/W1990719397","https://openalex.org/W1993273221","https://openalex.org/W1995938191","https://openalex.org/W1997240546","https://openalex.org/W2000224406","https://openalex.org/W2001130582","https://openalex.org/W2003697928","https://openalex.org/W2004455414","https://openalex.org/W2013317256","https://openalex.org/W2014355769","https://openalex.org/W2015137784","https://openalex.org/W2019244818","https://openalex.org/W2022038256","https://openalex.org/W2022469662","https://openalex.org/W2025461277","https://openalex.org/W2030935884","https://openalex.org/W2036305809","https://openalex.org/W2037631365","https://openalex.org/W2053797131","https://openalex.org/W2054483713","https://openalex.org/W2056760934","https://openalex.org/W2056770911","https://openalex.org/W2057553906","https://openalex.org/W2058152641","https://openalex.org/W2060354883","https://openalex.org/W2062081085","https://openalex.org/W2063831812","https://openalex.org/W2064731770","https://openalex.org/W2073745636","https://openalex.org/W2075369230","https://openalex.org/W2079589162","https://openalex.org/W2083863413","https://openalex.org/W2086204890","https://openalex.org/W2094604448","https://openalex.org/W2094695671","https://openalex.org/W2108508060","https://openalex.org/W2111554878","https://openalex.org/W2114722917","https://openalex.org/W2119544526","https://openalex.org/W2126912623","https://openalex.org/W2141268408","https://openalex.org/W2162504629","https://openalex.org/W2165145735","https://openalex.org/W2165996087","https://openalex.org/W2324480504","https://openalex.org/W2330066175","https://openalex.org/W2334211226","https://openalex.org/W2949250147","https://openalex.org/W2954299585","https://openalex.org/W2997715027","https://openalex.org/W4237031200","https://openalex.org/W4241691260","https://openalex.org/W4242921232","https://openalex.org/W4243207996","https://openalex.org/W4250709082","https://openalex.org/W4250709836"],"related_works":["https://openalex.org/W2067046336","https://openalex.org/W2057553906","https://openalex.org/W2074101186","https://openalex.org/W2560689812","https://openalex.org/W2022469662","https://openalex.org/W4294577282","https://openalex.org/W2162673649","https://openalex.org/W4239851005","https://openalex.org/W2051139331","https://openalex.org/W2064516585"],"abstract_inverted_index":{"A":[0],"theoretical":[1],"study":[2,235],"to":[3,219,242],"identify":[4],"the":[5,25,40,43,46,49,143,151,164,168,178,193,206,211,220,244,247],"conformational":[6],"preferences":[7],"of":[8,22,24,45,93,101,124,139,150,163,167,181,203,205,233,246],"lysine-based":[9,96],"oligopeptides":[10,26],"has":[11,59],"been":[12,28,60,128],"carried":[13],"out.":[14],"The":[15,147,231],"solvation":[16],"free":[17,20],"energy":[18,21],"and":[19,48,66,111,132,254],"ionization":[23,50],"have":[27,69,127],"calculated":[29],"by":[30,224],"using":[31],"a":[32,54,237],"fast":[33],"multigrid":[34],"boundary":[35],"element":[36],"method":[37],"that":[38,63,81,258],"considers":[39],"coupling":[41],"between":[42,116],"conformation":[44,149],"molecule":[47],"equilibria":[51],"explicitly,":[52],"at":[53,90],"given":[55],"pH":[56,94],"value.":[57],"It":[58],"found":[61],"experimentally":[62,136],"isolated":[64],"alanine":[65],"lysine":[67,104,131,169,189],"residues":[68,134],"somewhat":[70],"small":[71],"intrinsic":[72],"helix-forming":[73],"tendencies;":[74],"however,":[75],"results":[76,232],"from":[77,142,154],"these":[78,155],"simulations":[79,156],"indicate":[80],"conformations":[82,180,200],"containing":[83],"right-handed":[84,260],"alpha-helical":[85,199,261],"turns":[86],"are":[87,120,174],"energetically":[88],"favorable":[89],"low":[91],"values":[92],"for":[95,130,161],"oligopeptides.":[97],"Also,":[98],"unusual":[99],"patterns":[100],"interactions":[102,202],"among":[103],"side":[105,208],"chains":[106,209],"with":[107,184,201,210,240],"large":[108,158,172],"hydrophobic":[109],"contacts":[110],"close":[112],"proximity":[113],"(5-6":[114],"A)":[115],"charged":[117,125],"NH3+":[118,165],"groups":[119,126,166],"observed.":[121],"Similar":[122],"arrangements":[123],"seen":[129],"arginine":[133],"in":[135,177,214],"determined":[137],"structures":[138],"proteins":[140],"available":[141],"Protein":[144],"Data":[145],"Bank.":[146],"lowest-free-energy":[148],"sequence":[152,194],"Ac-(LYS)6-NMe":[153],"showed":[157],"pKalpha":[159],"shifts":[160],"some":[162],"residues.":[170,190],"Such":[171],"effects":[173],"not":[175],"observed":[176],"lowest-energy":[179],"oligopeptide":[182],"sequences":[183],"two,":[185],"three,":[186],"or":[187],"four":[188],"Calculations":[191],"on":[192],"Ac-LYS-(ALA)4-LYS-NMe":[195],"also":[196],"reveal":[197],"low-energy":[198],"one":[204,221],"LYS":[207],"helix":[212],"backbone":[213],"an":[215],"arrangement":[216],"quite":[217],"similar":[218],"described":[222],"recently":[223],"(Proc.":[225],"Natl.":[226],"Acad.":[227],"Sci.":[228],"U.S.A.":[229],"93:4025-4029).":[230],"this":[234],"provide":[236],"sound":[238],"basis":[239],"which":[241],"discuss":[243],"nature":[245],"interactions,":[248],"such":[249],"as":[250],"hydrophobicity,":[251],"charge-charge":[252],"interaction,":[253],"solvent":[255],"polarization":[256],"effects,":[257],"stabilize":[259],"conformations.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
